NCT00005328

Brief Summary

To identify the early emergence and stability of children's hostile behaviors and their associated psychophysiological responses to behavioral challenges, which are possible risk factors for cardiovascular diseases in adulthood; and to specify their determinants and consequences.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
184

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 1980

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1980

Completed
20.2 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
8.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2008

Completed
Last Updated

January 17, 2013

Status Verified

January 1, 2013

Enrollment Period

28.4 years

First QC Date

May 25, 2000

Last Update Submit

January 16, 2013

Conditions

Outcome Measures

Primary Outcomes (1)

  • Development of hostility, anxiety, and heightened cardiovascular responsivity to stress affect the early development of vascular stiffness and left ventricular mass.

    Adolescents' socioeconomic status and ethnicity affect their exposure to psychological stress, including discrimination, which, in turn, is thought to lead to the development of the propensity to be vigilant for possible threat, to view ambiguous situations as potentially harmful, and to mistrust others. These cognitive propensities may become more automatic with development and lead to stable traits of hostility, anxiety, and heightened cardiovascular responsivity to stress. These traits may then affect the early development of vascular stiffness and left ventricular mass.

    3 years

Eligibility Criteria

Age9 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)
Sampling MethodNon-Probability Sample
Study Population

Adolescents from one high school in Pittsburgh

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (44)

  • Gump BB, Matthews KA. Vigilance and cardiovascular reactivity to subsequent stressors in men: a preliminary study. Health Psychol. 1998 Jan;17(1):93-6. doi: 10.1037//0278-6133.17.1.93.

    PMID: 9459076BACKGROUND
  • Matthews KA, Gump BB, Block DR, Allen MT. Does background stress heighten or dampen children's cardiovascular responses to acute stress? Psychosom Med. 1997 Sep-Oct;59(5):488-96. doi: 10.1097/00006842-199709000-00005.

    PMID: 9316181BACKGROUND
  • Allen MT, Matthews KA, Sherman FS. Cardiovascular reactivity to stress and left ventricular mass in youth. Hypertension. 1997 Oct;30(4):782-7. doi: 10.1161/01.hyp.30.4.782.

    PMID: 9336373BACKGROUND
  • Matthews KA. Origins of the Type A (coronary-prone) behavior pattern. J S C Med Assoc. 1983 Oct;79(10):551-6. No abstract available.

    PMID: 6580505BACKGROUND
  • Matthews KA, Rosenman RH, Dembroski TM, Harris EL, MacDougall JM. Familial resemblance in components of the type A behavior pattern: a reanalysis of the California type A twin study. Psychosom Med. 1984 Nov-Dec;46(6):512-22. doi: 10.1097/00006842-198411000-00004.

    PMID: 6542684BACKGROUND
  • Jennings JR, Matthews KA. The impatience of youth: phasic cardiovascular response in type A and type B elementary school-aged boys. Psychosom Med. 1984 Nov-Dec;46(6):498-511. doi: 10.1097/00006842-198411000-00003.

    PMID: 6514950BACKGROUND
  • Matthews KA, Jennings JR. Cardiovascular responses of boys exhibiting the type A behavior pattern. Psychosom Med. 1984 Nov-Dec;46(6):484-97. doi: 10.1097/00006842-198411000-00002.

    PMID: 6514949BACKGROUND
  • Matthews KA, Avis NE. Stability of overt Type A behaviors in children: results from a one-year longitudinal study. Child Dev. 1983 Dec;54(6):1507-12.

    PMID: 6661943BACKGROUND
  • Siegel JM, Matthews KA, Leitch CJ. Blood pressure variability and the type A behavior pattern in adolescence. J Psychosom Res. 1983;27(4):265-72. doi: 10.1016/0022-3999(83)90048-x.

    PMID: 6620203BACKGROUND
  • Matthews KA, Volkin JI. Efforts to excel and the type A behavior pattern in children. Child Dev. 1981;52(4):1283-9.

    PMID: 7318523BACKGROUND
  • Siegel JM, Matthews KA, Leitch CJ. Validation of the type A interview assessment of adolescents: a multidimensional approach. Psychosom Med. 1981 Aug;43(4):311-21. doi: 10.1097/00006842-198108000-00004.

    PMID: 7280160BACKGROUND
  • Matthews KA. Coronary heart disease and type A behaviors: update on and alternative to the Booth-Kewley and Friedman (1987) quantitative review. Psychol Bull. 1988 Nov;104(3):373-80. doi: 10.1037/0033-2909.104.3.373. No abstract available.

    PMID: 3062658BACKGROUND
  • Woodall KL, Matthews KA. Familial environment associated with type A behaviors and psychophysiological responses to stress in children. Health Psychol. 1989;8(4):403-26. doi: 10.1037//0278-6133.8.4.403.

    PMID: 2583078BACKGROUND
  • Matthews KA, Manuck SB, Stoney CM, Rakaczky CJ, McCann BS, Saab PG, Woodall KL, Block DR, Visintainer PF, Engebretson TO. Familial aggregation of blood pressure and heart rate responses during behavioral stress. Psychosom Med. 1988 Jul-Aug;50(4):341-52. doi: 10.1097/00006842-198807000-00003.

    PMID: 3413268BACKGROUND
  • Stoney CM, Matthews KA. Parental history of hypertension and myocardial infarction predicts cardiovascular responses to behavioral stressors in middle-aged men and women. Psychophysiology. 1988 May;25(3):269-77. doi: 10.1111/j.1469-8986.1988.tb01241.x. No abstract available.

    PMID: 3406328BACKGROUND
  • Visintainer PF, Matthews KA. Stability of overt type A behaviors in children: results from a two- and five-year longitudinal study. Child Dev. 1987 Dec;58(6):1586-91.

    PMID: 3691203BACKGROUND
  • Matthews KA, Rakaczky CJ, Stoney CM, Manuck SB. Are cardiovascular responses to behavioral stressors a stable individual difference variable in childhood? Psychophysiology. 1987 Jul;24(4):464-73. doi: 10.1111/j.1469-8986.1987.tb00318.x. No abstract available.

    PMID: 3615758BACKGROUND
  • Matthews KA, Stoney CM, Rakaczky CJ, Jamison W. Family characteristics and school achievements of type A children. Health Psychol. 1986;5(5):453-67. doi: 10.1037//0278-6133.5.5.453.

    PMID: 3757993BACKGROUND
  • Murray DM, Matthews KA, Blake SM, Prineas RJ, Gillum RF. Type A behavior in children: demographic, behavioral, and physiological correlates. Health Psychol. 1986;5(2):159-69. doi: 10.1037//0278-6133.5.2.159.

    PMID: 3732229BACKGROUND
  • Matthews KA, Manuck SB, Saab PG. Cardiovascular responses of adolescents during a naturally occurring stressor and their behavioral and psychophysiological predictors. Psychophysiology. 1986 Mar;23(2):198-209. doi: 10.1111/j.1469-8986.1986.tb00618.x. No abstract available.

    PMID: 3704076BACKGROUND
  • Matthews KA, Woodall KL, Allen MT. Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension. 1993 Oct;22(4):479-85. doi: 10.1161/01.hyp.22.4.479.

    PMID: 8406652BACKGROUND
  • Woodall KL, Matthews KA. Changes in and stability of hostile characteristics: results from a 4-year longitudinal study of children. J Pers Soc Psychol. 1993 Mar;64(3):491-9. doi: 10.1037//0022-3514.64.3.491.

    PMID: 8468674BACKGROUND
  • Porges SW, Matthews KA, Pauls DL. The biobehavioral interface in behavioral pediatrics. Pediatrics. 1992 Nov;90(5 Pt 2):789-97. No abstract available.

    PMID: 1437409BACKGROUND
  • Matthews KA, Woodall KL, Engebretson TO, McCann BS, Stoney CM, Manuck SB, Saab PG. Influence of age, sex, and family on Type A and hostile attitudes and behaviors. Health Psychol. 1992;11(5):317-23. doi: 10.1037//0278-6133.11.5.317.

    PMID: 1425549BACKGROUND
  • Engebretson TO, Matthews KA. Dimensions of hostility in men, women, and boys: relationships to personality and cardiovascular responses to stress. Psychosom Med. 1992 May-Jun;54(3):311-23. doi: 10.1097/00006842-199205000-00007.

    PMID: 1620807BACKGROUND
  • Matthews KA, Woodall KL, Stoney CM. Changes in and stability of cardiovascular responses to behavioral stress: results from a four-year longitudinal study of children. Child Dev. 1990 Aug;61(4):1134-44.

    PMID: 2209183BACKGROUND
  • Allen MT, Matthews KA. Hemodynamic responses to laboratory stressors in children and adolescents: the influences of age, race, and gender. Psychophysiology. 1997 May;34(3):329-39. doi: 10.1111/j.1469-8986.1997.tb02403.x.

    PMID: 9175447BACKGROUND
  • Matthews KA, Woodall KL, Kenyon K, Jacob T. Negative family environment as a predictor of boys' future status on measures of hostile attitudes, interview behavior, and anger expression. Health Psychol. 1996 Jan;15(1):30-7. doi: 10.1037//0278-6133.15.1.30.

    PMID: 8788538BACKGROUND
  • Adler N, Matthews K. Health psychology: why do some people get sick and some stay well? Annu Rev Psychol. 1994;45:229-59. doi: 10.1146/annurev.ps.45.020194.001305. No abstract available.

    PMID: 8135503BACKGROUND
  • Lassner JB, Matthews KA, Stoney CM. Are cardiovascular reactors to asocial stress also reactors to social stress? J Pers Soc Psychol. 1994 Jan;66(1):69-77. doi: 10.1037//0022-3514.66.1.69.

    PMID: 8126652BACKGROUND
  • Gump BB, Matthews KA, Raikkonen K. Modeling relationships among socioeconomic status, hostility, cardiovascular reactivity, and left ventricular mass in African American and White children. Health Psychol. 1999 Mar;18(2):140-50. doi: 10.1037//0278-6133.18.2.140.

    PMID: 10194049BACKGROUND
  • Allen MT, Matthews KA, Kenyon KL. The relationships of resting baroreflex sensitivity, heart rate variability and measures of impulse control in children and adolescents. Int J Psychophysiol. 2000 Aug;37(2):185-94. doi: 10.1016/s0167-8760(00)00089-1.

    PMID: 10832005BACKGROUND
  • Salomon K, Matthews KA, Allen MT. Patterns of sympathetic and parasympathetic reactivity in a sample of children and adolescents. Psychophysiology. 2000 Nov;37(6):842-9.

    PMID: 11117464BACKGROUND
  • Chen E, Matthews KA. Cognitive appraisal biases: an approach to understanding the relation between socioeconomic status and cardiovascular reactivity in children. Ann Behav Med. 2001 Spring;23(2):101-11. doi: 10.1207/S15324796ABM2302_4.

    PMID: 11394551BACKGROUND
  • Chen E, Matthews KA, Boyce WT. Socioeconomic differences in children's health: how and why do these relationships change with age? Psychol Bull. 2002 Mar;128(2):295-329. doi: 10.1037/0033-2909.128.2.295.

    PMID: 11931521BACKGROUND
  • Matthews KA, Salomon K, Kenyon K, Allen MT. Stability of children's and adolescents' hemodynamic responses to psychological challenge: a three-year longitudinal study of a multiethnic cohort of boys and girls. Psychophysiology. 2002 Nov;39(6):826-34. doi: 10.1111/1469-8986.3960826.

    PMID: 12462510BACKGROUND
  • Ewart CK, Jorgensen RS, Suchday S, Chen E, Matthews KA. Measuring stress resilience and coping in vulnerable youth: the Social Competence Interview. Psychol Assess. 2002 Sep;14(3):339-52. doi: 10.1037//1040-3590.14.3.339.

    PMID: 12214440BACKGROUND
  • Chen E, Matthews KA. Development of the cognitive appraisal and understanding of social events (CAUSE) videos. Health Psychol. 2003 Jan;22(1):106-10. doi: 10.1037//0278-6133.22.1.106.

    PMID: 12558208BACKGROUND
  • Gallo LC, Matthews KA. Understanding the association between socioeconomic status and physical health: do negative emotions play a role? Psychol Bull. 2003 Jan;129(1):10-51. doi: 10.1037/0033-2909.129.1.10.

    PMID: 12555793BACKGROUND
  • Matthews KA, Salomon K, Brady SS, Allen MT. Cardiovascular reactivity to stress predicts future blood pressure in adolescence. Psychosom Med. 2003 May-Jun;65(3):410-5. doi: 10.1097/01.psy.0000057612.94797.5f.

    PMID: 12764214BACKGROUND
  • Troxel WM, Matthews KA. What are the costs of marital conflict and dissolution to children's physical health? Clin Child Fam Psychol Rev. 2004 Mar;7(1):29-57. doi: 10.1023/b:ccfp.0000020191.73542.b0.

    PMID: 15119687BACKGROUND
  • Chen E, Langer DA, Raphaelson YE, Matthews KA. Socioeconomic status and health in adolescents: the role of stress interpretations. Child Dev. 2004 Jul-Aug;75(4):1039-52. doi: 10.1111/j.1467-8624.2004.00724.x.

    PMID: 15260863BACKGROUND
  • Goldbacher EM, Matthews KA, Salomon K. Central adiposity is associated with cardiovascular reactivity to stress in adolescents. Health Psychol. 2005 Jul;24(4):375-84. doi: 10.1037/0278-6133.24.4.375.

    PMID: 16045373BACKGROUND
  • Matthews KA, Salomon K, Kenyon K, Zhou F. Unfair treatment, discrimination, and ambulatory blood pressure in black and white adolescents. Health Psychol. 2005 May;24(3):258-65. doi: 10.1037/0278-6133.24.3.258.

    PMID: 15898861BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart Diseases

Study Officials

  • Karen Matthews, PhD

    University of Pittsburgh

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Distinguished Professor

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

April 1, 1980

Primary Completion

August 1, 2008

Study Completion

August 1, 2008

Last Updated

January 17, 2013

Record last verified: 2013-01