University of North Carolina Alumni Heart Study

NCT00005398 | Active Not Recruiting

• 5 other identifiers: Pro00013233R01HL055356P01HL036587R01MH0660794311
• Study Type: observational
• Target: 6,340
• Locations: 1 country
• Sites: 1

Brief Summary

To continue surveillance of the participants in the University of North Carolina Alumni Heart Study, which tests the hypothesis that hostility and related psychosocial factors are involved in the pathogenesis of coronary heart disease.

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Depression

Outcome Measures

Primary Outcomes (1)

• Coronary Heart Disease

  This is a descriptive cohort study

  approximately 30 years

Study Arms (1)

1; no experimental groups in this study

Observational cohort study

Other: There is no intervention

Interventions

There is no intervention OTHER

No applicable

1; no experimental groups in this study

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

participants in the University of North Carolina Alumni Heart Study

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Duke University: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

Duke University, Behavioral Medicine Research Center

Durham, North Carolina, 27705, United States

Location

Related Publications (21)

• Brummett BH, Barefoot JC, Feaganes JR, Yen S, Bosworth HB, Williams RB, Siegler IC. Hostility in marital dyads: associations with depressive symptoms. J Behav Med. 2000 Feb;23(1):95-105. doi: 10.1023/a:1005424405056.

  PMID: 10749013 BACKGROUND

• Barefoot JC, Heitmann BL, Helms MJ, Williams RB, Surwit RS, Siegler IC. Symptoms of depression and changes in body weight from adolescence to mid-life. Int J Obes Relat Metab Disord. 1998 Jul;22(7):688-94. doi: 10.1038/sj.ijo.0800647.

  PMID: 9705031 BACKGROUND

• Bastian LA, Couchman GM, Rimer BK, McBride CM, Feaganes JR, Siegler IC. Perceptions of menopausal stage and patterns of hormone replacement therapy use. J Womens Health. 1997 Aug;6(4):467-75. doi: 10.1089/jwh.1997.6.467.

  PMID: 9279835 BACKGROUND

• Luecken LJ, Suarez EC, Kuhn CM, Barefoot JC, Blumenthal JA, Siegler IC, Williams RB. Stress in employed women: impact of marital status and children at home on neurohormone output and home strain. Psychosom Med. 1997 Jul-Aug;59(4):352-9. doi: 10.1097/00006842-199707000-00003.

  PMID: 9251153 BACKGROUND

• Herbst JH, McCrae RR, Costa PT Jr, Feaganes JR, Siegler IC. Self-perceptions of stability and change in personality at midlife: the UNC Alumni Heart Study. Assessment. 2000 Dec;7(4):379-88. doi: 10.1177/107319110000700406.

  PMID: 11151963 BACKGROUND

• Costa PT Jr, Herbst JH, McCrae RR, Siegler IC. Personality at midlife: stability, intrinsic maturation, and response to life events. Assessment. 2000 Dec;7(4):365-78. doi: 10.1177/107319110000700405.

  PMID: 11151962 BACKGROUND

• Siegler IC, Brummett BH. Associations among NEO personality assessments and well-being at midlife: facet-level analyses. Psychol Aging. 2000 Dec;15(4):710-4. doi: 10.1037//0882-7974.15.4.710.

  PMID: 11144330 BACKGROUND

• Brummett BH, Maynard KE, Haney TL, Siegler IC, Barefoot JC. Reliability of interview-assessed hostility ratings across mode of assessment and time. J Pers Assess. 2000 Oct;75(2):225-36. doi: 10.1207/S15327752JPA7502_4.

  PMID: 11020141 BACKGROUND

• McPherson RS, Feaganes JR, Siegler IC. Measurement of dietary intake in the UNC Alumni Heart Study. University of North Carolina. Prev Med. 2000 Jul;31(1):56-67. doi: 10.1006/pmed.2000.0679.

  PMID: 10896844 BACKGROUND

• Barefoot JC, Gronbaek M, Feaganes JR, McPherson RS, Williams RB, Siegler IC. Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study. Am J Clin Nutr. 2002 Aug;76(2):466-72. doi: 10.1093/ajcn/76.2.466.

  PMID: 12145024 BACKGROUND

• Siegler IC, Bastian LA, Steffens DC, Bosworth HB, Costa PT. Behavioral medicine and aging. J Consult Clin Psychol. 2002 Jun;70(3):843-51. doi: 10.1037//0022-006x.70.3.843.

  PMID: 12090387 BACKGROUND

• Bosworth HB, Siegler IC. Terminal change in cognitive function: an updated review of longitudinal studies. Exp Aging Res. 2002 Jul-Sep;28(3):299-315. doi: 10.1080/03610730290080344.

  PMID: 12079580 BACKGROUND

• Vitaliano PP, Scanlan JM, Zhang J, Savage MV, Hirsch IB, Siegler IC. A path model of chronic stress, the metabolic syndrome, and coronary heart disease. Psychosom Med. 2002 May-Jun;64(3):418-35. doi: 10.1097/00006842-200205000-00006.

  PMID: 12021416 BACKGROUND

• Surwit RS, Williams RB, Siegler IC, Lane JD, Helms M, Applegate KL, Zucker N, Feinglos MN, McCaskill CM, Barefoot JC. Hostility, race, and glucose metabolism in nondiabetic individuals. Diabetes Care. 2002 May;25(5):835-9. doi: 10.2337/diacare.25.5.835.

  PMID: 11978677 BACKGROUND

• Brummett BH, Barefoot JC, Vitaliano PP, Siegler IC. Associations among social support, income, and symptoms of depression in an educated sample: the UNC Alumni Heart Study. Int J Behav Med. 2003;10(3):239-50. doi: 10.1207/s15327558ijbm1003_04.

  PMID: 14525719 BACKGROUND

• Siegler IC, Costa PT, Brummett BH, Helms MJ, Barefoot JC, Williams RB, Dahlstrom WG, Kaplan BH, Vitaliano PP, Nichaman MZ, Day RS, Rimer BK. Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk status. Psychosom Med. 2003 Sep-Oct;65(5):738-45. doi: 10.1097/01.psy.0000088583.25140.9c.

  PMID: 14508014 BACKGROUND

• Brummett BH, Siegler IC, McQuoid DR, Svenson IK, Marchuk DA, Steffens DC. Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender. Psychiatr Genet. 2003 Mar;13(1):13-8. doi: 10.1097/00041444-200303000-00002.

  PMID: 12605095 BACKGROUND

• Boyle SH, Williams RB, Mark DB, Brummett BH, Siegler IC, Barefoot JC. Hostility, age, and mortality in a sample of cardiac patients. Am J Cardiol. 2005 Jul 1;96(1):64-6. doi: 10.1016/j.amjcard.2005.02.046.

  PMID: 15979435 BACKGROUND

• Applegate KL, Keefe FJ, Siegler IC, Bradley LA, McKee DC, Cooper KS, Riordan P. Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study. J Pain. 2005 Feb;6(2):92-7. doi: 10.1016/j.jpain.2004.11.001.

  PMID: 15694875 BACKGROUND

• Brummett BH, Boyle SH, Siegler IC, Williams RB, Mark DB, Barefoot JC. Ratings of positive and depressive emotion as predictors of mortality in coronary patients. Int J Cardiol. 2005 Apr 20;100(2):213-6. doi: 10.1016/j.ijcard.2004.06.016.

  PMID: 15823627 BACKGROUND

• Brummett BH, Mark DB, Siegler IC, Williams RB, Babyak MA, Clapp-Channing NE, Barefoot JC. Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms. Psychosom Med. 2005 Jan-Feb;67(1):40-5. doi: 10.1097/01.psy.0000149257.74854.b7.

  PMID: 15673622 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Depression

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases; Behavioral Symptoms; Behavior

Study Officials

• Ilene C. Siegler, PhD, MPH

  Duke University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: May 1, 1996
• Primary Completion (Estimated): May 1, 2026
• Study Completion (Estimated): May 1, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

US (1)