NCT00005253

Brief Summary

To determine whether treatment with antidepressant, anticonvulsant, and antiarrhythmic drug therapies having the potential for proarrhythmia increased the risk of primary cardiac arrest. The aim of the original grant, starting in 1990 and ending in 1994, was to determine whether use of diuretics for hypertension increased the risk of primary cardiac arrest compared to the use of other antihypertensive agents.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jan 1990

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1990

Completed
10 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2000

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 10, 2016

Status Verified

January 1, 2006

First QC Date

May 25, 2000

Last Update Submit

February 8, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHeart ArrestHypertensionArrhythmia

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (5)

  • Siscovick DS, Raghunathan TE, Psaty BM, Koepsell TD, Wicklund KG, Lin X, Cobb L, Rautaharju PM, Copass MK, Wagner EH. Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med. 1994 Jun 30;330(26):1852-7. doi: 10.1056/NEJM199406303302603.

    PMID: 8196728BACKGROUND

  • Siscovick DS, Raghunathan TE, Rautaharju P, Psaty BM, Cobb LA, Wagner EH. Clinically silent electrocardiographic abnormalities and risk of primary cardiac arrest among hypertensive patients. Circulation. 1996 Sep 15;94(6):1329-33. doi: 10.1161/01.cir.94.6.1329.

    PMID: 8822988BACKGROUND

  • Siscovick DS, Raghunathan TE, Psaty BM, Koepsell TD, Cobb L, Rautaharju PM, Wagner EH. Diastolic blood pressure and the risk of primary cardiac arrest among pharmacologically treated hypertensive patients. J Gen Intern Med. 1996 Jun;11(6):350-6. doi: 10.1007/BF02600046.

    PMID: 8803741BACKGROUND

  • Rea TD, Siscovick DS, Psaty BM, Pearce RM, Raghunathan TE, Whitsel EA, Cobb LA, Weinmann S, Anderson GD, Arbogast P, Lin D. Digoxin therapy and the risk of primary cardiac arrest in patients with congestive heart failure: effect of mild-moderate renal impairment. J Clin Epidemiol. 2003 Jul;56(7):646-50. doi: 10.1016/s0895-4356(03)00075-1.

    PMID: 12921933BACKGROUND

  • Empana JP, Jouven X, Lemaitre RN, Sotoodehnia N, Rea T, Raghunathan TE, Simon G, Siscovick DS. Clinical depression and risk of out-of-hospital cardiac arrest. Arch Intern Med. 2006 Jan 23;166(2):195-200. doi: 10.1001/archinte.166.2.195.

    PMID: 16432088BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHeart ArrestHypertensionArrhythmias, Cardiac

Condition Hierarchy (Ancestors)

Vascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • David Siscovick

    University of Washington

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

January 1, 1990

Study Completion

January 1, 2000

Last Updated

February 10, 2016

Record last verified: 2006-01