NCT00003906

Brief Summary

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells. PURPOSE: Randomized double-blinded clinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
19,747

participants targeted

Target at P75+ for phase_3 breast-cancer

Timeline
Completed

Started May 1999

Longer than P75 for phase_3 breast-cancer

Geographic Reach
3 countries

516 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 1999

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

November 1, 1999

Completed
3.2 years until next milestone

First Posted

Study publicly available on registry

January 27, 2003

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2005

Completed
6.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2012

Completed
Last Updated

October 6, 2015

Status Verified

October 1, 2015

Enrollment Period

6.6 years

First QC Date

November 1, 1999

Last Update Submit

October 5, 2015

Conditions

Keywords

breast cancer

Outcome Measures

Primary Outcomes (1)

  • Incidence of invasive breast cancer; superiority of one of the therapies.

    Determine which of the following is true: 1. compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer; 2. compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or 3. the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.

    Time from randomization to the occurance of invasive breast cancer.

Secondary Outcomes (6)

  • Effect of the study therapies on the incidence of intraductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS).

    Time from randomization to the occurance of DCIS or LCIS.

  • Effect of the study therapies on the incidence of endometrial cancer.

    Time from randomization to the occurance of endometrial cancer.

  • Effect of the study therapies on the incidence of ischemic heart disease.

    Time from randomization to the occurance of ischimic heart disease.

  • Effect of the study therapies on the incidence of fractures of the hip, spine, or Colles' fractures of the wrist.

    Time from randomization to the occurance of fractures of the hip, spine, or Colles' fractures of the wrist.

  • Effect of the study therapies on the toxicity and side effects of each therapy.

    Incidences of protocol defined toxicities and side effects.

  • +1 more secondary outcomes

Study Arms (2)

Group 1

ACTIVE COMPARATOR

Tamoxifen and placebo

Drug: Tamoxifen

Group 2

EXPERIMENTAL

Raloxifene and Placebo

Drug: Raloxifene

Interventions

60 mg/day plus placebo for 5 years

Group 2

20 mg/day plus placebo for 5 years

Group 1

Eligibility Criteria

Age35 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS: * Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria: * At least 12 months since spontaneous menstrual bleeding * Prior documented hysterectomy and bilateral salpingo-oophorectomy * At least 55 years of age with prior hysterectomy with or without oophorectomy * Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range * Histologically confirmed lobular carcinoma in situ treated by local excision only OR a minimum projected 5 year probability of invasive breast cancer of at least 1.66%, using Breast Cancer Risk Assessment Profile * No clinical evidence of malignancy on physical exam within the past 180 days * No evidence of suspicious or malignant disease on bilateral mammogram within the past year * No bilateral or unilateral prophylactic mastectomy * No prior invasive breast cancer or intraductal carcinoma in situ * Hormone receptor status: * Not specified PATIENT CHARACTERISTICS: Age: * 35 and over Sex: * Female Menopausal status: * See Disease Characteristics Performance status: * No restricted normal activity for a significant portion of each day Life expectancy: * At least 10 years Hematopoietic: * Granulocyte count at least 1,500/mm\^3 * Complete blood count and differential normal * Platelet count normal Hepatic: * SGOT or SGPT normal * Bilirubin normal * Alkaline phosphatase normal Renal: * Creatinine normal Cardiovascular: * No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension * No deep vein thrombosis Pulmonary: * No pulmonary embolus Other: * No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix * No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene * No clinical depression, psychiatric condition, or addictive disorder * No uncontrolled diabetes PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * Not specified Endocrine therapy: * At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens * At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration * Concurrent Estring allowed Radiotherapy: * No prior breast radiotherapy Surgery: * See Disease Characteristics Other: * No prior systemic adjuvant therapy for breast cancer * No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s) * NSABP-P-1 patients who received placebo are eligible * No concurrent warfarin or cholestyramine * Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (516)

Comprehensive Cancer Institute

Huntsville, Alabama, 35801, United States

Location

MBCCOP - Gulf Coast

Mobile, Alabama, 36688, United States

Location

Providence Alaska Medical Center

Anchorage, Alaska, 99519-6604, United States

Location

CCOP - Western Regional, Arizona

Phoenix, Arizona, 85006-2726, United States

Location

CCOP - Mayo Clinic Scottsdale Oncology Program

Scottsdale, Arizona, 85259-5404, United States

Location

Arizona Cancer Center at University of Arizona Health Sciences Center

Tucson, Arizona, 85724, United States

Location

Breast Associates

Fayetteville, Arkansas, 72703, United States

Location

Surgical Associates

Fort Smith, Arkansas, 72917, United States

Location

Northeast Arkansas Clinic

Jonesboro, Arkansas, 72401, United States

Location

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Location

Kaiser Permanente Medical Center - Anaheim/Orange County

Anaheim, California, 92805, United States

Location

Kaiser Permanente Medical Center - Baldwin Park

Baldwin Park, California, 91706, United States

Location

Kaiser Permanente Medical Center - Bellflower

Bellflower, California, 90706, United States

Location

Alta Bates Comprehensive Cancer Center

Berkeley, California, 94704, United States

Location

Providence Saint Joseph Medical Center - Burbank

Burbank, California, 91505, United States

Location

Mills-Peninsula Health Services

Burlingame, California, 94010, United States

Location

Enloe Cancer Center at Enloe Medical Center

Chico, California, 95926, United States

Location

Mount Diablo Medical Center

Concord, California, 94524-4110, United States

Location

Corona Regional Medical Center

Corona, California, 92882-3400, United States

Location

City of Hope Comprehensive Cancer Center

Duarte, California, 91010-3000, United States

Location

Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas

Encinitas, California, 92024, United States

Location

North Bay Cancer Center

Fairfield, California, 94533, United States

Location

Kaiser Permanente Medical Center - Fontana

Fontana, California, 92335, United States

Location

Crosson Cancer Center at St. Jude Medical Center

Fullerton, California, 92835, United States

Location

Glendale Memorial Hospital Comprehensive Cancer Center

Glendale, California, 91204, United States

Location

Oncology/Hematology Associates

Granada Hills, California, 91344, United States

Location

Marin General Hospital Cancer Institute

Greenbrae, California, 94904, United States

Location

Kaiser Permanente Medical Center - Harbor City

Harbor City, California, 90710, United States

Location

Hemet Valley Medical Center

Hemet, California, 92543, United States

Location

Rebecca and John Moores UCSD Cancer Center

La Jolla, California, 92093-0658, United States

Location

Valley Tumor Medical Group

Lancaster, California, 93534, United States

Location

Loma Linda University Cancer Institute at Loma Linda University Medical Center

Loma Linda, California, 92354, United States

Location

Todd Cancer Institute at Long Beach Memorial Medical Center

Long Beach, California, 90801-1428, United States

Location

Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach

Long Beach, California, 90813, United States

Location

Kaiser Permanente Medical Center - Los Angeles

Los Angeles, California, 90027, United States

Location

USC/Norris Comprehensive Cancer Center and Hospital

Los Angeles, California, 90033-0804, United States

Location

Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center

Los Angeles, California, 90033, United States

Location

Kaiser Foundation Hospital - West Los Angeles

Los Angeles, California, 90034, United States

Location

St. Vincent Medical Center - Los Angeles

Los Angeles, California, 90057-1901, United States

Location

Jonsson Comprehensive Cancer Center, UCLA

Los Angeles, California, 90095-1781, United States

Location

Mission Cancer Center at Mission Hospital

Mission Viejo, California, 92691, United States

Location

Sutter Gould Medical Foundation

Modesto, California, 95353, United States

Location

Leavey Cancer Center at Northridge Hospital Medical Center

Northridge, California, 91328, United States

Location

Breast Health Center

Oceanside, California, 92056, United States

Location

St. Joseph Hospital Regional Cancer Center - Orange

Orange, California, 92868-3849, United States

Location

Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center

Orange, California, 92868, United States

Location

Ventura Hematology - Oncology Specialists - Oxnard

Oxnard, California, 93030, United States

Location

Comprehensive Cancer Centers of the Desert

Palm Springs, California, 92262, United States

Location

Palo Alto Medical Foundation

Palo Alto, California, 95819-5156, United States

Location

Kaiser Permanente Medical Group

Panorama City, California, 91402, United States

Location

Huntington Cancer Center at Huntington Hospital

Pasadena, California, 91109-7013, United States

Location

Wilshire Oncology Medical Group, Incorporated - Pomona

Pomona, California, 91767-3021, United States

Location

North Valley Breast Clinic

Redding, California, 96001, United States

Location

Kaiser Permanente Medical Center - Riverside

Riverside, California, 92505, United States

Location

Sutter Roseville Medical Center

Roseville, California, 95661, United States

Location

Sutter Breast Cancer Group

Sacramento, California, 95819-5156, United States

Location

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego

San Diego, California, 92120, United States

Location

Naval Medical Center - San Diego

San Diego, California, 92134-3202, United States

Location

California Pacific Medical Center - California Campus

San Francisco, California, 94118-1618, United States

Location

UCSF Comprehensive Cancer Center

San Francisco, California, 94143-0128, United States

Location

Cancer Center of Santa Barbara

Santa Barbara, California, 93105, United States

Location

CCOP - Santa Rosa Memorial Hospital

Santa Rosa, California, 95403, United States

Location

Stanford Cancer Center at Stanford University Medical Center

Stanford, California, 94305-5408, United States

Location

Torrance Memorial Medical Center

Torrance, California, 90505, United States

Location

Santa Clarita Valley Cancer Center - UCLA

Valencia, California, 91355, United States

Location

Kaiser Permanente Medical Center - Vallejo

Vallejo, California, 94589, United States

Location

Kaiser Permanente Medical Cener - Woodland Hills

Woodland Hills, California, 91365-4084, United States

Location

Penrose Cancer Center

Colorado Springs, Colorado, 80933, United States

Location

CCOP - Colorado Cancer Research Program, Incorporated

Denver, Colorado, 80209-5031, United States

Location

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

Location

St. Mary-Corwin Regional Medical Center

Pueblo, Colorado, 81004, United States

Location

University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center

Farmington, Connecticut, 06360-7106, United States

Location

Hartford Hospital

Hartford, Connecticut, 06102-5037, United States

Location

St. Francis Hospital and Medical Center

Hartford, Connecticut, 06105, United States

Location

Manchester Memorial Hospital

Manchester, Connecticut, 06040-4188, United States

Location

Midstate Medical Center

Meriden, Connecticut, 06451, United States

Location

New Britain General Hospital

New Britain, Connecticut, 06050, United States

Location

Hospital of St. Raphael

New Haven, Connecticut, 06511, United States

Location

Yale Comprehensive Cancer Center

New Haven, Connecticut, 06520-8028, United States

Location

Lawrence and Memorial Hospital

New London, Connecticut, 06320, United States

Location

Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States

Location

Hematology Oncology, P.C.

Stamford, Connecticut, 06902, United States

Location

Northwestern Connecticut Oncology-Hematology Associates

Torrington, Connecticut, 06790, United States

Location

Windham Community Memorial Hospital

Williamantic, Connecticut, 06226, United States

Location

Beebe Medical Center

Lewes, Delaware, 19958, United States

Location

Nanticoke Memorial Hospital

Seaford, Delaware, 19973, United States

Location

CCOP - Christiana Care Health Services

Wilmington, Delaware, 19899, United States

Location

Lombardi Cancer Center at Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States

Location

Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

Location

Providence Hospital

Washington D.C., District of Columbia, 20017, United States

Location

JFK Medical Center

Atlantis, Florida, 33462, United States

Location

St. Vincent's Medical Center

Jacksonville, Florida, 32203, United States

Location

Baptist Regional Cancer Institute - Jacksonville

Jacksonville, Florida, 32207, United States

Location

Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States

Location

Ella Milbank Foshay Cancer Center at Jupiter Medical Center

Jupiter, Florida, 33458, United States

Location

Watson Clinic

Lakeland, Florida, 33804-5000, United States

Location

Lakeland Regional Cancer Center at Lakeland Regional Medical Center

Lakeland, Florida, 33804, United States

Location

University of Miami Sylvester Cancer Center

Miami, Florida, 33136, United States

Location

CCOP - Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States

Location

Florida Hospital Medical Center

Orlando, Florida, 32803-1273, United States

Location

MD Anderson Cancer Center Orlando

Orlando, Florida, 32806, United States

Location

West Florida Regional Medical Center

Pensacola, Florida, 32514-6088, United States

Location

Cancer Research Network Inc.

Plantation, Florida, 33324, United States

Location

Clinical Research Center of South Florida

Stuart, Florida, 34996, United States

Location

H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612-9497, United States

Location

Palm Beach Cancer Institute

West Palm Beach, Florida, 33401, United States

Location

CCOP - Atlanta Regional

Atlanta, Georgia, 30342-1701, United States

Location

Medical College of Georgia

Augusta, Georgia, 30912, United States

Location

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

Savannah, Georgia, 31403-3089, United States

Location

Cancer Care and Research Pavilion at St. Joseph's/Candler

Savannah, Georgia, 31405-6013, United States

Location

MBCCOP - Hawaii

Honolulu, Hawaii, 96813, United States

Location

North Idaho Cancer Center

Coeur d'Alene, Idaho, 83814, United States

Location

Northwest Community Hospital

Arlington Heights, Illinois, 60005, United States

Location

Rush Copley Medical Center

Aurora, Illinois, 60504-4206, United States

Location

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Chicago, Illinois, 60611-3013, United States

Location

Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States

Location

MBCCOP - University of Illinois at Chicago

Chicago, Illinois, 60612-7323, United States

Location

John H. Stroger, Jr. Hospital of Cook County

Chicago, Illinois, 60612-9985, United States

Location

Rush Cancer Institute at Rush University Medical Center

Chicago, Illinois, 60612, United States

Location

Resurrection Medical Center

Chicago, Illinois, 60631, United States

Location

Our Lady of the Resurrection Medical Center

Chicago, Illinois, 60634, United States

Location

University of Chicago Cancer Research Center

Chicago, Illinois, 60637-1470, United States

Location

Creticos Cancer Center at Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States

Location

CCOP - Central Illinois

Decatur, Illinois, 62526, United States

Location

Sherman Hospital

Elgin, Illinois, 60120-2198, United States

Location

CCOP - Evanston

Evanston, Illinois, 60201, United States

Location

St. Francis Hospital

Evanston, Illinois, 60202, United States

Location

Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States

Location

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States

Location

Evanston Northwestern Health Care - Highland Park Hospital

Highland Park, Illinois, 60035-2497, United States

Location

Hinsdale Hematology Oncology Associates

Hinsdale, Illinois, 60521, United States

Location

Joliet Oncology Hematology Associates, Limited - Joliet

Joliet, Illinois, 60435, United States

Location

Cardinal Bernardin Cancer Center at Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

Edward Hospital Cancer Center

Naperville, Illinois, 60540-7499, United States

Location

Mid-Illinois Hematology-Oncology Associates

Normal, Illinois, 61761, United States

Location

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453, United States

Location

Saint James Hospital and Health Centers Comprehensive Cancer Institute

Olympia Fields, Illinois, 60461, United States

Location

Lutheran General Cancer Care Center

Park Ridge, Illinois, 60068, United States

Location

CCOP - Illinois Oncology Research Association

Peoria, Illinois, 61602, United States

Location

Trinity Medical Center - West

Rock Island, Illinois, 61201, United States

Location

Rockford Clinic

Rockford, Illinois, 61103, United States

Location

Swedish-American Regional Cancer Center

Rockford, Illinois, 61104-2315, United States

Location

Saint Anthony Medical Center

Rockford, Illinois, 61108, United States

Location

Edward H. Kaplan MD and Associates

Skokie, Illinois, 60076, United States

Location

St. John's Hospital

Springfield, Illinois, 62769, United States

Location

Memorial Medical Center

Springfield, Illinois, 62781, United States

Location

CCOP - Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

Center for Cancer Care at Goshen Health System

Goshen, Indiana, 46526, United States

Location

Indiana Community Cancer Care, Incorporated

Indianapolis, Indiana, 46202, United States

Location

Methodist Cancer Center at Methodist Hospital

Indianapolis, Indiana, 46206-1367, United States

Location

Indiana Regional Cancer Center

Indianapolis, Indiana, 46256, United States

Location

St. Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260, United States

Location

Oncology Institute of Greater Lafayette

Lafayette, Indiana, 47904, United States

Location

Saint Anthony Memorial Health Centers

Michigan City, Indiana, 46360, United States

Location

Ball Memorial Hospital Cancer Center

Muncie, Indiana, 47303-3499, United States

Location

Community Hospital

Munster, Indiana, 46321, United States

Location

CCOP - Northern Indiana CR Consortium

South Bend, Indiana, 46601, United States

Location

McFarland Clinic, P.C.

Ames, Iowa, 50010, United States

Location

CCOP - Cedar Rapids Oncology Project

Cedar Rapids, Iowa, 52403-1206, United States

Location

Medical Associates

Clinton, Iowa, 52732-5031, United States

Location

Jennie Edmundson Memorial Hospital

Council Bluffs, Iowa, 51503, United States

Location

Genesis Regional Cancer Center at Genesis Medical Center

Davenport, Iowa, 52803, United States

Location

CCOP - Iowa Oncology Research Association

Des Moines, Iowa, 50309-1016, United States

Location

Wendt Regional Cancer Center of Finley Hospital

Dubuque, Iowa, 52001, United States

Location

Holden Comprehensive Cancer Center at University of Iowa

Iowa City, Iowa, 52242-1009, United States

Location

Mercy Cancer Center at Mercy Medical Center - North Iowa

Mason City, Iowa, 50401, United States

Location

Ottumwa Regional Health Center

Ottumwa, Iowa, 52501, United States

Location

Siouxland Hematology-Oncology

Sioux City, Iowa, 51101-1733, United States

Location

Cedar Valley Medical Specialists, P.C.

Waterloo, Iowa, 50701, United States

Location

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

Kansas City, Kansas, 66160-7357, United States

Location

CCOP - Wichita

Wichita, Kansas, 67214-3882, United States

Location

King's Daughters Medical Center

Ashland, Kentucky, 41101, United States

Location

St. Elizabeth Medical Center

Edgewood, Kentucky, 41017, United States

Location

HCA Kings Daughters Memorial Hospital

Frankfort, Kentucky, 40601, United States

Location

Central Baptist Hospital

Lexington, Kentucky, 40503, United States

Location

Markey Cancer Center at University of Kentucky Chandler Medical Center

Lexington, Kentucky, 40536-0093, United States

Location

Norton Healthcare Cancer Center

Louisville, Kentucky, 40202-5070, United States

Location

James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States

Location

Baptist Hospital East - Louisville

Louisville, Kentucky, 40207, United States

Location

Ochsner Clinic of Baton Rouge

Baton Rouge, Louisiana, 70809, United States

Location

Baton Rouge General Medical Center

Baton Rouge, Louisiana, 70821-2511, United States

Location

Cancer Care Specialists

Houma, Louisiana, 70360, United States

Location

MBCCOP - LSU Health Sciences Center

New Orleans, Louisiana, 70112, United States

Location

Tulane Cancer Center at Tulane University Hospital and Clinic

New Orleans, Louisiana, 70112, United States

Location

CCOP - Ochsner

New Orleans, Louisiana, 70121, United States

Location

Cancer Treatment Center at Christus Schumpert St. Mary Place

Shreveport, Louisiana, 71101, United States

Location

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

Location

Goodall Hospital

Sanford, Maine, 04073, United States

Location

Maine Center for Cancer Medicine and Blood Disorders - Scarborough

Scarborough, Maine, 04074, United States

Location

Anne Arundel Medical Center

Annapolis, Maryland, 21401, United States

Location

Greenebaum Cancer Center at University of Maryland Medical Center

Baltimore, Maryland, 21201, United States

Location

Greater Baltimore Medical Center and Cancer Center

Baltimore, Maryland, 21204, United States

Location

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231-2410, United States

Location

Franklin Square Hospital Center

Baltimore, Maryland, 21237, United States

Location

Suburban Hospital

Bethesda, Maryland, 20814, United States

Location

Frederick Memorial Hospital Regional Cancer Therapy Center

Frederick, Maryland, 21701, United States

Location

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

Location

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute

Boston, Massachusetts, 02115, United States

Location

Cancer Research Center at Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Harvard Vanguard Medical Associates - Kenmore

Boston, Massachusetts, 02215, United States

Location

Lahey Clinic Medical Center - Burlington

Burlington, Massachusetts, 01805, United States

Location

Saint Anne's Hospital

Fall River, Massachusetts, 02721, United States

Location

Caritas Norwood Hospital

Norfolk, Massachusetts, 02062, United States

Location

NSMC Cancer Center

Peabody, Massachusetts, 01960, United States

Location

Berkshire Physicians and Surgeons, P.C.

Pittsfield, Massachusetts, 01201, United States

Location

Jordan Hospital Club Cancer Center

Plymouth, Massachusetts, 02360, United States

Location

Baystate Regional Cancer Program at Baystate Medical Center

Springfield, Massachusetts, 01199, United States

Location

University of Massachusetts Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States

Location

Hickman Cancer Center at Bixby Medical Center

Adrian, Michigan, 49221, United States

Location

CCOP - Michigan Cancer Research Consortium

Ann Arbor, Michigan, 48106, United States

Location

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109-0752, United States

Location

Battle Creek Health System

Battle Creek, Michigan, 49016, United States

Location

Bay Diagnostic Center for Women

Bay City, Michigan, 48708, United States

Location

Community Health Center of Branch County

Coldwater, Michigan, 49036, United States

Location

Oakwood Hospital and Medical Center

Dearborn, Michigan, 48123-2500, United States

Location

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201-1379, United States

Location

Josephine Ford Cancer Center at Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

St. John Hospital and Medical Center

Detroit, Michigan, 48236, United States

Location

Hurley Medical Center

Flint, Michigan, 48503, United States

Location

Flint Hematology Oncology

Flint, Michigan, 48532, United States

Location

Genesys Regional Medical Center

Grand Blanc, Michigan, 48439-8066, United States

Location

CCOP - Grand Rapids

Grand Rapids, Michigan, 49503, United States

Location

Holland Community Hospital

Holland, Michigan, 49423, United States

Location

Center for Hematology/Oncology

Jackson, Michigan, 49201, United States

Location

CCOP - Kalamazoo

Kalamazoo, Michigan, 49007-3731, United States

Location

Michigan State University Department of Surgery

Lansing, Michigan, 48912, United States

Location

Lapeer Regional Hospital

Lapeer, Michigan, 48446, United States

Location

Marquette General Hospital

Marquette, Michigan, 49855, United States

Location

Mercy Memorial Hospital, Corporation

Monroe, Michigan, 48161-0067, United States

Location

Community Cancer Care Specialist

Mount Clemens, Michigan, 48043, United States

Location

Memorial Healthcare

Owosso, Michigan, 48867, United States

Location

Blue Water Oncology PC, Port Huron

Port Huron, Michigan, 48060, United States

Location

CCOP - Beaumont

Royal Oak, Michigan, 48073-6769, United States

Location

Saint Mary's Seton Cancer Institute

Saginaw, Michigan, 48601, United States

Location

Providence Cancer Institute at Providence Hospital

Southfield, Michigan, 48075-9975, United States

Location

Munson Medical Center

Traverse City, Michigan, 49684, United States

Location

St. John Macomb Hospital

Warren, Michigan, 48093-3494, United States

Location

CCOP - Duluth

Duluth, Minnesota, 55805, United States

Location

St. Luke's Medical Clinic

Duluth, Minnesota, 55805, United States

Location

Minnesota Cooperative Group Program

Minneapolis, Minnesota, 55407, United States

Location

Hennepin County Medical Center - Minneapolis

Minneapolis, Minnesota, 55415, United States

Location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Mayo Clinic Cancer Center

Rochester, Minnesota, 55905, United States

Location

CCOP - Metro-Minnesota

Saint Louis Park, Minnesota, 55416, United States

Location

Rice Memorial Hospital

Willmar, Minnesota, 56201, United States

Location

Coast Oncology/Hematology, P.L.L.C.

Biloxi, Mississippi, 39530-4239, United States

Location

Mid Delta Family Practice

Cleveland, Mississippi, 38732, United States

Location

Hattiesburg Clinic, P.A.

Hattiesburg, Mississippi, 39401, United States

Location

Jackson Oncology Associates, PLLC

Jackson, Mississippi, 39202, United States

Location

Keesler Medical Center - Keesler Air Force Base

Keesler Air Force Base, Mississippi, 39534-2576, United States

Location

North Mississippi Hematology and Oncology Associates, Limited

Tupelo, Mississippi, 38801, United States

Location

Saint Luke's Hospital

Chesterfield, Missouri, 63017, United States

Location

Ellis Fischel Cancer Center at University of Missouri - Columbia

Columbia, Missouri, 65203, United States

Location

Freeman Cancer Institute at Freeman Health System

Joplin, Missouri, 64803-2644, United States

Location

St. John's Regional Medical Center

Joplin, Missouri, 64804, United States

Location

CCOP - Kansas City

Kansas City, Missouri, 64131, United States

Location

Phelps County Regional Medical Center

Rolla, Missouri, 65401, United States

Location

Missouri Cancer Care, P.C. - St. Charles

Saint Charles, Missouri, 63301, United States

Location

St. John's Regional Health Center

Springfield, Missouri, 65804, United States

Location

CCOP - Cancer Research for the Ozarks

Springfield, Missouri, 65807, United States

Location

Midwest Hematology Oncology Group, Inc.

St Louis, Missouri, 63109, United States

Location

Siteman Cancer Center

St Louis, Missouri, 63110, United States

Location

Missouri Baptist Cancer Center

St Louis, Missouri, 63131, United States

Location

CCOP - St. Louis-Cape Girardeau

St Louis, Missouri, 63141, United States

Location

Ozarks Medical Center

West Plains, Missouri, 65775, United States

Location

CCOP - Montana Cancer Consortium

Billings, Montana, 59101, United States

Location

Montana Cancer Institute - Benefis Healthcare

Great Falls, Montana, 59405, United States

Location

Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States

Location

Saint Francis Medical Center

Grand Island, Nebraska, 68802, United States

Location

Cancer Center at the Good Samaritan Health Systems

Kearney, Nebraska, 68848-1990, United States

Location

Cancer Resource Center - Lincoln

Lincoln, Nebraska, 68510-4844, United States

Location

Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha

Omaha, Nebraska, 68114, United States

Location

Alegent Health - Immanuel Medical Center

Omaha, Nebraska, 68122, United States

Location

Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

Location

Creighton University Medical Center

Omaha, Nebraska, 68131-2197, United States

Location

CCOP - Southern Nevada Cancer Research Foundation

Las Vegas, Nevada, 89106, United States

Location

New Hampshire Oncology-Hematology, PA - Hooksett

Hooksett, New Hampshire, 03106, United States

Location

Southern New Hampshire Medical Center

Nashua, New Hampshire, 03061, United States

Location

Cooper Cancer Institute

Camden, New Jersey, 08103, United States

Location

Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States

Location

Hunterdon Regional Cancer Center

Flemington, New Jersey, 08822, United States

Location

CCOP - Northern New Jersey

Hackensack, New Jersey, 07601, United States

Location

St. Barnabas Medical Center

Livingston, New Jersey, 07039, United States

Location

Monmouth Medical Center

Long Branch, New Jersey, 07740-6395, United States

Location

South Jersey Regional Cancer Center

Millville, New Jersey, 08332, United States

Location

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital

Mount Holly, New Jersey, 08060, United States

Location

Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

Location

Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States

Location

Warren Hospital

Phillipsburg, New Jersey, 08865, United States

Location

Atlantic City Medical Center

Pomona, New Jersey, 08240, United States

Location

Booker Cancer Center at Riverview Medical Center

Red Bank, New Jersey, 07701, United States

Location

Valley Hospital

Ridgewood, New Jersey, 07450, United States

Location

Somerset Medical Center

Somerville, New Jersey, 08876, United States

Location

Community Medical Center

Toms River, New Jersey, 08755, United States

Location

Capital Health System at Mercer

Trenton, New Jersey, 08607, United States

Location

Underwood Memorial Hospital

Woodbury, New Jersey, 08096, United States

Location

Hematology-Oncology Associates, PC

Albuquerque, New Mexico, 87102, United States

Location

Lovelace Medical Center at Lovelace Sandia Health System

Albuquerque, New Mexico, 87108, United States

Location

New Mexico Oncology-Hematology Consultants, Limited

Albuquerque, New Mexico, 87109, United States

Location

University of New Mexico Cancer Research and Treatment Center

Albuquerque, New Mexico, 87131, United States

Location

New Mexico Cancer Care Associates

Santa Fe, New Mexico, 87505-7670, United States

Location

New York Oncology Hematology, P.C. - Albany Regional Cancer Center

Albany, New York, 12208, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263-0001, United States

Location

Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital

Cooperstown, New York, 13326-1394, United States

Location

Charles R. Wood Foundation Cancer Center at Glens Falls Hospital

Glens Falls, New York, 12801, United States

Location

Queens Cancer Center of Queens Hospital

Jamaica, New York, 11432, United States

Location

New York Oncology Hematology, P.C. - Latham

Latham, New York, 12110-0610, United States

Location

CCOP - North Shore University Hospital

Manhasset, New York, 11030, United States

Location

Saint Vincent Catholic Medical Center of New York

New York, New York, 10011, United States

Location

NYU School of Medicine's Kaplan Comprehensive Cancer Center

New York, New York, 10016, United States

Location

Memorial Sloan-Kettering Cancer Center

New York, New York, 10021, United States

Location

Herbert Irving Comprehensive Cancer Center at Columbia University

New York, New York, 10032, United States

Location

St. Francis Hospital and Health Centers

Poughkeepsie, New York, 12601, United States

Location

Vassar Brothers Medical Center

Poughkeepsie, New York, 12601, United States

Location

Genesee Surgical Associates

Rochester, New York, 14607, United States

Location

Gynecologic Oncology Associates

Rochester, New York, 14620, United States

Location

James P. Wilmot Cancer Center at University of Rochester Medical Center

Rochester, New York, 14642, United States

Location

University Hospital - Stony Brook

Stony Brook, New York, 11794-8174, United States

Location

University Hospital at State University of New York - Upstate Medical University

Syracuse, New York, 13210, United States

Location

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.

Syracuse, New York, 13217, United States

Location

Albert Einstein Clinical Cancer Center

The Bronx, New York, 10461, United States

Location

Comprehensive Cancer Center at Our Lady of Mercy Medical Center

The Bronx, New York, 10466, United States

Location

Mission Hospitals

Asheville, North Carolina, 28801, United States

Location

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27599-7295, United States

Location

Blumenthal Cancer Center at Carolinas Medical Center

Charlotte, North Carolina, 28232-2861, United States

Location

Presbyterian Healthcare

Charlotte, North Carolina, 28233-3549, United States

Location

Duke Comprehensive Cancer Center

Durham, North Carolina, 27710, United States

Location

Cape Fear Valley Health System

Fayetteville, North Carolina, 28302-2000, United States

Location

Gaston Hematology and Oncology

Gastonia, North Carolina, 28054, United States

Location

Southeastern Medical Oncology Center

Goldsboro, North Carolina, 27534, United States

Location

Moses Cone Regional Cancer Center at Wesley Long Community Hospital

Greensboro, North Carolina, 27403-1199, United States

Location

Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina

Greenville, North Carolina, 27858-4354, United States

Location

Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States

Location

Cornerstone Surgery

High Point, North Carolina, 27262, United States

Location

Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center

Raleigh, North Carolina, 27607, United States

Location

Cancer Center at Iredell Memorial Hospital

Statesville, North Carolina, 28687-1828, United States

Location

New Hanover Regional Medical Center

Wilmington, North Carolina, 28402-9000, United States

Location

Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States

Location

CCOP - Southeast Cancer Control Consortium

Winston-Salem, North Carolina, 27104-4241, United States

Location

Comprehensive Cancer Center at Wake Forest University

Winston-Salem, North Carolina, 27157-1082, United States

Location

Quain & Ramstad Clinic

Bismarck, North Dakota, 58501, United States

Location

CCOP - Merit Care Hospital

Fargo, North Dakota, 58122, United States

Location

Akron General Medical Center

Akron, Ohio, 44302, United States

Location

Mercy Medical Center

Canton, Ohio, 44708, United States

Location

Aultman Hospital Cancer Center at Aultman Health Foundation

Canton, Ohio, 44710, United States

Location

Cancer Center at Christ Hospital

Cincinnati, Ohio, 45219, United States

Location

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

Location

Charles M. Barrett Cancer Center at University Hospital

Cincinnati, Ohio, 45267-0502, United States

Location

Ireland Cancer Center

Cleveland, Ohio, 44106-5065, United States

Location

Fairview Hospital

Cleveland, Ohio, 44111, United States

Location

Kaiser Permanente

Cleveland, Ohio, 44120, United States

Location

Cleveland Clinic Taussig Cancer Center

Cleveland, Ohio, 44195, United States

Location

CCOP - Columbus

Columbus, Ohio, 43206, United States

Location

Arthur G. James Cancer Hospital - Ohio State University

Columbus, Ohio, 43210-1240, United States

Location

Blanchard Valley Medical Associates

Findlay, Ohio, 45840, United States

Location

Fremont Memorial Hospital

Fremont, Ohio, 43420, United States

Location

Cleveland Clinic Cancer Center

Independence, Ohio, 44131, United States

Location

CCOP - Dayton

Kettering, Ohio, 45429, United States

Location

Lima Memorial Hospital

Lima, Ohio, 45804, United States

Location

St. Luke's Hospital

Maumee, Ohio, 43537, United States

Location

Parma Community General Hospital

Parma, Ohio, 44129, United States

Location

Firelands Regional Medical Center

Sandusky, Ohio, 44870, United States

Location

Flower Hospital - ProMedica Health System

Sylvania, Ohio, 43560, United States

Location

Toledo Hospital

Toledo, Ohio, 43606, United States

Location

St. Vincent Mercy Medical Center

Toledo, Ohio, 43608, United States

Location

Medical College of Ohio Cancer Institute

Toledo, Ohio, 43614-0008, United States

Location

St. Charles Hospital

Toledo, Ohio, 43616, United States

Location

CCOP - Toledo Community Hospital

Toledo, Ohio, 43623, United States

Location

Toledo Clinic, Incorporated

Toledo, Ohio, 43623, United States

Location

Cleveland Clinic Health System STAR BCPT

Warrensville Heights, Ohio, 44122, United States

Location

Fulton County Health Center

Wauseon, Ohio, 43567, United States

Location

Muskogee Regional Medical Center

Muskogee, Oklahoma, 74401, United States

Location

Frank C. Love Cancer Institute at St. Anthony Hospital

Oklahoma City, Oklahoma, 73101, United States

Location

Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center

Oklahoma City, Oklahoma, 73109, United States

Location

Mercy Health Center

Oklahoma City, Oklahoma, 73120, United States

Location

Oklahoma University Medical Center at University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73190, United States

Location

St. John Health System

Tulsa, Oklahoma, 74104, United States

Location

CCOP - Oklahoma

Tulsa, Oklahoma, 74136, United States

Location

St. Charles Medical Center

Bend, Oregon, 97701, United States

Location

Cancer Institute at Oregon Health and Science University

Portland, Oregon, 97201-3098, United States

Location

CCOP - Columbia River Oncology Program

Portland, Oregon, 97213, United States

Location

Kaiser Permanente Center for Health Research

Portland, Oregon, 97227-1098, United States

Location

Abington Memorial Hospital

Abington, Pennsylvania, 19001, United States

Location

Sacred Heart Hospital

Allentown, Pennsylvania, 18102, United States

Location

John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital

Allentown, Pennsylvania, 18103, United States

Location

Bon Secours-Holy Family Health System

Altoona, Pennsylvania, 16602, United States

Location

St. Luke's Hospital Cancer Center

Bethlehem, Pennsylvania, 18015, United States

Location

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822-2001, United States

Location

Mercy Fitzgerald Hospital

Darby, Pennsylvania, 19023, United States

Location

Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States

Location

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026, United States

Location

Easton Hospital

Easton, Pennsylvania, 18042, United States

Location

Ephrata Community Hopital

Ephrata, Pennsylvania, 17522-1002, United States

Location

Regional Cancer Center - Erie

Erie, Pennsylvania, 16505, United States

Location

Pinnacle Health Regional Cancer Center at Pinnacle Health System

Harrisburg, Pennsylvania, 17105-8700, United States

Location

Mercy Community Hospital

Havertown, Pennsylvania, 19083, United States

Location

Penn State Cancer Institute at Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

Location

Lancaster General Hospital

Lancaster, Pennsylvania, 17604-3555, United States

Location

Saint Mary Regional Cancer Center

Langhorne, Pennsylvania, 19047, United States

Location

Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States

Location

Cancer Center at Paoli Memorial Hospital

Paoli, Pennsylvania, 19301-1792, United States

Location

Abramson Cancer Center at University of Pennsylvania Medical Center

Philadelphia, Pennsylvania, 19104-4283, United States

Location

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

Philadelphia, Pennsylvania, 19107-5541, United States

Location

Pennsylvania Oncology Hematology Associates

Philadelphia, Pennsylvania, 19107, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

Frankford Hospital

Philadelphia, Pennsylvania, 19114, United States

Location

Chestnut Hill Healthcare

Philadelphia, Pennsylvania, 19118, United States

Location

Fox Chase - Temple Cancer Center

Philadelphia, Pennsylvania, 19140, United States

Location

Albert Einstein Cancer Center

Philadelphia, Pennsylvania, 19141, United States

Location

Mercy Hospital of Philadelphia

Philadelphia, Pennsylvania, 19143, United States

Location

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212-4772, United States

Location

Hillman Cancer Center at University of Pittsburgh Cancer Institute

Pittsburgh, Pennsylvania, 15213-3489, United States

Location

Pottstown Memorial Regional Cancer Center

Pottstown, Pennsylvania, 19464, United States

Location

Reading Hospital and Medical Center

Reading, Pennsylvania, 19612-6052, United States

Location

Grand View Hospital

Sellersville, Pennsylvania, 18960, United States

Location

Crozer-Chester Medical Center

Upland, Pennsylvania, 19013, United States

Location

Chester County Hospital

West Chester, Pennsylvania, 19380, United States

Location

Lankenau Cancer Center at Lankenau Hospital

Wynnewood, Pennsylvania, 19096, United States

Location

Wellspan Health - York Cancer Center

York, Pennsylvania, 17403, United States

Location

Rhode Island Hospital

Providence, Rhode Island, 02903, United States

Location

AnMed Health

Anderson, South Carolina, 29621, United States

Location

Roper St. Francis Healthcare - Roper Hospital

Charleston, South Carolina, 29401, United States

Location

Hollings Cancer Center at Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

Palmetto Richland Memorial Hospital

Columbia, South Carolina, 29203, United States

Location

McLeod Regional Medical Center

Florence, South Carolina, 29501, United States

Location

Cancer Centers of the Carolinas - Eastside

Greenville, South Carolina, 29601, United States

Location

CCOP - Upstate Carolina

Spartanburg, South Carolina, 29303, United States

Location

Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States

Location

CCOP - Sioux Community Cancer Consortium

Sioux Falls, South Dakota, 57104, United States

Location

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37662, United States

Location

Thompson Cancer Survival Center

Knoxville, Tennessee, 37916, United States

Location

U.T. Cancer Institute at University of Tennessee Medical Center

Knoxville, Tennessee, 37920-2911, United States

Location

Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis

Memphis, Tennessee, 38117, United States

Location

MBCCOP - Meharry Medical College - Nashville

Nashville, Tennessee, 37208-3599, United States

Location

Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center

Nashville, Tennessee, 37232-6838, United States

Location

Hendrick Cancer Center

Abilene, Texas, 79601-2316, United States

Location

Harrington Cancer Center

Amarillo, Texas, 79106, United States

Location

Julie and Ben Rogers Cancer Center

Beaumont, Texas, 77701, United States

Location

Presbyterian Hospital of Dallas

Dallas, Texas, 75231, United States

Location

Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas

Dallas, Texas, 75235-9154, United States

Location

Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States

Location

Methodist Dallas Medical Center

Dallas, Texas, 75265-5999, United States

Location

Providence Memorial Hospital

El Paso, Texas, 79902, United States

Location

Harris Methodist Fort Worth

Fort Worth, Texas, 76104, United States

Location

University of Texas - MD Anderson Cancer Center

Houston, Texas, 77030-4009, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

Texas Cancer Institute at St. Luke's Episcopal Hospital

Houston, Texas, 77030, United States

Location

Baylor Medical Center at Garland

Irving, Texas, 75061, United States

Location

Wilford Hall Medical Center

Lackland Air Force Base, Texas, 78236-5300, United States

Location

Sanchez Cancer Center

Laredo, Texas, 78041, United States

Location

Joe Arrington Cancer Research and Treatment Center

Lubbock, Texas, 79410-1894, United States

Location

Southwest Cancer and Research Center at University Medical Center

Lubbock, Texas, 79415, United States

Location

Memorial Health System of East Texas

Lufkin, Texas, 75902, United States

Location

Baylor/Richardson Cancer Center

Richardson, Texas, 75080, United States

Location

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78284-7811, United States

Location

CCOP - Scott and White Hospital

Temple, Texas, 76508, United States

Location

University of Texas Health Center at Tyler

Tyler, Texas, 75708, United States

Location

Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States

Location

Green Mountain Oncology Group

Bennington, Vermont, 05201, United States

Location

Southwestern Vermont Regional Cancer Center

Bennington, Vermont, 05201, United States

Location

Mountainview Medical

Berlin Corners, Vermont, 05602, United States

Location

Vermont Cancer Center at University of Vermont

Burlington, Vermont, 05401-3498, United States

Location

Community Cancer Center at Rutland Regional Medical Center

Rutland, Vermont, 05701, United States

Location

Martha Jefferson Hospital

Charlottesville, Virginia, 22901, United States

Location

Cancer Center of the Piedmont, Inc.

Danville, Virginia, 24541, United States

Location

Danville Hematology and Oncology, Incorporated

Danville, Virginia, 24541, United States

Location

Virginia Oncology Associates - Newport News

Newport News, Virginia, 23606, United States

Location

Henrico Doctors' Hospital - Parham Campus

Richmond, Virginia, 23229, United States

Location

MBCCOP - Massey Cancer Center

Richmond, Virginia, 23298-0037, United States

Location

Oncology and Hematology Associates of Southwest Virginia, Inc.

Roanoke, Virginia, 24014, United States

Location

St. Joseph Hospital Community Cancer Center

Bellingham, Washington, 98225, United States

Location

Olympic Hematology and Oncology

Bremerton, Washington, 98310, United States

Location

Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus

Everett, Washington, 98258-0000, United States

Location

CCOP - Virginia Mason Research Center

Seattle, Washington, 98101, United States

Location

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

Seattle, Washington, 98104, United States

Location

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109-1024, United States

Location

Cancer Care Northwest - Spokane North

Spokane, Washington, 99207, United States

Location

Rockwood Clinic P.S.

Spokane, Washington, 99220, United States

Location

CCOP - Northwest

Tacoma, Washington, 98405-0986, United States

Location

Yakima Regional Cancer Care Center

Yakima, Washington, 89802, United States

Location

David Lee Cancer Center at Charleston Area Medical Center

Charleston, West Virginia, 25304-1297, United States

Location

Camden-Clark Memorial Hospital

Parkersburg, West Virginia, 26102, United States

Location

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

Location

University of Wisconsin Comprehensive Cancer Center

Madison, Wisconsin, 53792-6164, United States

Location

CCOP - Marshfield Clinic Research Foundation

Marshfield, Wisconsin, 54449, United States

Location

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53201-0342, United States

Location

Oncology Alliance, S.C.

Milwaukee, Wisconsin, 53215, United States

Location

Medical College of Wisconsin Cancer Center

Milwaukee, Wisconsin, 53226, United States

Location

Waukesha Memorial Hospital Regional Cancer Center

Waukesha, Wisconsin, 53188, United States

Location

UW Cancer Center Wausau Hospital

Wausau, Wisconsin, 54401, United States

Location

Tom Baker Cancer Center - Calgary

Calgary, Alberta, T2N 4N2, Canada

Location

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

University Hospital - U.B.C. Site

Vancouver, British Columbia, V6T 2B5, Canada

Location

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada

Location

Familial Oncology Program

Kingston, Ontario, K7L 5P9, Canada

Location

Credit Valley Hospital

Mississauga, Ontario, L5M 2N1, Canada

Location

North York General Hospital, Ontario

North York, Ontario, M2E 1K1, Canada

Location

Ottawa Regional Cancer Centre

Ottawa, Ontario, K1H 1C4, Canada

Location

Northwestern Ontario Regional Cancer Care

Thunder Bay, Ontario, P7A 7T1, Canada

Location

Toronto Sunnybrook Regional Cancer Centre

Toronto, Ontario, M4N 3M5, Canada

Location

St. Michael's Hospital - Toronto

Toronto, Ontario, M5B 1W8, Canada

Location

Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada

Location

Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center

Toronto, Ontario, M5S 1B6, Canada

Location

CHUS-Hopital Fleurimont

Fleurimont, Quebec, J1H 5N4, Canada

Location

Hopital Charles Lemoyne

Greenfield Park, Quebec, J4V 2H1, Canada

Location

Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2L-4M1, Canada

Location

Royal Victoria Hospital - Montreal

Montreal, Quebec, H3A 1A1, Canada

Location

Montreal General Hospital

Montreal, Quebec, H3G 1A4, Canada

Location

Ville Marie Breast Center

Montreal, Quebec, H3G 1L5, Canada

Location

Jewish General Hospital - Montreal

Montreal, Quebec, H3T 1E2, Canada

Location

Hopital du Saint-Sacrement, Quebec

Québec, Quebec, G1S 4L8, Canada

Location

Centre Universitaire de Sante de L'Estrie

Sherbrooke, Quebec, J1H 5N4, Canada

Location

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada

Location

MBCCOP - San Juan

San Juan, 00927-5800, Puerto Rico

Location

Related Publications (14)

  • Cronin WM, Cecchini RS, Wickerham DL, et al.: Factors associated with participant adherence in the NSABP Study of Tamoxifen and Raloxifene (STAR). [Abstract] J Clin Oncol 26 (Suppl 15): A-6518, 2008.

    BACKGROUND
  • Land SR, Ritter MW, Costantino JP, Julian TB, Cronin WM, Haile SR, Wolmark N, Ganz PA. Compliance with patient-reported outcomes in multicenter clinical trials: methodologic and practical approaches. J Clin Oncol. 2007 Nov 10;25(32):5113-20. doi: 10.1200/JCO.2007.12.1749.

    PMID: 17991930BACKGROUND
  • Gradishar WJ, Cella D. Selective estrogen receptor modulators and prevention of invasive breast cancer. JAMA. 2006 Jun 21;295(23):2784-6. doi: 10.1001/jama.295.23.jed60037. Epub 2006 Jun 5. No abstract available.

    PMID: 16754726BACKGROUND
  • Vogel VG. The NSABP Study of Tamoxifen and Raloxifene (STAR) trial. Expert Rev Anticancer Ther. 2009 Jan;9(1):51-60. doi: 10.1586/14737140.9.1.51.

  • Wickerham DL, Costantino JP, Vogel VG, Cronin WM, Cecchini RS, Ford LG, Wolmark N. The use of tamoxifen and raloxifene for the prevention of breast cancer. Recent Results Cancer Res. 2009;181:113-9. doi: 10.1007/978-3-540-69297-3_12.

  • Ganz PA, Land SR, Wickerham DL, et al.: The Study of Tamoxifen and Raloxifene (STAR): Change in patient-reported outcomes (PROs) after the end of treatment. [Abstract] J Clin Oncol 25 (Suppl 18): A-1506, 2007.

    RESULT
  • Ganz PA, Land SR, Wickerham DL, et al.: The study of tamoxifen and raloxifene (STAR): first report of patient-reported outcomes (PROs) from the NSABP P-2 breast cancer prevention study. [Abstract] J Clin Oncol 24 (Suppl 18): A-LBA561, 2006.

    RESULT
  • Land SR, Wickerham DL, Costantino JP, Ritter MW, Vogel VG, Lee M, Pajon ER, Wade JL 3rd, Dakhil S, Lockhart JB Jr, Wolmark N, Ganz PA. Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006 Jun 21;295(23):2742-51. doi: 10.1001/jama.295.23.joc60075. Epub 2006 Jun 5.

  • Vogel VG, Costantino JP, Wickerham DL, et al.: The effects of tamoxifen versus raloxifene on the risk of developing noninvasive breast cancer in the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial. [Abstract] Breast Cancer Res Treat 100 (Suppl 1): A-33, S16, 2006.

    RESULT
  • Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER Jr, Wade JL 3rd, Robidoux A, Margolese RG, James J, Lippman SM, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N; National Surgical Adjuvant Breast and Bowel Project (NSABP). Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006 Jun 21;295(23):2727-41. doi: 10.1001/jama.295.23.joc60074. Epub 2006 Jun 5.

  • McCaskill-Stevens W, Wilson JW, Cook ED, Edwards CL, Gibson RV, McElwain DL, Figueroa-Moseley CD, Paskett ED, Roberson NL, Wickerham DL, Wolmark N. National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene trial: advancing the science of recruitment and breast cancer risk assessment in minority communities. Clin Trials. 2013 Apr;10(2):280-91. doi: 10.1177/1740774512470315. Epub 2013 Jan 18.

  • Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, Weissfeld JL, Wolmark N. Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prev Res (Phila). 2012 Apr;5(4):583-92. doi: 10.1158/1940-6207.CAPR-11-0482. Epub 2012 Feb 7.

  • Goetz MP, Schaid DJ, Wickerham DL, Safgren S, Mushiroda T, Kubo M, Batzler A, Costantino JP, Vogel VG, Paik S, Carlson EE, Flockhart DA, Wolmark N, Nakamura Y, Weinshilboum RM, Ingle JN, Ames MM. Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials. Clin Cancer Res. 2011 Nov 1;17(21):6944-51. doi: 10.1158/1078-0432.CCR-11-0860. Epub 2011 Aug 31.

  • Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER, Wade JL 3rd, Robidoux A, Margolese RG, James J, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N; National Surgical Adjuvant Breast and Bowel Project. Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer. Cancer Prev Res (Phila). 2010 Jun;3(6):696-706. doi: 10.1158/1940-6207.CAPR-10-0076. Epub 2010 Apr 19.

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Raloxifene HydrochlorideTamoxifen

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

StilbenesBenzylidene CompoundsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic Chemicals

Study Officials

  • Norman Wolmark, MD

    NSABP Foundation Inc

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 1, 1999

First Posted

January 27, 2003

Study Start

May 1, 1999

Primary Completion

December 1, 2005

Study Completion

August 1, 2012

Last Updated

October 6, 2015

Record last verified: 2015-10

Locations