NCT00005359

Brief Summary

To investigate the genetics of asthma by reexamining a carefully characterized population of patients with asthma, and by studying their families.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jul 1994

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 1994

Completed
5.9 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
7.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2008

Completed
Last Updated

July 12, 2016

Status Verified

July 1, 2008

Enrollment Period

13.8 years

First QC Date

May 25, 2000

Last Update Submit

July 11, 2016

Conditions

AsthmaLung Diseases

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (30)

  • Bleecker ER, Postma DS, Meyers DA. Genetic susceptibility to asthma in a changing environment. Ciba Found Symp. 1997;206:90-9; discussion 99-105, 106-10. doi: 10.1002/9780470515334.ch6.

    PMID: 9257007BACKGROUND

  • Levitt RC, Holroyd KJ. Fine-structure mapping of genes providing susceptibility to asthma on chromosome 5q31-q33. Clin Exp Allergy. 1995 Nov;25 Suppl 2:119-23. doi: 10.1111/j.1365-2222.1995.tb00439.x. No abstract available.

    PMID: 8590330BACKGROUND

  • Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995 Oct 5;333(14):894-900. doi: 10.1056/NEJM199510053331402.

    PMID: 7666875BACKGROUND

  • DiSilvestre D, Kleeberger SR, Johns J, Levitt RC. Structure and DNA sequence of the mouse MnSOD gene. Mamm Genome. 1995 Apr;6(4):281-4. doi: 10.1007/BF00352417.

    PMID: 7613035BACKGROUND

  • Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995 Apr 10;26(3):637-8. doi: 10.1016/0888-7543(95)80194-q. No abstract available.

    PMID: 7607699BACKGROUND

  • Meyers DA, Bleecker ER. Approaches to mapping genes for allergy and asthma. Am J Respir Crit Care Med. 1995 Jul;152(1):411-3. doi: 10.1164/ajrccm.152.1.7599858. No abstract available.

    PMID: 7599858BACKGROUND

  • Levitt RC, Ewart SL. Genetic susceptibility to atracurium-induced bronchoconstriction. Am J Respir Crit Care Med. 1995 May;151(5):1537-42. doi: 10.1164/ajrccm.151.5.7735612.

    PMID: 7735612BACKGROUND

  • Levitt RC, Kiser MB, Dragwa C, Jedlicka AE, Xu J, Meyers DA, Hudson JR. Fluorescence-based resource for semiautomated genomic analyses using microsatellite markers. Genomics. 1994 Nov 15;24(2):361-5. doi: 10.1006/geno.1994.1628.

    PMID: 7698760BACKGROUND

  • Schwengel DA, Jedlicka AE, Nanthakumar EJ, Weber JL, Levitt RC. Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques. Genomics. 1994 Jul 1;22(1):46-54. doi: 10.1006/geno.1994.1344.

    PMID: 7959791BACKGROUND

  • He P, Ma Y, Zhao G, Dai H, Li H, Chang L, Zhang Z. FaRE1: a transcriptionally active Ty1-copia retrotransposon in strawberry. J Plant Res. 2010 Sep;123(5):707-14. doi: 10.1007/s10265-009-0290-0. Epub 2009 Dec 18.

    PMID: 20020171BACKGROUND

  • Howard TD, Bleecker ER, Stine OC. Fluorescent allele-specific PCR (FAS-PCR) improves the reliability of single nucleotide polymorphism screening. Biotechniques. 1999 Mar;26(3):380-1. doi: 10.2144/99263bm01. No abstract available.

    PMID: 10090967BACKGROUND

  • Stine OC, Xu J, Meyers DA, Bleecker ER. Approaches to fine mapping in asthma. Clin Exp Allergy. 1998 Apr;28 Suppl 1:98-100; discussion 108-10. doi: 10.1046/j.1365-2222.1998.0280s1098.x. No abstract available.

    PMID: 9641604BACKGROUND

  • Panhuysen CI, Bleecker ER, Koeter GH, Meyers DA, Postma DS. Characterization of obstructive airway disease in family members of probands with asthma. An algorithm for the diagnosis of asthma. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1734-42. doi: 10.1164/ajrccm.157.6.9606088.

    PMID: 9620899BACKGROUND

  • Bleecker ER, Postma DS, Meyers DA. Evidence for multiple genetic susceptibility loci for asthma. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S113-6. doi: 10.1164/ajrccm.156.4.12tac7.

    PMID: 9351590BACKGROUND

  • Bleecker ER, Amelung PJ, Levitt RC, Postma DS, Meyers DA. Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin Exp Allergy. 1995 Nov;25 Suppl 2:84-8; discussion 95-6. doi: 10.1111/j.1365-2222.1995.tb00430.x. No abstract available.

    PMID: 8590353BACKGROUND

  • Meyers DA, Xu J, Postma DS, Levitt RC, Bleecker ER. Two locus segregation and linkage analysis for total serum IgE levels. Clin Exp Allergy. 1995 Nov;25 Suppl 2:113-5. doi: 10.1111/j.1365-2222.1995.tb00437.x. No abstract available.

    PMID: 8590328BACKGROUND

  • Wiesch DG, Meyers DA. Strategies for analyzing genotype-phenotype relationships in asthma. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S482-6. doi: 10.1016/s0091-6749(00)90047-2.

    PMID: 10669528BACKGROUND

  • Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for asthma and allergy. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S477-81. doi: 10.1016/s0091-6749(00)90046-0.

    PMID: 10669527BACKGROUND

  • Koppelman GH, Reijmerink NE, Colin Stine O, Howard TD, Whittaker PA, Meyers DA, Postma DS, Bleecker ER. Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med. 2001 Mar;163(4):965-9. doi: 10.1164/ajrccm.163.4.2004164.

    PMID: 11282774BACKGROUND

  • Xu J, Postma DS, Howard TD, Koppelman GH, Zheng SL, Stine OC, Bleecker ER, Meyers DA. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet. 2000 Nov;67(5):1163-73. doi: 10.1086/321190. Epub 2000 Oct 6.

    PMID: 11023809BACKGROUND

  • Koppelman GH, Stine OC, Xu J, Howard TD, Zheng SL, Kauffman HF, Bleecker ER, Meyers DA, Postma DS. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol. 2002 Mar;109(3):498-506. doi: 10.1067/mai.2002.122235.

    PMID: 11897998BACKGROUND

  • Xu J, Bleecker ER, Jongepier H, Howard TD, Koppelman GH, Postma DS, Meyers DA. Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. Am J Hum Genet. 2002 Sep;71(3):646-50. doi: 10.1086/342216. Epub 2002 Jul 15.

    PMID: 12119602BACKGROUND

  • Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for allergic diseases. Chest. 2003 Mar;123(3 Suppl):363S-8S. doi: 10.1378/chest.123.3_suppl.363s-a.

    PMID: 12628976BACKGROUND

  • Koppelman GH, Jansen DF, Schouten JP, van der Heide S, Bleecker ER, Meyers DA, Postma DS. Sibling effect on atopy in children of patients with asthma. Clin Exp Allergy. 2003 Feb;33(2):170-5. doi: 10.1046/j.1365-2222.2003.01591.x.

    PMID: 12580908BACKGROUND

  • Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol. 2003 Oct;112(4):717-22. doi: 10.1016/s0091-6749(03)01939-0.

    PMID: 14564349BACKGROUND

  • Jongepier H, Boezen HM, Dijkstra A, Howard TD, Vonk JM, Koppelman GH, Zheng SL, Meyers DA, Bleecker ER, Postma DS. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy. 2004 May;34(5):757-60. doi: 10.1111/j.1365-2222.2004.1938.x.

    PMID: 15144468BACKGROUND

  • Meyers DA, Postma DS, Stine OC, Koppelman GH, Ampleford EJ, Jongepier H, Howard TD, Bleecker ER. Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol. 2005 Jun;115(6):1169-75. doi: 10.1016/j.jaci.2005.01.070.

    PMID: 15940130BACKGROUND

  • Postma DS, Meyers DA, Jongepier H, Howard TD, Koppelman GH, Bleecker ER. Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med. 2005 Aug 15;172(4):446-52. doi: 10.1164/rccm.200407-864OC. Epub 2005 May 18.

    PMID: 15901612BACKGROUND

  • Oostendorp J, Postma DS, Volders H, Jongepier H, Kauffman HF, Boezen HM, Meyers DA, Bleecker ER, Nelemans SA, Zaagsma J, Meurs H. Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes. Am J Respir Crit Care Med. 2005 Aug 1;172(3):322-8. doi: 10.1164/rccm.200409-1162OC. Epub 2005 May 5.

    PMID: 15879418BACKGROUND

  • Teeter JG, Bleecker ER. Mechanisms of asthma. Curr Opin Pulm Med. 1996 Jan;2(1):23-8.

    PMID: 9363111BACKGROUND

MeSH Terms

Conditions

AsthmaLung Diseases

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Deborah Meyers

    Wake Forest University

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

July 1, 1994

Primary Completion

May 1, 2008

Study Completion

May 1, 2008

Last Updated

July 12, 2016

Record last verified: 2008-07