Genetics of the Metabolic Syndrome in Japanese Americans

NCT00005374 | Completed

• 2 other identifiers: 4268R01HL050268
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To investigate the genetic influence of candidate gene polymorphisms on risk factors for the metabolic insulin resistance syndrome in Japanese American sibships and kindreds. The original grant in 1994 had as its objective to understand the genetic epidemiology of coronary heart disease (CHD) risk factors in Japanese- American families with probands living in Seattle, Washington.

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases; Insulin Resistance; Diabetes Mellitus, Non-insulin Dependent; Diabetes Mellitus; Metabolic Syndrome X

Eligibility Criteria

• Age: Up to 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Washington: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (6)

• Austin MA. Genetic epidemiology of dyslipidaemia and atherosclerosis. Ann Med. 1996 Oct;28(5):459-63. doi: 10.3109/07853899608999108.

  PMID: 8949979 BACKGROUND

• Austin MA, Rodriguez BL, McKnight B, McNeely MJ, Edwards KL, Curb JD, Sharp DS. Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men. Am J Cardiol. 2000 Aug 15;86(4):412-6. doi: 10.1016/s0002-9149(00)00956-5.

  PMID: 10946034 BACKGROUND

• Austin MA. Ethical issues in human genome epidemiology: a case study based on the Japanese American Family Study in Seattle, Washington. Am J Epidemiol. 2002 Apr 1;155(7):585-92. doi: 10.1093/aje/155.7.585.

  PMID: 11914185 BACKGROUND

• Austin MA, Talmud PJ, Farin FM, Nickerson DA, Edwards KL, Leonetti D, McNeely MJ, Viernes HM, Humphries SE, Fujimoto WY. Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans. Biochim Biophys Acta. 2004 Jan 20;1688(1):1-9. doi: 10.1016/j.bbadis.2003.10.003.

  PMID: 14732475 BACKGROUND

• Austin MA, Zhang C, Humphries SE, Chandler WL, Talmud PJ, Edwards KL, Leonetti DL, McNeely MJ, Fujimoto WY. Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans. Ann Hum Genet. 2004 May;68(Pt 3):179-88. doi: 10.1046/j.1529-8817.2004.00078.x.

  PMID: 15180698 BACKGROUND

• Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ, Humphries SE, Fujimoto WY. Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans. Diabetes. 2004 Apr;53(4):1166-9. doi: 10.2337/diabetes.53.4.1166.

  PMID: 15047637 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases; Insulin Resistance; Diabetes Mellitus, Type 2; Diabetes Mellitus; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Melissa Austin

  University of Washington

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: January 1, 1994
• Study Completion: May 1, 2004
• Last Updated: February 10, 2016

Record last verified: 2005-03