Mechanisms Underlying Psychosocial Associations With Ischemic Heart Disease (Kuopio)

NCT00005260 | Completed

• 2 other identifiers: 1143R01HL044199
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To examine the relationships among psychosocial factors and carotid atherosclerosis, myocardial ischemia, arrhythmias, and thrombosis.

Conditions

Cardiovascular Diseases; Carotid Artery Diseases; Arrhythmia; Myocardial Ischemia; Thrombosis; Heart Diseases; Atherosclerosis

Eligibility Criteria

• Age: Up to 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (76)

• Wilson TW, Cohen RD, Lachenbruch PA, Wu M, Kaplan GA, Salonen JT. Is the relationship between supine blood pressure and postural changes in blood pressure artefactual? Results from the Kuopio Ischemic Heart Disease Risk Factor Study. J Hypertens. 1995 Apr;13(4):421-6.

  PMID: 7629402 BACKGROUND

• Lynch JW, Everson SA, Kaplan GA, Salonen R, Salonen JT. Does low socioeconomic status potentiate the effects of heightened cardiovascular responses to stress on the progression of carotid atherosclerosis? Am J Public Health. 1998 Mar;88(3):389-94. doi: 10.2105/ajph.88.3.389.

  PMID: 9518969 BACKGROUND

• Salonen JT, Lakka TA, Lakka HM, Valkonen VP, Everson SA, Kaplan GA. Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes. 1998 Feb;47(2):270-5. doi: 10.2337/diab.47.2.270.

  PMID: 9519724 BACKGROUND

• Kamarck TW, Everson SA, Kaplan GA, Manuck SB, Jennings JR, Salonen R, Salonen JT. Exaggerated blood pressure responses during mental stress are associated with enhanced carotid atherosclerosis in middle-aged Finnish men: findings from the Kuopio Ischemic Heart Disease Study. Circulation. 1997 Dec 2;96(11):3842-8. doi: 10.1161/01.cir.96.11.3842.

  PMID: 9403606 BACKGROUND

• Kauhanen J, Kaplan GA, Goldberg DE, Salonen JT. Beer binging and mortality: results from the Kuopio ischaemic heart disease risk factor study, a prospective population based study. BMJ. 1997 Oct 4;315(7112):846-51. doi: 10.1136/bmj.315.7112.846.

  PMID: 9353504 BACKGROUND

• Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med. 1996 Jun 24;156(12):1307-14.

  PMID: 8651839 BACKGROUND

• Everson SA, Kaplan GA, Goldberg DE, Salonen R, Salonen JT. Hopelessness and 4-year progression of carotid atherosclerosis. The Kuopio Ischemic Heart Disease Risk Factor Study. Arterioscler Thromb Vasc Biol. 1997 Aug;17(8):1490-5. doi: 10.1161/01.atv.17.8.1490.

  PMID: 9301625 BACKGROUND

• Everson SA, Kauhanen J, Kaplan GA, Goldberg DE, Julkunen J, Tuomilehto J, Salonen JT. Hostility and increased risk of mortality and acute myocardial infarction: the mediating role of behavioral risk factors. Am J Epidemiol. 1997 Jul 15;146(2):142-52. doi: 10.1093/oxfordjournals.aje.a009245.

  PMID: 9230776 BACKGROUND

• Lynch J, Krause N, Kaplan GA, Salonen R, Salonen JT. Workplace demands, economic reward, and progression of carotid atherosclerosis. Circulation. 1997 Jul 1;96(1):302-7. doi: 10.1161/01.cir.96.1.302.

  PMID: 9236449 BACKGROUND

• Jennings JR, Kamarck T, Manuck S, Everson SA, Kaplan G, Salonen JT. Aging or disease? Cardiovascular reactivity in Finnish men over the middle years. Psychol Aging. 1997 Jun;12(2):225-38. doi: 10.1037//0882-7974.12.2.225.

  PMID: 9189982 BACKGROUND

• Lynch J, Krause N, Kaplan GA, Tuomilehto J, Salonen JT. Workplace conditions, socioeconomic status, and the risk of mortality and acute myocardial infarction: the Kuopio Ischemic Heart Disease Risk Factor Study. Am J Public Health. 1997 Apr;87(4):617-22. doi: 10.2105/ajph.87.4.617.

  PMID: 9146441 BACKGROUND

• Kauhanen J, Kaplan GA, Goldberg DD, Cohen RD, Lakka TA, Salonen JT. Frequent hangovers and cardiovascular mortality in middle-aged men. Epidemiology. 1997 May;8(3):310-4. doi: 10.1097/00001648-199705000-00014.

  PMID: 9115028 BACKGROUND

• Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT. Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care. 1997 Mar;20(3):426-8. doi: 10.2337/diacare.20.3.426.

  PMID: 9051399 BACKGROUND

• Lynch JW, Kaplan GA, Salonen JT. Why do poor people behave poorly? Variation in adult health behaviours and psychosocial characteristics by stages of the socioeconomic lifecourse. Soc Sci Med. 1997 Mar;44(6):809-19. doi: 10.1016/s0277-9536(96)00191-8.

  PMID: 9080564 BACKGROUND

• Kauhanen J, Kaplan GA, Cohen RD, Julkunen J, Salonen JT. Alexithymia and risk of death in middle-aged men. J Psychosom Res. 1996 Dec;41(6):541-9. doi: 10.1016/s0022-3999(96)00226-7.

  PMID: 9032717 BACKGROUND

• Lynch J, Kaplan GA, Salonen R, Salonen JT. Socioeconomic status and progression of carotid atherosclerosis. Prospective evidence from the Kuopio Ischemic Heart Disease Risk Factor Study. Arterioscler Thromb Vasc Biol. 1997 Mar;17(3):513-9. doi: 10.1161/01.atv.17.3.513.

  PMID: 9102170 BACKGROUND

• Everson SA, Lynch JW, Chesney MA, Kaplan GA, Goldberg DE, Shade SB, Cohen RD, Salonen R, Salonen JT. Interaction of workplace demands and cardiovascular reactivity in progression of carotid atherosclerosis: population based study. BMJ. 1997 Feb 22;314(7080):553-8. doi: 10.1136/bmj.314.7080.553.

  PMID: 9055713 BACKGROUND

• Rasanen J, Kauhanen J, Lakka TA, Kaplan GA, Salonen JT. Religious affiliation and all-cause mortality: a prospective population study in middle-aged men in eastern Finland. Int J Epidemiol. 1996 Dec;25(6):1244-9. doi: 10.1093/ije/25.6.1244.

  PMID: 9027531 BACKGROUND

• Lynch JW, Kaplan GA, Cohen RD, Tuomilehto J, Salonen JT. Do cardiovascular risk factors explain the relation between socioeconomic status, risk of all-cause mortality, cardiovascular mortality, and acute myocardial infarction? Am J Epidemiol. 1996 Nov 15;144(10):934-42. doi: 10.1093/oxfordjournals.aje.a008863.

  PMID: 8916504 BACKGROUND

• Everson SA, Kaplan GA, Goldberg DE, Salonen JT. Anticipatory blood pressure response to exercise predicts future high blood pressure in middle-aged men. Hypertension. 1996 May;27(5):1059-64. doi: 10.1161/01.hyp.27.5.1059.

  PMID: 8621197 BACKGROUND

• Salonen JT, Nyyssonen K, Tuomainen TP, Maenpaa PH, Korpela H, Kaplan GA, Lynch J, Helmrich SP, Salonen R. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ. 1995 Oct 28;311(7013):1124-7. doi: 10.1136/bmj.311.7013.1124.

  PMID: 7580706 BACKGROUND

• Lynch J, Kaplan GA, Salonen R, Cohen RD, Salonen JT. Socioeconomic status and carotid atherosclerosis. Circulation. 1995 Oct 1;92(7):1786-92. doi: 10.1161/01.cir.92.7.1786.

  PMID: 7671362 BACKGROUND

• Kaplan GA, Wilson TW, Cohen RD, Kauhanen J, Wu M, Salonen JT. Social functioning and overall mortality: prospective evidence from the Kuopio Ischemic Heart Disease Risk Factor Study. Epidemiology. 1994 Sep;5(5):495-500.

  PMID: 7986863 BACKGROUND

• Lynch JW, Kaplan GA, Cohen RD, Kauhanen J, Wilson TW, Smith NL, Salonen JT. Childhood and adult socioeconomic status as predictors of mortality in Finland. Lancet. 1994 Feb 26;343(8896):524-7. doi: 10.1016/s0140-6736(94)91468-0.

  PMID: 7906766 BACKGROUND

• Kauhanen J, Kaplan GA, Cohen RD, Salonen R, Salonen JT. Alexithymia may influence the diagnosis of coronary heart disease. Psychosom Med. 1994 May-Jun;56(3):237-44. doi: 10.1097/00006842-199405000-00010.

  PMID: 8084970 BACKGROUND

• Wilson TW, Kaplan GA, Kauhanen J, Cohen RD, Wu M, Salonen R, Salonen JT. Association between plasma fibrinogen concentration and five socioeconomic indices in the Kuopio Ischemic Heart Disease Risk Factor Study. Am J Epidemiol. 1993 Feb 1;137(3):292-300. doi: 10.1093/oxfordjournals.aje.a116676.

  PMID: 8452137 BACKGROUND

• Kauhanen J, Hallikainen T, Tuomainen TP, Koulu M, Karvonen MK, Salonen JT, Tiihonen J. Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers. Alcohol Clin Exp Res. 2000 Feb;24(2):135-9.

  PMID: 10698363 BACKGROUND

• Everson SA, Kaplan GA, Goldberg DE, Salonen JT. Hypertension incidence is predicted by high levels of hopelessness in Finnish men. Hypertension. 2000 Feb;35(2):561-7. doi: 10.1161/01.hyp.35.2.561.

  PMID: 10679498 BACKGROUND

• Salonen JT, Seppanen K, Lakka TA, Salonen R, Kaplan GA. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis. 2000 Feb;148(2):265-73. doi: 10.1016/s0021-9150(99)00272-5.

  PMID: 10657561 BACKGROUND

• Kaplan GA, Lynch JW. Socioeconomic considerations in the primordial prevention of cardiovascular disease. Prev Med. 1999 Dec;29(6 Pt 2):S30-5. doi: 10.1006/pmed.1999.0540.

  PMID: 10641815 BACKGROUND

• Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H, Salonen JT. Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet. 1999 Dec 18-25;354(9196):2112-5. doi: 10.1016/S0140-6736(99)05031-X.

  PMID: 10609816 BACKGROUND

• Kauhanen J, Kaplan GA, Goldberg DE, Salonen R, Salonen JT. Pattern of alcohol drinking and progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):3001-6. doi: 10.1161/01.atv.19.12.3001.

  PMID: 10591681 BACKGROUND

• Tuomainen TP, Kontula K, Nyyssonen K, Lakka TA, Helio T, Salonen JT. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland. Circulation. 1999 Sep 21;100(12):1274-9. doi: 10.1161/01.cir.100.12.1274.

  PMID: 10491370 BACKGROUND

• Salonen JT, Malin R, Tuomainen TP, Nyyssonen K, Lakka TA, Lehtimaki T. Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study. BMJ. 1999 Aug 21;319(7208):487-9; discussion 490. doi: 10.1136/bmj.319.7208.487. No abstract available.

  PMID: 10454401 BACKGROUND

• Lakka TA, Salonen R, Kaplan GA, Salonen JT. Blood pressure and the progression of carotid atherosclerosis in middle-aged men. Hypertension. 1999 Jul;34(1):51-6. doi: 10.1161/01.hyp.34.1.51.

  PMID: 10406823 BACKGROUND

• Everson SA, Kaplan GA, Goldberg DE, Lakka TA, Sivenius J, Salonen JT. Anger expression and incident stroke: prospective evidence from the Kuopio ischemic heart disease study. Stroke. 1999 Mar;30(3):523-8. doi: 10.1161/01.str.30.3.523.

  PMID: 10066846 BACKGROUND

• Everson SA, Goldberg DE, Kaplan GA, Julkunen J, Salonen JT. Anger expression and incident hypertension. Psychosom Med. 1998 Nov-Dec;60(6):730-5. doi: 10.1097/00006842-199811000-00014.

  PMID: 9847033 BACKGROUND

• Everson SA, Goldberg DE, Helmrich SP, Lakka TA, Lynch JW, Kaplan GA, Salonen JT. Weight gain and the risk of developing insulin resistance syndrome. Diabetes Care. 1998 Oct;21(10):1637-43. doi: 10.2337/diacare.21.10.1637.

  PMID: 9773723 BACKGROUND

• Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K. Relation between iron stores and non-insulin dependent diabetes in men: case-control study. BMJ. 1998 Sep 12;317(7160):727. doi: 10.1136/bmj.317.7160.727. No abstract available.

  PMID: 9732340 BACKGROUND

• Salonen JT. Excessive intake of iron and mercury in cardiovascular disease. Bibl Nutr Dieta. 1998;(54):112-26. doi: 10.1159/000059452. No abstract available.

  PMID: 9597177 BACKGROUND

• Lakka TA, Laukkanen JA, Rauramaa R, Salonen R, Lakka HM, Kaplan GA, Salonen JT. Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med. 2001 Jan 2;134(1):12-20. doi: 10.7326/0003-4819-134-1-200101020-00008.

  PMID: 11187415 BACKGROUND

• Lakka TA, Lakka HM, Salonen R, Kaplan GA, Salonen JT. Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men. Atherosclerosis. 2001 Feb 1;154(2):497-504. doi: 10.1016/s0021-9150(00)00514-1.

  PMID: 11166785 BACKGROUND

• Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT. The common pentanucleotide polymorphism of the 3'-untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in non-diabetic men: a prospective case-control study. J Intern Med. 2000 Jul;248(1):77-83. doi: 10.1046/j.1365-2796.2000.00696.x.

  PMID: 10947884 BACKGROUND

• Krause N, Lynch JW, Kaplan GA, Cohen RD, Salonen R, Salonen JT. Standing at work and progression of carotid atherosclerosis. Scand J Work Environ Health. 2000 Jun;26(3):227-36. doi: 10.5271/sjweh.536.

  PMID: 10901115 BACKGROUND

• Kauhanen J, Karvonen MK, Pesonen U, Koulu M, Tuomainen TP, Uusitupa MI, Salonen JT. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am J Med Genet. 2000 Jul 17;93(2):117-21. doi: 10.1002/1096-8628(20000717)93:23.0.co;2-#.

  PMID: 10869113 BACKGROUND

• Salonen JT, Tuomainen TP, Kontula K. Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: prospective cohort study. BMJ. 2000 Jun 24;320(7251):1706-7. doi: 10.1136/bmj.320.7251.1706. No abstract available.

  PMID: 10864547 BACKGROUND

• Helkala EL, Lakka T, Vanhanen M, Tuomainen TP, Ehnholm C, Kaplan GA, Salonen JT. Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample. Diabet Med. 2001 Dec;18(12):991-7. doi: 10.1046/j.0742-3071.2001.00588.x.

  PMID: 11903399 BACKGROUND

• Turrell G, Lynch JW, Kaplan GA, Everson SA, Helkala EL, Kauhanen J, Salonen JT. Socioeconomic position across the lifecourse and cognitive function in late middle age. J Gerontol B Psychol Sci Soc Sci. 2002 Jan;57(1):S43-51. doi: 10.1093/geronb/57.1.s43.

  PMID: 11773232 BACKGROUND

• Everson SA, Lynch JW, Kaplan GA, Lakka TA, Sivenius J, Salonen JT. Stress-induced blood pressure reactivity and incident stroke in middle-aged men. Stroke. 2001 Jun;32(6):1263-70. doi: 10.1161/01.str.32.6.1263.

  PMID: 11387485 BACKGROUND

• Kaplan GA, Turrell G, Lynch JW, Everson SA, Helkala EL, Salonen JT. Childhood socioeconomic position and cognitive function in adulthood. Int J Epidemiol. 2001 Apr;30(2):256-63. doi: 10.1093/ije/30.2.256.

  PMID: 11369724 BACKGROUND

• Vanharanta M, Voutilainen S, Rissanen TH, Adlercreutz H, Salonen JT. Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med. 2003 May 12;163(9):1099-104. doi: 10.1001/archinte.163.9.1099.

  PMID: 12742810 BACKGROUND

• Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002 Dec 4;288(21):2709-16. doi: 10.1001/jama.288.21.2709.

  PMID: 12460094 BACKGROUND

• Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002 Dec 1;156(11):1070-7. doi: 10.1093/aje/kwf145.

  PMID: 12446265 BACKGROUND

• Lakka HM, Salonen JT, Tuomilehto J, Kaplan GA, Lakka TA. Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men. Horm Metab Res. 2002 Sep;34(9):492-8. doi: 10.1055/s-2002-34788.

  PMID: 12384825 BACKGROUND

• Everson SA, Maty SC, Lynch JW, Kaplan GA. Epidemiologic evidence for the relation between socioeconomic status and depression, obesity, and diabetes. J Psychosom Res. 2002 Oct;53(4):891-5. doi: 10.1016/s0022-3999(02)00303-3.

  PMID: 12377299 BACKGROUND

• Laaksonen DE, Lakka TA, Lakka HM, Nyyssonen K, Rissanen T, Niskanen LK, Salonen JT. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med. 2002 Jun;19(6):456-64. doi: 10.1046/j.1464-5491.2002.00707.x.

  PMID: 12060056 BACKGROUND

• Kurl S, Tuomainen TP, Laukkanen JA, Nyyssonen K, Lakka T, Sivenius J, Salonen JT. Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke. 2002 Jun;33(6):1568-73. doi: 10.1161/01.str.0000017220.78722.d7.

  PMID: 12052992 BACKGROUND

• Harper S, Lynch J, Hsu WL, Everson SA, Hillemeier MM, Raghunathan TE, Salonen JT, Kaplan GA. Life course socioeconomic conditions and adult psychosocial functioning. Int J Epidemiol. 2002 Apr;31(2):395-403.

  PMID: 11980802 BACKGROUND

• Lakka HM, Lakka TA, Tuomilehto J, Salonen JT. Abdominal obesity is associated with increased risk of acute coronary events in men. Eur Heart J. 2002 May;23(9):706-13. doi: 10.1053/euhj.2001.2889.

  PMID: 11977996 BACKGROUND

• Laaksonen DE, Nyyssonen K, Niskanen L, Rissanen TH, Salonen JT. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med. 2005 Jan 24;165(2):193-9. doi: 10.1001/archinte.165.2.193.

  PMID: 15668366 BACKGROUND

• Tolmunen T, Hintikka J, Voutilainen S, Ruusunen A, Alfthan G, Nyyssonen K, Viinamaki H, Kaplan GA, Salonen JT. Association between depressive symptoms and serum concentrations of homocysteine in men: a population study. Am J Clin Nutr. 2004 Dec;80(6):1574-8. doi: 10.1093/ajcn/80.6.1574.

  PMID: 15585771 BACKGROUND

• Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men. Hypertension. 2004 Dec;44(6):820-5. doi: 10.1161/01.HYP.0000148460.95060.f2. Epub 2004 Nov 8.

  PMID: 15534077 BACKGROUND

• Niskanen L, Laaksonen DE, Nyyssonen K, Punnonen K, Valkonen VP, Fuentes R, Tuomainen TP, Salonen R, Salonen JT. Inflammation, abdominal obesity, and smoking as predictors of hypertension. Hypertension. 2004 Dec;44(6):859-65. doi: 10.1161/01.HYP.0000146691.51307.84. Epub 2004 Oct 18.

  PMID: 15492131 BACKGROUND

• Tolmunen T, Hintikka J, Ruusunen A, Voutilainen S, Tanskanen A, Valkonen VP, Viinamaki H, Kaplan GA, Salonen JT. Dietary folate and the risk of depression in Finnish middle-aged men. A prospective follow-up study. Psychother Psychosom. 2004 Nov-Dec;73(6):334-9. doi: 10.1159/000080385.

  PMID: 15479987 BACKGROUND

• Laukkanen JA, Laaksonen DE, Niskanen L, Pukkala E, Hakkarainen A, Salonen JT. Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study. Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1646-50.

  PMID: 15466982 BACKGROUND

• Jennings JR, Kamarck TW, Everson-Rose SA, Kaplan GA, Manuck SB, Salonen JT. Exaggerated blood pressure responses during mental stress are prospectively related to enhanced carotid atherosclerosis in middle-aged Finnish men. Circulation. 2004 Oct 12;110(15):2198-203. doi: 10.1161/01.CIR.0000143840.77061.E9. Epub 2004 Sep 27.

  PMID: 15451789 BACKGROUND

• Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J. 2004 Aug;25(16):1428-37. doi: 10.1016/j.ehj.2004.06.013.

  PMID: 15321701 BACKGROUND

• Laaksonen DE, Niskanen L, Nyyssonen K, Punnonen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. Diabetologia. 2004 Aug;47(8):1403-10. doi: 10.1007/s00125-004-1472-x. Epub 2004 Jul 28.

  PMID: 15309290 BACKGROUND

• Laaksonen DE, Laukkanen JA, Niskanen L, Nyyssonen K, Rissanen TH, Voutilainen S, Pukkala E, Hakkarainen A, Salonen JT. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer. 2004 Sep 1;111(3):444-50. doi: 10.1002/ijc.11614.

  PMID: 15221975 BACKGROUND

• Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004 May;27(5):1036-41. doi: 10.2337/diacare.27.5.1036.

  PMID: 15111517 BACKGROUND

• Fan YM, Salonen JT, Koivu TA, Tuomainen TP, Nyyssonen K, Lakka TA, Salonen R, Seppanen K, Nikkari ST, Tahvanainen E, Lehtimaki T. Hepatic lipase C-480T polymorphism modifies the effect of HDL cholesterol on the risk of acute myocardial infarction in men: a prospective population based study. J Med Genet. 2004 Mar;41(3):e28. doi: 10.1136/jmg.2003.010652. No abstract available.

  PMID: 14985399 BACKGROUND

• Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Salonen R, Rauramaa R, Salonen JT. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003 Dec;149(6):601-8. doi: 10.1530/eje.0.1490601.

  PMID: 14641004 BACKGROUND

• Salonen JT. Liver damage and protective effect of high density lipoprotein cholesterol. BMJ. 2003 Nov 8;327(7423):1082-3. doi: 10.1136/bmj.327.7423.1082.

  PMID: 14604929 BACKGROUND

• Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Cardiorespiratory fitness and the risk for stroke in men. Arch Intern Med. 2003 Jul 28;163(14):1682-8. doi: 10.1001/archinte.163.14.1682.

  PMID: 12885683 BACKGROUND

• Kurl S, Laukkanen JA, Tuomainen TP, Rauramaa R, Lakka TA, Salonen R, Eranen J, Sivenius J, Salonen JT. Association of exercise-induced, silent ST-segment depression with the risk of stroke and cardiovascular diseases in men. Stroke. 2003 Jul;34(7):1760-5. doi: 10.1161/01.STR.0000078564.46376.0A. Epub 2003 Jun 26.

  PMID: 12829872 BACKGROUND

• Krause N, Lynch J, Kaplan GA, Cohen RD, Goldberg DE, Salonen JT. Predictors of disability retirement. Scand J Work Environ Health. 1997 Dec;23(6):403-13. doi: 10.5271/sjweh.262.

  PMID: 9476803 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Carotid Artery Diseases; Arrhythmias, Cardiac; Myocardial Ischemia; Thrombosis; Heart Diseases; Atherosclerosis

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Embolism and Thrombosis; Arteriosclerosis; Arterial Occlusive Diseases

Study Officials

• George Kaplan

  University of Michigan

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: July 1, 1990
• Study Completion: August 1, 2002
• Last Updated: May 13, 2016

Record last verified: 2005-07