Homocysteine and Progression of Atherosclerosis

NCT00005338 | Completed

• 2 other identifiers: 4200R01HL045267
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

In the first phase, to establish the relationship of progression of peripheral vascular disease (PVD) to plasma homocysteine. In the second phase, to conduct a randomized, controlled trial of folic acid treatment of plasma homocysteine in peripheral vascular disease.

Conditions

Cardiovascular Diseases; Peripheral Vascular Diseases; Atherosclerosis; Cerebrovascular Disorders; Myocardial Infarction; Heart Diseases; Hyperhomocysteinemia

Eligibility Criteria

• Age: Up to 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (21)

• McLafferty RB, Moneta GL, Passman MA, Brant BM, Taylor LM Jr, Porter JM. Late clinical and hemodynamic sequelae of isolated calf vein thrombosis. J Vasc Surg. 1998 Jan;27(1):50-6; discussion 56-7. doi: 10.1016/s0741-5214(98)70291-5.

  PMID: 9474082 BACKGROUND

• Nehler MR, Taylor LM Jr, Porter JM. Homocysteinemia as a risk factor for atherosclerosis: a review. Cardiovasc Surg. 1997 Dec;5(6):559-67. doi: 10.1016/s0967-2109(97)00062-8.

  PMID: 9423939 BACKGROUND

• Abou-Zamzam AM Jr, Lee RW, Moneta GL, Taylor LM Jr, Porter JM. Functional outcome after infrainguinal bypass for limb salvage. J Vasc Surg. 1997 Feb;25(2):287-95; discussion 295-7. doi: 10.1016/s0741-5214(97)70350-1.

  PMID: 9052563 BACKGROUND

• Lee RW, Taylor LM Jr, Landry GJ, Goodnight SH, Moneta GL, Edwards JM, Yeager RA, Porter JM. Prospective comparison of infrainguinal bypass grafting in patients with and without antiphospholipid antibodies. J Vasc Surg. 1996 Oct;24(4):524-31; discussion 531-3. doi: 10.1016/s0741-5214(96)70068-x.

  PMID: 8911401 BACKGROUND

• McLafferty RB, Moneta GL, Masser PA, Taylor LM Jr, Porter JM. Progression of atherosclerosis in arteries distal to lower extremity revascularizations. J Vasc Surg. 1995 Oct;22(4):450-5; discussion 455-6. doi: 10.1016/s0741-5214(95)70014-5.

  PMID: 7563406 BACKGROUND

• McLafferty RB, Moneta GL, Taylor LM Jr, Porter JM. Ability of ankle-brachial index to detect lower-extremity atherosclerotic disease progression. Arch Surg. 1997 Aug;132(8):836-40; discussion 840-1. doi: 10.1001/archsurg.1997.01430320038005.

  PMID: 9267266 BACKGROUND

• Deloughery TG, Evans A, Sadeghi A, McWilliams J, Henner WD, Taylor LM Jr, Press RD. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease. Circulation. 1996 Dec 15;94(12):3074-8. doi: 10.1161/01.cir.94.12.3074.

  PMID: 8989110 BACKGROUND

• Nehler MR, Moneta GL, Lee RW, Edwards JM, Taylor LM Jr, Porter JM. Improving selection of patients with less than 60% asymptomatic internal carotid artery stenosis for follow-up carotid artery duplex scanning. J Vasc Surg. 1996 Oct;24(4):580-5; discussion 585-7. doi: 10.1016/s0741-5214(96)70073-3.

  PMID: 8911406 BACKGROUND

• Masser PA, Taylor LM Jr, Porter JM. Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis. Ann Thorac Surg. 1994 Oct;58(4):1240-6. doi: 10.1016/0003-4975(94)90522-3.

  PMID: 7944799 BACKGROUND

• Taylor LM Jr, Chitwood RW, Dalman RL, Sexton G, Goodnight SH, Porter JM. Antiphospholipid antibodies in vascular surgery patients. A cross-sectional study. Ann Surg. 1994 Oct;220(4):544-50; discussion 550-1. doi: 10.1097/00000658-199410000-00012.

  PMID: 7944664 BACKGROUND

• Taylor LM Jr, Park TC, Edwards JM, Yeager RA, McConnell DC, Moneta GA, Porter JM. Acute disruption of polytetrafluoroethylene grafts adjacent to axillary anastomoses: a complication of axillofemoral grafting. J Vasc Surg. 1994 Oct;20(4):520-6; discussion 526-8. doi: 10.1016/0741-5214(94)90276-3.

  PMID: 7933253 BACKGROUND

• Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, Ji J, Otto JM, Taylor LM Jr. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem. 1994 Jun;40(6):873-81.

  PMID: 8087981 BACKGROUND

• Taylor LM Jr, Porter JM. Elevated plasma homocysteine as a risk factor for atherosclerosis. Semin Vasc Surg. 1993 Mar;6(1):36-45. No abstract available.

  PMID: 8252227 BACKGROUND

• Nicoloff AD, Taylor LM Jr, McLafferty RB, Moneta GL, Porter JM. Patient recovery after infrainguinal bypass grafting for limb salvage. J Vasc Surg. 1998 Feb;27(2):256-63; discussion 264-6. doi: 10.1016/s0741-5214(98)70356-8.

  PMID: 9510280 BACKGROUND

• Taylor LM Jr, Moneta GL, Sexton GJ, Schuff RA, Porter JM. Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease. J Vasc Surg. 1999 Jan;29(1):8-19; discussion 19-21. doi: 10.1016/s0741-5214(99)70345-9.

  PMID: 9925456 BACKGROUND

• Cipolla MJ, Williamson WK, Nehler ML, Taylor LM Jr, Porter JM. The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: the role of the endothelium and reactive oxygen species. J Vasc Surg. 2000 Apr;31(4):751-9. doi: 10.1067/mva.2000.103797.

  PMID: 10753283 BACKGROUND

• Lovelace TD, Moneta GL, Abou-Zamzam AM Jr, Edwards JM, Yeager RA, Landry GJ, Taylor LM Jr, Porter JM. Optimizing duplex follow-up in patients with an asymptomatic internal carotid artery stenosis of less than 60%. J Vasc Surg. 2001 Jan;33(1):56-61. doi: 10.1067/mva.2001.112303.

  PMID: 11137924 BACKGROUND

• Nicoloff AD, Taylor LM Jr, Sexton GJ, Schuff RA, Edwards JM, Yeager RA, Landry GJ, Moneta GL, Porter JM; Homocysteine and Progression of Atherosclerosis Study Investigators. Relationship between site of initial symptoms and subsequent progression of disease in a prospective study of atherosclerosis progression in patients receiving long-term treatment for symptomatic peripheral arterial disease. J Vasc Surg. 2002 Jan;35(1):38-46; discussion 46-7.

  PMID: 11802131 BACKGROUND

• Giswold ME, Landry GJ, Sexton GJ, Yeager RA, Edwards JM, Taylor LM Jr, Moneta GL. Modifiable patient factors are associated with reverse vein graft occlusion in the era of duplex scan surveillance. J Vasc Surg. 2003 Jan;37(1):47-53. doi: 10.1067/mva.2003.4.

  PMID: 12514577 BACKGROUND

• Cook JW, Taylor LM, Orloff SL, Landry GJ, Moneta GL, Porter JM. Homocysteine and arterial disease. Experimental mechanisms. Vascul Pharmacol. 2002 May;38(5):293-300. doi: 10.1016/s1537-1891(02)00254-9.

  PMID: 12487034 BACKGROUND

• Taylor LM Jr. Elevated plasma homocysteine as risk factor for peripheral arterial disease--what is the evidence? Semin Vasc Surg. 2003 Sep;16(3):215-22. doi: 10.1016/s0895-7967(03)00027-9.

  PMID: 12975761 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Peripheral Vascular Diseases; Atherosclerosis; Cerebrovascular Disorders; Myocardial Infarction; Heart Diseases; Hyperhomocysteinemia

Condition Hierarchy (Ancestors)

Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Myocardial Ischemia; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Amino Acid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Malabsorption Syndromes; Metabolic Diseases; Nutritional and Metabolic Diseases; Vitamin B Deficiency; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders

Study Officials

• Lloyd Taylor

  Oregon Health and Science University

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: August 1, 1991
• Study Completion: August 1, 2004
• Last Updated: February 18, 2016

Record last verified: 2004-12