Electromyography to Diagnose Neuromuscular Disorders
Diagnosis of Neuromuscular Disorders With Specialized Electromyographic Studies
2 other identifiers
interventional
30
1 country
1
Brief Summary
This study will investigate problems with muscle weakness and control using electromyography-a test of nerve-muscle cell communication. Advanced techniques called single fiber electromyography and macro-electromyography, which evaluate individual muscle fibers, will be used. Besides aiding in diagnosis, these tests provide information about disease progression that may be useful in guiding therapy. Adult patients with suspected neurological disorders of muscle control and weakness may be eligible for this study. Normal volunteers may also participate. For the electromyography procedure, a special needle is inserted into a muscle. The patient will slightly tense the muscle and maintain the tension while electrical signals from the muscle fibers are being recorded. The electrical signals are played through a loudspeaker, providing feedback to help the patient tense the muscle the appropriate amount. The test, which is usually done for only one muscle, takes 1 to 2 hours. If needed, short breaks can be taken. If the patient cannot maintain tension in the muscle for the entire test period, a nerve will be stimulated to activate the muscle. A thin needle is inserted near the nerve, and a series of small electrical shocks are given to activate a nerve fiber. The electromyography needle is inserted into the muscle to measure the response, as described above. A neurologist receiving specialized training in clinical neurophysiology will do the electromyography procedure under the direct supervision of an experienced neurologist.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Feb 2000
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2000
CompletedFirst Submitted
Initial submission to the registry
February 4, 2000
CompletedFirst Posted
Study publicly available on registry
February 7, 2000
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2005
CompletedMarch 4, 2008
November 1, 2005
February 4, 2000
March 3, 2008
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- Adult patients with weakness or motor dysfunction: 8/year.
- Normal volunteers, adults: 2/year.
You may not qualify if:
- Anticoagulation or uncorrected bleeding disorder.
- Children are not optimal subjects for fellows undergoing training in these techniques and will be excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892, United States
Related Publications (2)
Sanders DB, Stalberg EV. AAEM minimonograph #25: single-fiber electromyography. Muscle Nerve. 1996 Sep;19(9):1069-83. doi: 10.1002/(SICI)1097-4598(199609)19:93.0.CO;2-Y.
PMID: 8761262BACKGROUNDGrimby G, Stalberg E, Sandberg A, Sunnerhagen KS. An 8-year longitudinal study of muscle strength, muscle fiber size, and dynamic electromyogram in individuals with late polio. Muscle Nerve. 1998 Nov;21(11):1428-37. doi: 10.1002/(sici)1097-4598(199811)21:113.0.co;2-x.
PMID: 9771666BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Sponsor Type
- NIH
Study Record Dates
First Submitted
February 4, 2000
First Posted
February 7, 2000
Study Start
February 1, 2000
Study Completion
November 1, 2005
Last Updated
March 4, 2008
Record last verified: 2005-11