Observing Patients With Early HIV Infection

NCT00005020 | Completed

• 2 other identifiers: AIEDRP AI-05-008AEHIV 008
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to monitor patients who have recently been infected with HIV in order to learn how their immune systems respond to HIV infection and to study how the virus multiplies in their bodies. Patients who have been infected with HIV recently are considered to have acute, or early, HIV infection. During this period, viral load (level of HIV in the body) rises sharply to a high level at first but then decreases significantly on its own. Doctors are not sure why this decrease in viral load happens and how the body is able to accomplish this. In this study, patients with acute HIV infection will be monitored so that doctors can study their immune systems to try to learn more about this rise and fall in viral load.

Conditions

HIV Infections

Keywords

CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Phenotype; Viral Load; Acute Infection

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Volunteers may be eligible for Cohort I of this study if they:
• Are at least 13 years old (consent of parent or guardian required if under 18).
• Have no active infections or cancer.
• Are HIV-negative.
• Volunteers may be eligible for Cohort II of this study if they:
• Are at least 13 years old (consent of parent or guardian required if under 18).
• Have acute or early HIV infection. The stage of HIV infection will depend on the results of certain lab tests.
• Agree not to take anti-HIV drugs the first 4 weeks of the study.

You may not qualify if:

• Volunteers will not be eligible for this study if they:
• Weigh less than 45 kg (99 pounds).
• Have begun anti-HIV therapy.
• Are pregnant or breast-feeding.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

Joanne Santangelo

San Diego, California, 92103, United States

Location

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Susan Little

  PRINCIPAL INVESTIGATOR

• Diane Havlir

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: April 6, 2000
• First Posted: August 31, 2001
• Last Updated: March 25, 2010

Record last verified: 2004-12

Locations

US (1)