Lifestyle and Chronic Disease in College Alumni (Harvard Alumni Health Study)

NCT00005169 | Completed

• 1 other identifier: 1043
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To monitor the relationship of lifestyle variables, particularly exercise, to cardiovascular mortality, all-cause mortality, projected longevity and aging, and cardiovascular morbidity in a large cohort of college graduates. To assess changing patterns of exercise, cigarette smoking, body weight, and blood pressure between the 1960s and 1990s for relationship to cardiovascular morbidity and mortality.

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Hypertension; Cerebrovascular Accident

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (46)

• Paffenbarger RS Jr, Wing AL, Hyde RT, Jung DL. Physical activity and incidence of hypertension in college alumni. Am J Epidemiol. 1983 Mar;117(3):245-57. doi: 10.1093/oxfordjournals.aje.a113537.

  PMID: 6829553 BACKGROUND

• Whittemore AS, Paffenbarger RS Jr, Anderson K, Halpern J. Early precursors of pancreatic cancer in college men. J Chronic Dis. 1983;36(3):251-6. doi: 10.1016/0021-9681(83)90059-0.

  PMID: 6826689 BACKGROUND

• Paffenbarger RS Jr: Exercise in the Primary Prevention of Coronary Heart Disease. In: Heart Disease and Rehabilitation, M Pollock (Ed). New York: John Wiley & Sons, 2nd Ed., 1986.

  BACKGROUND

• Paffenbarger RS Jr, Hyde RT. Exercise in the prevention of coronary heart disease. Prev Med. 1984 Jan;13(1):3-22. doi: 10.1016/0091-7435(84)90037-9.

  PMID: 6371776 BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Wing AL, Steinmetz CH. A natural history of athleticism and cardiovascular health. JAMA. 1984 Jul 27;252(4):491-5.

  PMID: 6737639 BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Jung DL, Wing AL. Epidemiology of exercise and coronary heart disease. Clin Sports Med. 1984 Apr;3(2):297-318.

  PMID: 6388854 BACKGROUND

• Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JE. Early precursors of urogenital cancers in former college men. J Urol. 1984 Dec;132(6):1256-61. doi: 10.1016/s0022-5347(17)50118-4.

  PMID: 6502830 BACKGROUND

• Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JE. Early precursors of site-specific cancers in college men and women. J Natl Cancer Inst. 1985 Jan;74(1):43-51.

  PMID: 3855486 BACKGROUND

• Paffenbarger RS Jr: Physical Activity as a Defense Against Coronary Heart Disease. In: Coronary Heart Disease, WE Connor and JD Bristow (Eds). Philadelphia: JB Lippincott Company, 1985

  BACKGROUND

• Powell KE, Paffenbarger RS Jr. Workshop on Epidemiologic and Public Health Aspects of Physical Activity and Exercise: a summary. Public Health Rep. 1985 Mar-Apr;100(2):118-26.

  PMID: 3920710 BACKGROUND

• Paffenbarger RS Jr, Hyde RT: Exercise in the Primary Prevention of Ischemic Heart Disease. In: Current Therapy in Sports Medicine 1985-1986, RP Welsh and RJ Shephard (Eds.), St. Louis: CV Mosby Company, 1985

  BACKGROUND

• Spaulding RB (Ed), Paffenbarger RS Jr, Cooper KH, Fielding JE: Dialogue III - Health Promotion/Disease Prevention. Harvard Public Health Alumni Bulletin, p. 4-40, Spring 1985

  BACKGROUND

• Sasco AJ, Paffenbarger RS Jr. Measles infection and Parkinson's disease. Am J Epidemiol. 1985 Dec;122(6):1017-31. doi: 10.1093/oxfordjournals.aje.a114183.

  PMID: 4061437 BACKGROUND

• Curfman GD, Thomas GS, Paffenbarger RS Jr: Physical Activity and Primary Prevention of Cardiovascular Disease. In: Cardiovascular Clinics (Symposium on Preventive Cardiology and Cardiac Rehabilitation), GD Curfman, A Leaf (Eds). Volume 3, Number 2:203-222. Philadelphia, WB Saunders Company, May 1985

  BACKGROUND

• Whittemore AS, Zheng S, Wu A, Wu ML, Fingar T, Jiao DA, Ling CD, Bao JL, Henderson BE, Paffenbarger RS Jr. Colorectal cancer in Chinese and Chinese-Americans. Natl Cancer Inst Monogr. 1985 Dec;69:43-6.

  PMID: 3834343 BACKGROUND

• Blair SN, Haskell WL, Ho P, Paffenbarger RS Jr, Vranizan KM, Farquhar JW, Wood PD. Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am J Epidemiol. 1985 Nov;122(5):794-804. doi: 10.1093/oxfordjournals.aje.a114163.

  PMID: 3876763 BACKGROUND

• Paffenbarger RS Jr: Exercise in the Primary Prevention of Coronary Heart Disease. In: Heart Disease and Rehabilitation, M Pollock and DH Schmidt (Eds). New York: John Wiley & Sons, 2nd Ed., p. 349-367, 1986

  BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986 Mar 6;314(10):605-13. doi: 10.1056/NEJM198603063141003.

  PMID: 3945246 BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Hsieh CC, Wing AL. Physical activity, other life-style patterns, cardiovascular disease and longevity. Acta Med Scand Suppl. 1986;711:85-91. doi: 10.1111/j.0954-6820.1986.tb08936.x.

  PMID: 3535417 BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh C. Cigarette smoking and cardiovascular diseases. IARC Sci Publ. 1986;(74):45-60.

  PMID: 3305337 BACKGROUND

• Paffenbarger RS Jr. Contributions of epidemiology to exercise science and cardiovascular health. Med Sci Sports Exerc. 1988 Oct;20(5):426-38.

  PMID: 3057307 BACKGROUND

• Kohl HW 3rd, Powell KE, Gordon NF, Blair SN, Paffenbarger RS Jr. Physical activity, physical fitness, and sudden cardiac death. Epidemiol Rev. 1992;14:37-58. doi: 10.1093/oxfordjournals.epirev.a036091. No abstract available.

  PMID: 1289116 BACKGROUND

• Paffenbarger RS Jr, Lee IM, Wing AL. The influence of physical activity on the incidence of site-specific cancers in college alumni. Adv Exp Med Biol. 1992;322:7-15. doi: 10.1007/978-1-4684-7953-9_2. No abstract available.

  PMID: 1442302 BACKGROUND

• Lee IM, Paffenbarger RS Jr, Hsieh CC. Time trends in physical activity among college alumni, 1962-1988. Am J Epidemiol. 1992 Apr 15;135(8):915-25. doi: 10.1093/oxfordjournals.aje.a116387.

  PMID: 1585904 BACKGROUND

• Hsieh CC, Maisonneuve P, Boyle P, Macfarlane GJ, Roberston C. Analysis of quantitative data by quantiles in epidemiologic studies: classification according to cases, noncases, or all subjects? Epidemiology. 1991 Mar;2(2):137-40. doi: 10.1097/00001648-199103000-00008.

  PMID: 1932311 BACKGROUND

• Paffenbarger RS Jr, Jung DL, Leung RW, Hyde RT. Physical activity and hypertension: an epidemiological view. Ann Med. 1991 Aug;23(3):319-27. doi: 10.3109/07853899109148067.

  PMID: 1930924 BACKGROUND

• Hsieh CC. The effect of non-differential outcome misclassification on estimates of the attributable and prevented fraction. Stat Med. 1991 Mar;10(3):361-73. doi: 10.1002/sim.4780100308.

  PMID: 2028120 BACKGROUND

• Paffenbarger RS Jr, Kampert JB, Lee IM, Hyde RT, Leung RW, Wing AL. Changes in physical activity and other lifeway patterns influencing longevity. Med Sci Sports Exerc. 1994 Jul;26(7):857-65.

  PMID: 7934759 BACKGROUND

• Lee IM, Manson JE, Hennekens CH, Paffenbarger RS Jr. Body weight and mortality. A 27-year follow-up of middle-aged men. JAMA. 1993 Dec 15;270(23):2823-8. doi: 10.1001/jama.270.23.2823.

  PMID: 8133621 BACKGROUND

• Paffenbarger RS Jr, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med. 1993 Feb 25;328(8):538-45. doi: 10.1056/NEJM199302253280804.

  PMID: 8426621 BACKGROUND

• Paffenbarger RS Jr, Blair SN, Lee IM, Hyde RT. Measurement of physical activity to assess health effects in free-living populations. Med Sci Sports Exerc. 1993 Jan;25(1):60-70. doi: 10.1249/00005768-199301000-00010.

  PMID: 8423758 BACKGROUND

• Helmrich SP, Ragland DR, Paffenbarger RS Jr. Prevention of non-insulin-dependent diabetes mellitus with physical activity. Med Sci Sports Exerc. 1994 Jul;26(7):824-30.

  PMID: 7934754 BACKGROUND

• Paffenbarger RS Jr, Lee IM, Leung R. Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatr Scand Suppl. 1994;377:16-22. doi: 10.1111/j.1600-0447.1994.tb05796.x.

  PMID: 8053361 BACKGROUND

• Lee IM, Paffenbarger RS Jr. Do physical activity and physical fitness avert premature mortality? Exerc Sport Sci Rev. 1996;24:135-71. No abstract available.

  PMID: 8744249 BACKGROUND

• Paffenbarger RS Jr, Kampert JB, Lee IM. Physical activity and health of college men: longitudinal observations. Int J Sports Med. 1997 Jul;18 Suppl 3:S200-3. doi: 10.1055/s-2007-972715.

  PMID: 9272849 BACKGROUND

• Paffenbarger RS Jr, Lee IM, Kampert JB. Physical activity in the prevention of non-insulin-dependent diabetes mellitus. World Rev Nutr Diet. 1997;82:210-8. doi: 10.1159/000059640. No abstract available.

  PMID: 9270323 BACKGROUND

• Sahi T, Paffenbarger RS Jr, Hsieh CC, Lee IM. Body mass index, cigarette smoking, and other characteristics as predictors of self-reported, physician-diagnosed gallbladder disease in male college alumni. Am J Epidemiol. 1998 Apr 1;147(7):644-51. doi: 10.1093/oxfordjournals.aje.a009505.

  PMID: 9554603 BACKGROUND

• Lee IM, Paffenbarger RS Jr. Associations of light, moderate, and vigorous intensity physical activity with longevity. The Harvard Alumni Health Study. Am J Epidemiol. 2000 Feb 1;151(3):293-9. doi: 10.1093/oxfordjournals.aje.a010205.

  PMID: 10670554 BACKGROUND

• Cole SR, Kawachi I, Sesso HD, Paffenbarger RS, Lee IM. Sense of exhaustion and coronary heart disease among college alumni. Am J Cardiol. 1999 Dec 15;84(12):1401-5. doi: 10.1016/s0002-9149(99)00585-8.

  PMID: 10606112 BACKGROUND

• Sesso HD, Paffenbarger RS, Ha T, Lee IM. Physical activity and cardiovascular disease risk in middle-aged and older women. Am J Epidemiol. 1999 Aug 15;150(4):408-16. doi: 10.1093/oxfordjournals.aje.a010020.

  PMID: 10453817 BACKGROUND

• Lee IM, Paffenbarger RS Jr. Life is sweet: candy consumption and longevity. BMJ. 1998 Dec 19-26;317(7174):1683-4. doi: 10.1136/bmj.317.7174.1683. No abstract available.

  PMID: 9857124 BACKGROUND

• Lee IM, Paffenbarger RS Jr. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke. 1998 Oct;29(10):2049-54. doi: 10.1161/01.str.29.10.2049.

  PMID: 9756580 BACKGROUND

• Lee IM, Sesso HD, Paffenbarger RS Jr. Physical activity and coronary heart disease risk in men: does the duration of exercise episodes predict risk? Circulation. 2000 Aug 29;102(9):981-6. doi: 10.1161/01.cir.102.9.981.

  PMID: 10961961 BACKGROUND

• Sesso HD, Paffenbarger RS Jr, Lee IM. Physical activity and coronary heart disease in men: The Harvard Alumni Health Study. Circulation. 2000 Aug 29;102(9):975-80. doi: 10.1161/01.cir.102.9.975.

  PMID: 10961960 BACKGROUND

• Sesso HD, Paffenbarger RS Jr, Lee IM. Alcohol consumption and risk of prostate cancer: The Harvard Alumni Health Study. Int J Epidemiol. 2001 Aug;30(4):749-55. doi: 10.1093/ije/30.4.749.

  PMID: 11511598 BACKGROUND

• Sesso HD, Paffenbarger RS, Lee IM. Comparison of National Death Index and World Wide Web death searches. Am J Epidemiol. 2000 Jul 15;152(2):107-11. doi: 10.1093/aje/152.2.107.

  PMID: 10909946 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Disease; Hypertension; Stroke

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Ralph Paffenbarger

  Stanford University

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: September 1, 1984
• Study Completion: June 1, 2000
• Last Updated: June 24, 2005

Record last verified: 2002-10