NCT00004353

Brief Summary

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia. II. Define the nature of the metabolic defect.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
35

participants targeted

Target at P25-P50 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1978

Completed
20.9 years until next milestone

First Submitted

Initial submission to the registry

October 18, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 19, 1999

Completed
Last Updated

July 10, 2008

Status Verified

April 1, 2002

First QC Date

October 18, 1999

Last Update Submit

July 9, 2008

Conditions

Mitochondrial MyopathyMELAS SyndromeLactic Acidosis

Keywords

MELAS syndromeinborn errors of metabolismlactic acidosismitochondrial myopathyrare disease

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
PROTOCOL ENTRY CRITERIA: * Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

University of California San Diego Medical Center

San Diego, California, 92103-8757, United States

Location

MeSH Terms

Conditions

Mitochondrial MyopathiesMELAS SyndromeAcidosis, LacticMetabolism, Inborn ErrorsRare Diseases

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal DiseasesNeuromuscular DiseasesNervous System DiseasesMitochondrial DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesMitochondrial EncephalomyopathiesBrain Diseases, Metabolic, InbornBrain Diseases, MetabolicBrain DiseasesCentral Nervous System DiseasesCerebral Small Vessel DiseasesCerebrovascular DisordersVascular DiseasesCardiovascular DiseasesGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesAcidosisAcid-Base ImbalanceDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Richard H. Haas

    University of California, San Diego

    STUDY CHAIR

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

October 18, 1999

First Posted

October 19, 1999

Study Start

December 1, 1978

Last Updated

July 10, 2008

Record last verified: 2002-04

Locations

US(1)