NCT00005243

Brief Summary

To investigate factors which trigger the discharge of implantable cardioverter-defibrillators (ICDs).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Apr 1989

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1989

Completed
11.2 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
4.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2004

Completed
Last Updated

March 16, 2016

Status Verified

December 1, 2005

First QC Date

May 25, 2000

Last Update Submit

March 15, 2016

Conditions

Myocardial InfarctionCardiovascular DiseasesArrhythmiaHeart Diseases

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (31)

  • Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991 Jan 15;133(2):144-53. doi: 10.1093/oxfordjournals.aje.a115853.

    PMID: 1985444BACKGROUND

  • Maclure M. Multivariate refutation of aetiological hypotheses in non-experimental epidemiology. Int J Epidemiol. 1990 Dec;19(4):782-7. doi: 10.1093/ije/19.4.782.

    PMID: 2084003BACKGROUND

  • Mittleman MA. Estimation of exposure prevalence in a population at risk using data from cases and an external estimate of the relative risk. Epidemiology. 1995 Sep;6(5):551-3. doi: 10.1097/00001648-199509000-00016.

    PMID: 8562635BACKGROUND

  • Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE. Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation. 1995 Oct 1;92(7):1720-5. doi: 10.1161/01.cir.92.7.1720.

    PMID: 7671353BACKGROUND

  • Mittleman MA, Maclure M, Robins JM. Control sampling strategies for case-crossover studies: an assessment of relative efficiency. Am J Epidemiol. 1995 Jul 1;142(1):91-8. doi: 10.1093/oxfordjournals.aje.a117550.

    PMID: 7785679BACKGROUND

  • Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators. N Engl J Med. 1993 Dec 2;329(23):1677-83. doi: 10.1056/NEJM199312023292301.

    PMID: 8232456BACKGROUND

  • Verrier RL, Mittelman MA. Cardiovascular consequences of anger and other stress states. Baillieres Clin Neurol. 1997 Jul;6(2):245-59.

    PMID: 9483291BACKGROUND

  • Mittleman MA, Maclure M, Nachnani M, Sherwood JB, Muller JE. Educational attainment, anger, and the risk of triggering myocardial infarction onset. The Determinants of Myocardial Infarction Onset Study Investigators. Arch Intern Med. 1997 Apr 14;157(7):769-75.

    PMID: 9125009BACKGROUND

  • Verrier RL, Muller JE, Hobson JA. Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart. Cardiovasc Res. 1996 Feb;31(2):181-211. No abstract available.

    PMID: 8730394BACKGROUND

  • Verrier RL, Mittleman MA. Life-threatening cardiovascular consequences of anger in patients with coronary heart disease. Cardiol Clin. 1996 May;14(2):289-307. doi: 10.1016/s0733-8651(05)70281-2.

    PMID: 8724560BACKGROUND

  • Mittleman MA, Siscovick DS. Physical exertion as a trigger of myocardial infarction and sudden cardiac death. Cardiol Clin. 1996 May;14(2):263-70. doi: 10.1016/s0733-8651(05)70279-4.

    PMID: 8724558BACKGROUND

  • Muller JE, Mittleman MA, Maclure M, Sherwood JB, Tofler GH. Triggering myocardial infarction by sexual activity. Low absolute risk and prevention by regular physical exertion. Determinants of Myocardial Infarction Onset Study Investigators. JAMA. 1996 May 8;275(18):1405-9. doi: 10.1001/jama.275.18.1405.

    PMID: 8618365BACKGROUND

  • Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Lack of effect of recent alcohol consumption on the course of acute myocardial infarction. Am Heart J. 1999 Nov;138(5 Pt 1):926-33. doi: 10.1016/s0002-8703(99)70019-0.

    PMID: 10539825BACKGROUND

  • Mittleman MA, Mintzer D, Maclure M, Tofler GH, Sherwood JB, Muller JE. Triggering of myocardial infarction by cocaine. Circulation. 1999 Jun 1;99(21):2737-41. doi: 10.1161/01.cir.99.21.2737.

    PMID: 10351966BACKGROUND

  • Mukamal KJ, Mittleman MA, Maclure M, Sherwood JB, Goldberg RJ, Muller JE. Recent aspirin use is associated with smaller myocardial infarct size and lower likelihood of Q-wave infarction. Am Heart J. 1999 Jun;137(6):1120-8. doi: 10.1016/s0002-8703(99)70372-8.

    PMID: 10347341BACKGROUND

  • Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Increased risk of congestive heart failure among infarctions with nighttime onset. Am Heart J. 2000 Sep;140(3):438-42. doi: 10.1067/mhj.2000.108830.

    PMID: 10966545BACKGROUND

  • Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Prior alcohol consumption and mortality following acute myocardial infarction. JAMA. 2001 Apr 18;285(15):1965-70. doi: 10.1001/jama.285.15.1965.

    PMID: 11308432BACKGROUND

  • Mukamal KJ, Nesto RW, Cohen MC, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction. Diabetes Care. 2001 Aug;24(8):1422-7. doi: 10.2337/diacare.24.8.1422.

    PMID: 11473080BACKGROUND

  • Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. Triggering myocardial infarction by marijuana. Circulation. 2001 Jun 12;103(23):2805-9. doi: 10.1161/01.cir.103.23.2805.

    PMID: 11401936BACKGROUND

  • Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Evaluation of sex-related differences in survival after hospitalization for acute myocardial infarction. Am J Cardiol. 2001 Oct 1;88(7):768-71. doi: 10.1016/s0002-9149(01)01848-3. No abstract available.

    PMID: 11589845BACKGROUND

  • Mukamal KJ, Maclure M, Sherwood JB, Kannam JP, Muller JE, Mittleman MA. Height is not associated with long-term survival after acute myocardial infarction. Am Heart J. 2001 Nov;142(5):852-6. doi: 10.1067/mhj.2001.119131.

    PMID: 11685174BACKGROUND

  • Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Tea consumption and mortality after acute myocardial infarction. Circulation. 2002 May 28;105(21):2476-81. doi: 10.1161/01.cir.0000017201.88994.f7.

    PMID: 12034652BACKGROUND

  • Mukamal KJ, Muller JE, Maclure M, Sherwood JB, Mittleman MA. Variation in the risk of onset of acute myocardial infarction during the menstrual cycle. Am J Cardiol. 2002 Jul 1;90(1):49-51. doi: 10.1016/s0002-9149(02)02386-x. No abstract available.

    PMID: 12088780BACKGROUND

  • Mukamal KJ, Muller JE, Walkoff DS, Maclure M, Sherwood JB, Mittleman MA. Comparison of courses of patients with acute myocardial infarction with chest pain appearing during exertion versus those with chest pain not occurring during exertion. Am J Cardiol. 2002 Sep 15;90(6):642-5. doi: 10.1016/s0002-9149(02)02573-0. No abstract available.

    PMID: 12231095BACKGROUND

  • Rana JS, Mukamal KJ, Morgan JP, Muller JE, Mittleman MA. Circadian variation in the onset of myocardial infarction: effect of duration of diabetes. Diabetes. 2003 Jun;52(6):1464-8. doi: 10.2337/diabetes.52.6.1464.

    PMID: 12765958BACKGROUND

  • Whang W, Mittleman MA, Rich DQ, Wang PJ, Ruskin JN, Tofler GH, Muller JE, Albert CM; TOVA Investigators. Heart failure and the risk of shocks in patients with implantable cardioverter defibrillators: results from the Triggers Of Ventricular Arrhythmias (TOVA) study. Circulation. 2004 Mar 23;109(11):1386-91. doi: 10.1161/01.CIR.0000120703.99433.1E. Epub 2004 Mar 1.

    PMID: 14993132BACKGROUND

  • Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Caffeinated coffee consumption and mortality after acute myocardial infarction. Am Heart J. 2004 Jun;147(6):999-1004. doi: 10.1016/j.ahj.2003.12.038.

    PMID: 15199347BACKGROUND

  • Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Educational attainment and myocardial infarct-related congestive heart failure (the Determinants of Myocardial Infarction Onset Study). Am J Cardiol. 2004 May 15;93(10):1288-91. doi: 10.1016/j.amjcard.2004.02.017.

    PMID: 15135707BACKGROUND

  • Rana JS, Mukamal KJ, Morgan JP, Muller JE, Mittleman MA. Obesity and the risk of death after acute myocardial infarction. Am Heart J. 2004 May;147(5):841-6. doi: 10.1016/j.ahj.2003.12.015.

    PMID: 15131540BACKGROUND

  • Whang W, Albert CM, Sears SF Jr, Lampert R, Conti JB, Wang PJ, Singh JP, Ruskin JN, Muller JE, Mittleman MA; TOVA Study Investigators. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) study. J Am Coll Cardiol. 2005 Apr 5;45(7):1090-5. doi: 10.1016/j.jacc.2004.12.053.

    PMID: 15808769BACKGROUND

  • Mukamal KJ, Maclure M, Muller JE, Mittleman MA. Binge drinking and mortality after acute myocardial infarction. Circulation. 2005 Dec 20;112(25):3839-45. doi: 10.1161/CIRCULATIONAHA.105.574749.

    PMID: 16365208BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesArrhythmias, CardiacMyocardial InfarctionHeart Diseases

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and SymptomsMyocardial IschemiaVascular DiseasesInfarctionIschemiaNecrosis

Study Officials

  • James Muller

    Massachusetts General Hospital

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

April 1, 1989

Study Completion

August 1, 2004

Last Updated

March 16, 2016

Record last verified: 2005-12