NCT00005238

Brief Summary

To determine the role of environmental stressors in the development of hypertension in Black and white school-age children from hypertensive families.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Dec 1988

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1988

Completed
11.5 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
1.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2001

Completed
Last Updated

December 23, 2015

Status Verified

December 1, 2004

First QC Date

May 25, 2000

Last Update Submit

December 21, 2015

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

Age7 Years - 14 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (46)

  • Murdison KA, Treiber FA, Mensah G, Davis H, Thompson W, Strong WB. Prediction of left ventricular mass in youth with family histories of essential hypertension. Am J Med Sci. 1998 Feb;315(2):118-23. doi: 10.1097/00000441-199802000-00008.

    PMID: 9472911BACKGROUND

  • Treiber FA, Musante L, Strong WB, Levy M. Racial differences in young children's blood pressure. Responses to dynamic exercise. Am J Dis Child. 1989 Jun;143(6):720-3. doi: 10.1001/archpedi.1989.02150180102029.

    PMID: 2729217BACKGROUND

  • Treiber FA, Musante L, Hartdagan S, Davis H, Levy M, Strong WB. Validation of a heart rate monitor with children in laboratory and field settings. Med Sci Sports Exerc. 1989 Jun;21(3):338-42.

    PMID: 2733584BACKGROUND

  • Treiber FA, Musante L, Riley W, Mabe PA, Carr T, Levy M, Strong WB. The relationship between hostility and blood pressure in children. Behav Med. 1989 Winter;15(4):173-8. doi: 10.1080/08964289.1989.9934581.

    PMID: 2597781BACKGROUND

  • Treiber FA, Mabe PA 3rd, Riley W, Carr T, Levy M, Thompson W, Strong WB. Assessment of children's Type A behavior: relationship with negative behavioral characteristics and children and teacher demographic characteristics. J Pers Assess. 1989 Winter;53(4):770-82. doi: 10.1207/s15327752jpa5304_13.

    PMID: 2607405BACKGROUND

  • Treiber FA, Leonard SB, Frank G, Musante L, Davis H, Strong WB, Levy M. Dietary assessment instruments for preschool children: reliability of parental responses to the 24-hour recall and a food frequency questionnaire. J Am Diet Assoc. 1990 Jun;90(6):814-20.

    PMID: 2345254BACKGROUND

  • Braden DS, Leatherbury L, Treiber FA, Strong WB. Noninvasive assessment of cardiac output in children using impedance cardiography. Am Heart J. 1990 Nov;120(5):1166-72. doi: 10.1016/0002-8703(90)90132-h.

    PMID: 2239669BACKGROUND

  • Riley WT, Treiber FA. The validity of multidimensional self-report anger and hostility measures. J Clin Psychol. 1989 May;45(3):397-404. doi: 10.1002/1097-4679(198905)45:33.0.co;2-4.

    PMID: 2745729BACKGROUND

  • Musante L, Treiber FA, Strong WB, Levy M. Family history of hypertension and cardiovascular reactivity to forehead cold stimulation in black male children. J Psychosom Res. 1990;34(1):111-6. doi: 10.1016/0022-3999(90)90014-u.

    PMID: 2313609BACKGROUND

  • Treiber FA, Musante L, Braden D, Arensman F, Strong WB, Levy M, Leverett S. Racial differences in hemodynamic responses to the cold face stimulus in children and adults. Psychosom Med. 1990 May-Jun;52(3):286-96. doi: 10.1097/00006842-199005000-00003.

    PMID: 2367620BACKGROUND

  • Musante L, Treiber FA, Strong WB, Levy M. Individual and cross-spouse correlations of perceptions of family functioning, blood pressure and dimensions of anger. J Psychosom Res. 1990;34(4):393-9. doi: 10.1016/0022-3999(90)90062-9.

    PMID: 2376840BACKGROUND

  • Musante L, Treiber FA, Davis H, Strong WB, Levy M. Hostility: relationship to lifestyle behaviors and physical risk factors. Behav Med. 1992 Spring;18(1):21-6. doi: 10.1080/08964289.1992.10544237.

    PMID: 1591441BACKGROUND

  • Treiber FA, Baranowski T, Braden DS, Strong WB, Levy M, Knox W. Social support for exercise: relationship to physical activity in young adults. Prev Med. 1991 Nov;20(6):737-50. doi: 10.1016/0091-7435(91)90068-f.

    PMID: 1766945BACKGROUND

  • Treiber FA, Strong WB, Arensman FW, Forrest T, Davis H, Musante L. Family history of myocardial infarction and hemodynamic responses to exercise in young black boys. Am J Dis Child. 1991 Sep;145(9):1029-33. doi: 10.1001/archpedi.1991.02160090081029.

    PMID: 1877562BACKGROUND

  • Braden DS, Strong WB. Cardiovascular responses to exercise in childhood. Am J Dis Child. 1990 Nov;144(11):1255-60. doi: 10.1001/archpedi.1990.02150350087033. No abstract available.

    PMID: 2239868BACKGROUND

  • Musante L, Treiber FA, Davis H, Levy M, Strong WB. Temporal stability of children's cardiovascular (CV) reactivity: role of ethnicity, gender and family history of myocardial infarction. Int J Psychophysiol. 1995 Apr;19(3):281-6. doi: 10.1016/0167-8760(95)00011-g.

    PMID: 7558994BACKGROUND

  • Treiber FA, Murphy JK, Davis H, Raunikar RA, Pflieger K, Strong WB. Pressor reactivity, ethnicity, and 24-hour ambulatory monitoring in children from hypertensive families. Behav Med. 1994 Fall;20(3):133-42. doi: 10.1080/08964289.1994.9934628.

    PMID: 7865933BACKGROUND

  • Musante L, Raunikar RA, Treiber F, Davis H, Dysart J, Levy M, Strong WB. Consistency of children's hemodynamic responses to laboratory stressors. Int J Psychophysiol. 1994 Jun;17(1):65-71. doi: 10.1016/0167-8760(94)90056-6.

    PMID: 7961055BACKGROUND

  • Islam S, Gutin B, Manos T, Smith C, Treiber F. Low density lipoprotein cholesterol/apolipoprotein B-100 ratio: interaction of family history of premature atherosclerotic coronary artery disease with race and gender in 7 to 11 year olds. Pediatrics. 1994 Oct;94(4 Pt 1):494-9.

    PMID: 7936858BACKGROUND

  • Islam S, Gutin B, Smith C, Treiber F, Kamboh MI. Association of apolipoprotein(a) phenotypes in children with family history of premature coronary artery disease. Arterioscler Thromb. 1994 Oct;14(10):1609-16. doi: 10.1161/01.atv.14.10.1609.

    PMID: 7918311BACKGROUND

  • Pflieger KL, Treiber FA, Davis H, McCaffrey FM, Raunikar RA, Strong WB. The effect of adiposity on children's left ventricular mass and geometry and haemodynamic responses to stress. Int J Obes Relat Metab Disord. 1994 Feb;18(2):117-22.

    PMID: 8148925BACKGROUND

  • Dysart JM, Treiber FA, Pflieger K, Davis H, Strong WB. Ethnic differences in the myocardial and vascular reactivity to stress in normotensive girls. Am J Hypertens. 1994 Jan;7(1):15-22. doi: 10.1093/ajh/7.1.15.

    PMID: 8136106BACKGROUND

  • Wright LB, Treiber FA, Davis H, Strong WB, Levy M, Van Huss E, Batchelor C. Relationship between family environment and children's hemodynamic responses to stress: a longitudinal evaluation. Behav Med. 1993 Fall;19(3):115-21. doi: 10.1080/08964289.1993.9935180.

    PMID: 8292835BACKGROUND

  • Trieber FA, McCaffrey F, Pflieger K, Raunikar RA, Strong WB, Davis H. Determinants of left ventricular mass in normotensive children. Am J Hypertens. 1993 Jun;6(6 Pt 1):505-13. doi: 10.1093/ajh/6.6.505.

    PMID: 8343234BACKGROUND

  • Treiber FA, Davis H, Musante L, Raunikar RA, Strong WB, McCaffrey F, Meeks MC, Vandernoord R. Ethnicity, gender, family history of myocardial infarction, and hemodynamic responses to laboratory stressors in children. Health Psychol. 1993 Jan;12(1):6-15. doi: 10.1037//0278-6133.12.1.6.

    PMID: 8462501BACKGROUND

  • Treiber FA, McCaffrey F, Musante L, Rhodes T, Davis H, Strong WB, Levy M. Ethnicity, family history of hypertension and patterns of hemodynamic reactivity in boys. Psychosom Med. 1993 Jan-Feb;55(1):70-7. doi: 10.1097/00006842-199301000-00012.

    PMID: 8446745BACKGROUND

  • Musante L, Turner JR, Treiber FA, Davis H, Strong WB. Moderators of ethnic differences in vasoconstrictive reactivity in youth. Ethn Dis. 1996 Autumn;6(3-4):224-34.

    PMID: 9086312BACKGROUND

  • Barnes VA, Treiber FA, Musante L, Turner JR, Davis H, Strong WB. Ethnicity and socioeconomic status: impact on cardiovascular activity at rest and during stress in youth with a family history of hypertension. Ethn Dis. 2000 Winter;10(1):4-16.

    PMID: 10764125BACKGROUND

  • Treiber FA, Jackson RW, Davis H, Pollock JS, Kapuku G, Mensah GA, Pollock DM. Racial differences in endothelin-1 at rest and in response to acute stress in adolescent males. Hypertension. 2000 Mar;35(3):722-5. doi: 10.1161/01.hyp.35.3.722.

    PMID: 10720585BACKGROUND

  • Treiber F, Harshfield G, Davis H, Kapuku G, Moore D. Stress responsivity and body fatness: links between socioeconomic status and cardiovascular risk factors in youth. Ann N Y Acad Sci. 1999;896:435-8. doi: 10.1111/j.1749-6632.1999.tb08163.x. No abstract available.

    PMID: 10681944BACKGROUND

  • Kapuku GK, Treiber FA, Davis HC, Harshfield GA, Cook BB, Mensah GA. Hemodynamic function at rest, during acute stress, and in the field: predictors of cardiac structure and function 2 years later in youth. Hypertension. 1999 Nov;34(5):1026-31. doi: 10.1161/01.hyp.34.5.1026.

    PMID: 10567177BACKGROUND

  • Harshfield GA, Treiber FA, Davis H, Johnson M, Slavens GA, Thompson W. Temporal stability of ambulatory blood pressure and heart rate in youths. Blood Press Monit. 1999 Apr;4(2):87-90.

    PMID: 10450118BACKGROUND

  • Wright LB, Treiber F, Davis H, Bunch C, Strong WB. The role of maternal hostility and family environment upon cardiovascular functioning among youth two years later: socioeconomic and ethnic differences. Ethn Dis. 1998 Autumn;8(3):367-76.

    PMID: 9926907BACKGROUND

  • Barnes VA, Treiber FA, Davis H, Kelley TR, Strong WB. Central adiposity and hemodynamic functioning at rest and during stress in adolescents. Int J Obes Relat Metab Disord. 1998 Nov;22(11):1079-83. doi: 10.1038/sj.ijo.0800730.

    PMID: 9822945BACKGROUND

  • Treiber F, Papavassiliou D, Gutin B, Malpass D, Yi W, Islam S, Davis H, Strong W. Determinants of endothelium-dependent femoral artery vasodilation in youth. Psychosom Med. 1997 Jul-Aug;59(4):376-81. doi: 10.1097/00006842-199707000-00007.

    PMID: 9251157BACKGROUND

  • Musante L, Treiber FA. The relationship between anger-coping styles and lifestyle behaviors in teenagers. J Adolesc Health. 2000 Jul;27(1):63-8. doi: 10.1016/s1054-139x(99)00098-1.

    PMID: 10867354BACKGROUND

  • Musante L, Treiber FA, Kapuku G, Moore D, Davis H, Strong WB. The effects of life events on cardiovascular reactivity to behavioral stressors as a function of socioeconomic status, ethnicity, and sex. Psychosom Med. 2000 Nov-Dec;62(6):760-7. doi: 10.1097/00006842-200011000-00004.

    PMID: 11138994BACKGROUND

  • Harshfield GA, Treiber FA, Wilson ME, Kapuku GK, Davis HC. A longitudinal study of ethnic differences in ambulatory blood pressure patterns in youth. Am J Hypertens. 2002 Jun;15(6):525-30. doi: 10.1016/s0895-7061(02)02267-7.

    PMID: 12074354BACKGROUND

  • Dekkers JC, Snieder H, Van Den Oord EJ, Treiber FA. Moderators of blood pressure development from childhood to adulthood: a 10-year longitudinal study. J Pediatr. 2002 Dec;141(6):770-9. doi: 10.1067/mpd.2002.128113.

    PMID: 12461492BACKGROUND

  • Davis CL, Kapuku G, Snieder H, Kumar M, Treiber FA. Insulin resistance syndrome and left ventricular mass in healthy young people. Am J Med Sci. 2002 Aug;324(2):72-5. doi: 10.1097/00000441-200208000-00005.

    PMID: 12186110BACKGROUND

  • Barbeau P, Kulharya A, Harshfield G, Snieder H, Davis H, Treiber F. Association between angiotensin II type I receptor polymorphism and resting hemodynamics in black and white youth. Ethn Dis. 2002 Winter;12(1):S1-68-71.

    PMID: 11913624BACKGROUND

  • Dekkers JC, Treiber FA, Kapuku G, Snieder H. Differential influence of family history of hypertension and premature myocardial infarction on systolic blood pressure and left ventricular mass trajectories in youth. Pediatrics. 2003 Jun;111(6 Pt 1):1387-93. doi: 10.1542/peds.111.6.1387.

    PMID: 12777557BACKGROUND

  • Kapuku GL, Treiber FA, Davis HC. Relationships among socioeconomic status, stress induced changes in cortisol, and blood pressure in African American males. Ann Behav Med. 2002 Fall;24(4):320-5. doi: 10.1207/S15324796ABM2404_08.

    PMID: 12434943BACKGROUND

  • Moore DB, Howell PB, Treiber FA. Adiposity changes in youth with a family history of cardiovascular disease: impact of ethnicity, gender and socioeconomic status. J Assoc Acad Minor Phys. 2002 Jul;13(3):76-83.

    PMID: 12362564BACKGROUND

  • Treiber FA, Kapuku GK, Davis H, Pollock JS, Pollock DM. Plasma endothelin-1 release during acute stress: role of ethnicity and sex. Psychosom Med. 2002 Sep-Oct;64(5):707-13. doi: 10.1097/01.psy.0000021952.59258.1c.

    PMID: 12271101BACKGROUND

  • Dekkers JC, Podolsky RH, Treiber FA, Barbeau P, Gutin B, Snieder H. Development of general and central obesity from childhood into early adulthood in African American and European American males and females with a family history of cardiovascular disease. Am J Clin Nutr. 2004 Apr;79(4):661-8. doi: 10.1093/ajcn/79.4.661.

    PMID: 15051612BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

  • Frank Treiber

    Augusta University

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

December 1, 1988

Study Completion

December 1, 2001

Last Updated

December 23, 2015

Record last verified: 2004-12