NCT00005329

Brief Summary

To test the hypothesis that low levels of free protein S, a natural anticoagulant protein in plasma, were associated with an increased incidence of myocardial infarction in middle aged men and women.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started May 1992

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 1992

Completed
4.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 1997

Completed
3.2 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

May 13, 2016

Status Verified

March 1, 2005

First QC Date

May 25, 2000

Last Update Submit

May 12, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesMyocardial Infarction

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (3)

  • Eichner JE, Moore WE, McKee PA, Schechter E, Reynolds DW, Qi H, Comp PC. Fibrinogen levels in women having coronary angiography. Am J Cardiol. 1996 Jul 1;78(1):15-8. doi: 10.1016/s0002-9149(96)00219-6.

    PMID: 8712111BACKGROUND

  • Thorisdottir H, Evans JA, Schwartz HJ, Comp P, Haluschak J, Ratnoff OD. Some clotting factors in plasma during danazol therapy: free and total protein S, but not C4b-binding protein, are elevated by danazol therapy. J Lab Clin Med. 1992 Jun;119(6):698-701.

    PMID: 1534346BACKGROUND

  • Rudnicka AR, Miller GJ, Nelson T, Doray D, Comp PC. An association between plasma free protein s concentration and risk of coronary heart disease in middle-aged men. Thromb Res. 2001 Jan 15;101(2):1-11. doi: 10.1016/s0049-3848(00)00379-0.

    PMID: 11342201BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesMyocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Officials

  • Philip Comp

    University of Oklahoma Hlth Sciences Ctr

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

May 1, 1992

Study Completion

March 1, 1997

Last Updated

May 13, 2016

Record last verified: 2005-03