MELAS Syndrome
18
3
3
11
Key Insights
Highlights
Success Rate
100% trial completion (above average)
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 50/100
0.0%
0 terminated out of 18 trials
100.0%
+13.5% vs benchmark
6%
1 trials in Phase 3/4
18%
2 of 11 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 11 completed trials
Clinical Trials (18)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
A Study to Assess TTI-0102 vs Placebo in MELAS Patients
Global Registry and Natural History Study for Mitochondrial Disorders
L-Citrulline Dose Finding Safety Study in MELAS
Clinical Long Term Evaluation of Glutamine Supplement in MELAS Syndrome
Effectiveness of Ketogenic Diet in MELAS Syndrome
The KHENERGYZE Study
Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)
Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
Nitric Oxide Production in MELAS Syndrome
Mitochondrial nt3243 A>G Mutation in Taiwan
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
Ketones & Mitochondrial Heteroplasmy
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia
Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome