Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
A Randomized Phase III Trial of Three Different Regimens of CPT-11 Plus 5-Fluorouracil and Leucovorin Compared to 5-Fluorouracil and Leucovorin in Patients With Advanced Adenocarcinoma of the Colon and Rectum
3 other identifiers
interventional
1,691
4 countries
466
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is most effective in treating advanced colorectal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of various combination chemotherapy regimens in treating patients who have advanced, recurrent, or metastatic colorectal cancer that cannot be treated with surgery or radiation therapy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 colorectal-cancer
Started Oct 1998
Typical duration for phase_3 colorectal-cancer
466 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 1998
CompletedFirst Submitted
Initial submission to the registry
November 1, 1999
CompletedFirst Posted
Study publicly available on registry
September 25, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2004
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2004
CompletedApril 29, 2020
April 1, 2020
6 years
November 1, 1999
April 28, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
time to progression
Up to 5 years
Secondary Outcomes (4)
overall survival
Up to 5 years
time to treatment failure
Up to 5 years
response rate
Up to 5 years
quality of life
Up to 5 years
Study Arms (3)
irinotecan + leucovorin + fluorouracil
EXPERIMENTALPatients receive irinotecan IV over 90 minutes followed by leucovorin calcium IV over 15 minutes and fluorouracil IV once a week for 4 weeks followed by 2 weeks of rest. Courses repeat every 6 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment. Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
oxaliplatin + leucovorin + fluorouracil
EXPERIMENTALPatients receive oxaliplatin IV over 2 hours on day 1 and leucovorin calcium IV over 2 hours plus fluorouracil IV over 22 hours on days 1 and 2. Courses repeat every 2 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment. Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
oxaliplatin + irinotecan
EXPERIMENTALPatients receive oxaliplatin IV over 2 hours and irinotecan IV over 30 minutes on day 1. Courses repeat every 3 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment. Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- Alliance for Clinical Trials in Oncologylead
- National Cancer Institute (NCI)collaborator
- NCIC Clinical Trials Groupcollaborator
Study Sites (466)
Veterans Affairs Medical Center - Birmingham
Birmingham, Alabama, 35233-1996, United States
MBCCOP - Gulf Coast
Mobile, Alabama, 36688, United States
CCOP - Greater Phoenix
Phoenix, Arizona, 85006-2726, United States
Veterans Affairs Medical Center - Phoenix (Hayden)
Phoenix, Arizona, 85012, United States
Mayo Clinic Hospital
Phoenix, Arizona, 85054-4502, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, 85259, United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723, United States
Arizona Cancer Center
Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205, United States
Cancer Center and Beckman Research Institute, City of Hope
Duarte, California, 91010-3000, United States
University of California San Diego Cancer Center
La Jolla, California, 92093-0658, United States
Veterans Affairs Medical Center - Long Beach
Long Beach, California, 90822, United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033-0804, United States
Veterans Affairs Medical Center - West Los Angeles
Los Angeles, California, 90073, United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781, United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553, United States
Community Hospital of the Monterey Peninsula
Monterey, California, 93940, United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305, United States
Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, 94304, United States
University of California Davis Medical Center
Sacramento, California, 95817, United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121, United States
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128, United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403, United States
Stanford University Medical Center
Stanford, California, 94305-5408, United States
David Grant Medical Center
Travis Air Force Base, California, 94535, United States
Columbia Medical Center of Aurora North Campus
Aurora, Colorado, 80011, United States
Penrose Cancer Center
Colorado Springs, Colorado, 80933, United States
University of Colorado Cancer Center
Denver, Colorado, 80010, United States
CCOP - Colorado Cancer Research Program, Inc.
Denver, Colorado, 80209-5031, United States
Porter Adventist Hospital
Denver, Colorado, 80210, United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218, United States
St. Joseph Hospital
Denver, Colorado, 80218, United States
HealthOne Rose Medical Center
Denver, Colorado, 80220, United States
Veterans Affairs Medical Center - Denver
Denver, Colorado, 80220, United States
Swedish Medical Center
Englewood, Colorado, 80110, United States
Rocky Mountain Cancer Centers - Northern Colorado
Fort Collins, Colorado, 80524-4038, United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
Poudre Valley Radiation Oncology
Fort Collins, Colorado, 80528, United States
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, 81004, United States
Bristol Hospital
Bristol, Connecticut, 06011-0977, United States
University of Connecticut Health Center
Farmington, Connecticut, 06360-7106, United States
St. Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
New Britain General Hospital
New Britain, Connecticut, 06050, United States
Lawrence and Memorial Hospital
New London, Connecticut, 06320, United States
William W. Backus Hospital
Norwich, Connecticut, 06360, United States
Northwestern Connecticut Oncology-Hematology Associates
Torrington, Connecticut, 06790, United States
CCOP - Christiana Care Health Services
Wilmington, Delaware, 19899, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000, United States
University of Florida - Gainesville
Gainesville, Florida, 32610-0277, United States
Baptist Regional Cancer Institute - Jacksonville
Jacksonville, Florida, 32207, United States
University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, 32209, United States
Mayo Clinic
Jacksonville, Florida, 32224, United States
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497, United States
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322, United States
Grady Memorial Hospital
Atlanta, Georgia, 30335, United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033, United States
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, 30905-5650, United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813, United States
BroMenn Lifecare Center
Bloomington, Illinois, 61701-3081, United States
St. Joseph's Hospital Medical Center
Bloomington, Illinois, 61701, United States
Graham Hospital Association
Canton, Illinois, 61520, United States
Memorial Hospital
Carthage, Illinois, 62321, United States
Hematology-Oncology Associates of Illinois
Chicago, Illinois, 60611-2998, United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, 60611-3013, United States
Hematology Oncology Associates of Illinois - Lake Shore Dr
Chicago, Illinois, 60611, United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, 60611, United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612, United States
Mercy Hospital and Medical Center
Chicago, Illinois, 60616, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470, United States
CCOP - Central Illinois
Decatur, Illinois, 62526, United States
Holy Family Medical Center
Des Plaines, Illinois, 60016, United States
St. Anthony's Memorial Hospital
Effingham, Illinois, 62401, United States
Northwest Oncology and Hematology, S.C.
Elk Grove Village, Illinois, 60007, United States
Eureka Hospital
Eureka, Illinois, 61530, United States
CCOP - Evanston
Evanston, Illinois, 60201, United States
Galesburg Clinic
Galesburg, Illinois, 61401, United States
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, 61401, United States
Galesburg Cottage Hospital
Galesburg, Illinois, 61402, United States
Glenbrook Hospital
Glenview, Illinois, 60025, United States
Ingalls Memorial Hospital
Harvey, Illinois, 60426, United States
Mason District Hospital
Havana, Illinois, 62644, United States
Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, 60035, United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141, United States
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, 60521, United States
Hopedale Medical Complex Hospital
Hopedale, Illinois, 61747, United States
Silver Cross Hospital
Joliet, Illinois, 60432, United States
Joliet Oncology/Hematology Associates, Ltd.
Joliet, Illinois, 60435, United States
Saint Joseph Medical Center
Joliet, Illinois, 60435, United States
Kewanee Hospital
Kewanee, Illinois, 61443, United States
Deerpath Medical Associates
Lake Forest, Illinois, 60045, United States
North Shore Oncology Hematology Associates
Libertyville, Illinois, 60048, United States
McDonough District Hospital
Macomb, Illinois, 61455, United States
Loyola University Medical Center
Maywood, Illinois, 60153, United States
Hematology/Oncology Associates of Illinois, LLC
Melrose Park, Illinois, 60160, United States
Mendota Community Hospital
Mendota, Illinois, 61342, United States
Trinity Medical Center
Moline, Illinois, 61265-1291, United States
Morris Hospital
Morris, Illinois, 60450, United States
BroMenn Regional Medical Center
Normal, Illinois, 61761, United States
Community Cancer Center
Normal, Illinois, 61761, United States
Hematology Oncology Associates of Illinois, LLC
Oak Park, Illinois, 60304, United States
Community Hospital of Ottawa
Ottawa, Illinois, 61350, United States
Pekin Hospital
Pekin, Illinois, 61554, United States
Illinois Oncology Research Association
Peoria, Illinois, 61602, United States
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, 61602, United States
Affiliated Urology Specialists
Peoria, Illinois, 61603, United States
Midwest Urological Group
Peoria, Illinois, 61603, United States
Peoria Urological Associates
Peoria, Illinois, 61614, United States
Proctor Hospital
Peoria, Illinois, 61614, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
Midwest Radiation Oncology Physicians
Peoria, Illinois, 61636, United States
St. Francis Medical Center
Peoria, Illinois, 61637, United States
Illinois Valley Community Hospital
Peru, Illinois, 61354, United States
St. James Hospital
Pontiac, Illinois, 61764, United States
Perry Memorial Hospital
Princeton, Illinois, 61356, United States
Trinity Medical Center
Rock Island, Illinois, 61201, United States
Swedish-American Health System
Rockford, Illinois, 61104-2315, United States
Sarah D. Culbertson Memorial Hospital
Rushville, Illinois, 62681, United States
Edward H. Kaplan MD and Associates
Skokie, Illinois, 60076, United States
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076, United States
Midwest Cancer Research Group, Inc.
Skokie, Illinois, 60077, United States
St. Margaret's Hospital
Spring Valley, Illinois, 61362, United States
Valley Cancer Center
Spring Valley, Illinois, 61362, United States
Carle Cancer Center
Urbana, Illinois, 61801, United States
Carle Foundation Hospital
Urbana, Illinois, 61801, United States
Therapy Associates Hematology/Oncology
Evansville, Indiana, 47715, United States
Oncology Institute of Greater Lafayette
Lafayette, Indiana, 47904, United States
McFarland Clinic, P.C.
Ames, Iowa, 50010, United States
William R. Bliss Cancer Center
Ames, Iowa, 50010, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
Saint Anthony Regional Hospital
Carroll, Iowa, 51401, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403, United States
Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
St. Luke's Hospital
Cedar Rapids, Iowa, 52406, United States
Alegent Health Southwest Iowa Medical Center
Council Bluffs, Iowa, 51503, United States
Des Moines General Hospital
Des Moines, Iowa, 50309, United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates
Des Moines, Iowa, 50314, United States
Mercy Hospital Medical Center
Des Moines, Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines, Iowa, 50316-2392, United States
Holden Comprehensive Cancer Center at The University of Iowa
Iowa City, Iowa, 52242-1009, United States
Mercy Cancer Center
Mason City, Iowa, 50401, United States
Community Memorial Hospital
Missouri Valley, Iowa, 51555-1199, United States
Burgess Health Center
Onawa, Iowa, 51040, United States
Oncology & Hematology of Ottumwa, PC
Ottumwa, Iowa, 52501, United States
Ottumwa Regional Health Center
Ottumwa, Iowa, 52501, United States
Siouxland Hematology-Oncology
Sioux City, Iowa, 51101-1733, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51101, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Cancer Center of Kansas - Arkansas City
Arkansas City, Kansas, 67005, United States
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801, United States
Radiation Oncology Center
Dodge City, Kansas, 67801, United States
Halstead Cancer Center of Kansas
Halstead, Kansas, 67056, United States
University of Kansas Medical Center
Kansas City, Kansas, 66160-7357, United States
Cancer Center of Kansas - Kingman
Kingman, Kansas, 67068, United States
Liberal Cancer Center of Kansas
Liberal, Kansas, 67901, United States
Cancer Center of Kansas - Newton
Newton, Kansas, 67114, United States
Pratt Cancer Center of Kansas
Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152, United States
Associates in Women's Health - Wichita
Wichita, Kansas, 67208, United States
Wichita Clinic Cancer Medicine Associates, P.A.
Wichita, Kansas, 67208, United States
CCOP - Wichita
Wichita, Kansas, 67214-3882, United States
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214, United States
Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218, United States
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156, United States
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40511-1093, United States
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0084, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112, United States
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932, United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130, United States
Veterans Affairs Medical Center - Togus
Togus, Maine, 04330, United States
Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
New England Medical Center Hospital
Boston, Massachusetts, 02111, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
Boston Medical Center
Boston, Massachusetts, 02118, United States
Faulkner Hospital
Jamaica Plain, Massachusetts, 02130, United States
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, 02130, United States
Lawrence Memorial Hospital of Medford/Hallmark Health Systems
Medford, Massachusetts, 02155, United States
Morton Hospital & Medical Center
Taunton, Massachusetts, 02780, United States
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, 01655, United States
Bixby Medical Center
Adrian, Michigan, 49221, United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105, United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0752, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379, United States
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
St. John Hospital and Medical Center
Detroit, Michigan, 48236, United States
Genesee Regional Medical Center
Flint, Michigan, 48503, United States
CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
Borgess Medical Center
Kalamazoo, Michigan, 49048-1666, United States
Sparrow Regional Cancer Center
Lansing, Michigan, 48909, United States
Office of E. Michael Lodish
Madison Heights, Michigan, 48071-3457, United States
Community Cancer Center of Monroe
Monroe, Michigan, 48162, United States
St. Mary's Medical Center
Saginaw, Michigan, 48601, United States
Balcueva Clinic
Saginaw, Michigan, 48602, United States
Providence Hospital - Southfield
Southfield, Michigan, 48075-9975, United States
St. John Macomb Hospital
Warren, Michigan, 48093-3494, United States
Alexandria Clinic
Alexandria, Minnesota, 56308, United States
Alexandria Radiation Oncology
Alexandria, Minnesota, 56308, United States
Brainerd Medical Center
Brainerd, Minnesota, 56401, United States
St. Joseph's Medical Center
Brainerd, Minnesota, 56401, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Duluth Clinic
Duluth, Minnesota, 55805, United States
Miller-Dwan Medical Center
Duluth, Minnesota, 55805, United States
St. Mary's/Duluth Clinic Health System
Duluth, Minnesota, 55805, United States
Fairview-Southdale Hospital
Edina, Minnesota, 55435, United States
Fergus Falls Medical Group
Fergus Falls, Minnesota, 56537, United States
Mercy/Unity Hospitals
Fridley, Minnesota, 55432, United States
Central Mesabi Medical Center
Hibbing, Minnesota, 55746, United States
Duluth Clinic - Hibbing
Hibbing, Minnesota, 55746, United States
Radiation Therapy Center
Hibbing, Minnesota, 55746, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
Meeker County Memorial Hospital
Litchfield, Minnesota, 55355, United States
St. John's Hospital
Maplewood, Minnesota, 55109, United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Virginia Piper Cancer Institute
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417, United States
North Memorial Research Center
Minneapolis, Minnesota, 55442-2900, United States
Fairview University Medical Center - Riverside Campus
Minneapolis, Minnesota, 55454-1395, United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
CentraCare Health Plaza
Saint Cloud, Minnesota, 56303, United States
St. Cloud Hospital
Saint Cloud, Minnesota, 56303, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Clinic
Saint Louis Park, Minnesota, 55416, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
Healtheast Cancer Care
Saint Paul, Minnesota, 55102, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505, United States
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216, United States
Keesler Medical Center - Keesler AFB
Keesler Air Force Base, Mississippi, 39534-2576, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201, United States
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, 65203, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807, United States
St. Louis University Health Sciences Center
St Louis, Missouri, 63110-0250, United States
Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
Fremont Area Medical Center
Fremont, Nebraska, 68025-2387, United States
Bryan LGH Medical Center
Lincoln, Nebraska, 68502-3780, United States
Prairie View Clinic
Lincoln, Nebraska, 68506-5247, United States
Bryan LGH Medical Center East
Lincoln, Nebraska, 68506, United States
Office of Susan Hansen, M.D.
Lincoln, Nebraska, 68506, United States
St. Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510, United States
Wedgewood Medical Center
Lincoln, Nebraska, 68510, United States
Southeast Nebraska Hematology
Lincoln, Nebraska, 68516, United States
Southeast Nebreska Hematology-Oncology Consultants, PC
Lincoln, Nebraska, 68516, United States
Williamsburg Radiation Oncology Center
Lincoln, Nebraska, 68516, United States
Veterans Affairs Medical Center - Omaha
Omaha, Nebraska, 68105, United States
Oncology Hematology West, P.C.
Omaha, Nebraska, 68114, United States
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, 68122, United States
Bergan Mercy Medical Center
Omaha, Nebraska, 68124, United States
Creighton University Cancer Center
Omaha, Nebraska, 68131-2197, United States
St. Joseph Hospital
Omaha, Nebraska, 68131-2197, United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198-3330, United States
Alegent Health-Midlands Community Hospital
Papillion, Nebraska, 68046-4194, United States
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002, United States
Center for Cancer And Hematologic Disease
Cherry Hill, New Jersey, 08046, United States
Trinitas Hospital - Jersey Street Campus
Elizabeth, New Jersey, 07201, United States
Hunterdon Regional Cancer Center
Flemington, New Jersey, 08822, United States
South Jersey Regional Cancer Center
Millville, New Jersey, 08332, United States
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly, New Jersey, 08060, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
Riverview Medical Center - Booker Cancer Center
Red Bank, New Jersey, 07701, United States
St. Francis Medical Center
Trenton, New Jersey, 08629, United States
Southern Oncology-Hematology Associates, P.A.
Vineland, New Jersey, 08360, United States
Comprehensive Cancer and Hematology Associates
Voorhees Township, New Jersey, 08043, United States
Burlington County Hematology Oncology Association, P.A.
Willingboro, New Jersey, 08046, United States
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138, United States
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131, United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215, United States
Mary Imogene Bassett Hospital
Cooperstown, New York, 13326, United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030, United States
Schneider Children's Hospital at North Shore
Manhasset, New York, 11030, United States
Veterans Affairs Medical Center - New York
New York, New York, 10010, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, 10016, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021, United States
New York Presbyterian Hospital - Cornell Campus
New York, New York, 10021, United States
Mount Sinai Medical Center, NY
New York, New York, 10029, United States
Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
Rochester General Hospital
Rochester, New York, 14621, United States
State University of New York - Upstate Medical University
Syracuse, New York, 13210, United States
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217, United States
Albert Einstein Comprehensive Cancer Center
The Bronx, New York, 10461, United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295, United States
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina, 27104-4241, United States
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1082, United States
Bismarck Cancer Center
Bismarck, North Dakota, 58501-4445, United States
Medcenter One Health System
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, 58501, United States
St. Alexius Medical Center
Bismarck, North Dakota, 58502, United States
CCOP - Merit Care Hospital
Fargo, North Dakota, 58122, United States
Meritcare Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
Altru Health Systems
Grand Forks, North Dakota, 58201, United States
Altru Cancer Center
Grand Forks, North Dakota, 58206, United States
Akron City Hospital
Akron, Ohio, 44309, United States
Wood County Oncology Center
Bowling Green, Ohio, 43402, United States
Mercy Ireland Cancer Center
Canton, Ohio, 44708, United States
Aultman Cancer Center
Canton, Ohio, 44710, United States
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288, United States
Barrett Cancer Center, The University Hospital
Cincinnati, Ohio, 45267-0502, United States
Ireland Cancer Center
Cleveland, Ohio, 44106-5065, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
CCOP - Columbus
Columbus, Ohio, 43206, United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240, United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428, United States
Woman Wise Blanchard Valley Regional Health Center
Findlay, Ohio, 45840, United States
Fremont Memorial Hospital
Fremont, Ohio, 43420, United States
Office of Sharon Cole, M.D.
Kenton, Ohio, 43326, United States
CCOP - Dayton
Kettering, Ohio, 45429, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
North West Ohio Oncology Center
Maumee, Ohio, 43537, United States
Saint Luke's Hospital
Maumee, Ohio, 43537, United States
St. Charles Hospital
Oregon, Ohio, 43616, United States
Firelands Regional Medical Center
Sandusky, Ohio, 44870, United States
North Coast Cancer Care, Inc.
Sandusky, Ohio, 44870, United States
Flower Hospital - Pro Medica Health System
Sylvania, Ohio, 43560, United States
Riverside Hospital
Toledo, Ohio, 43604, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical College of Ohio Hospital
Toledo, Ohio, 43614-0008, United States
MCO Cancer Institute
Toledo, Ohio, 43614, United States
Haematology-Oncology Associates, Inc.
Toledo, Ohio, 43623-4474, United States
Toledo Clinic, Inc.
Toledo, Ohio, 43623, United States
Fulton County Health Center
Wauseon, Ohio, 43567, United States
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, 73104, United States
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104, United States
CCOP - Oklahoma
Tulsa, Oklahoma, 74136, United States
Oregon Cancer Center
Portland, Oregon, 97201-3098, United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207, United States
CCOP - Columbia River Program
Portland, Oregon, 97213, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, 18103, United States
Muhlenberg Hospital Center
Bethlehem, Pennsylvania, 18017, United States
Marion Community Hospital
Carbondale, Pennsylvania, 18407, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-2001, United States
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, 19026, United States
DuBois Regional Medical Center
DuBois, Pennsylvania, 15801-0447, United States
UPMC Horizon
Greenville, Pennsylvania, 16125, United States
Pinnacle Health Hospitals
Harrisburg, Pennsylvania, 17105-8700, United States
Wayne Memorial Hospital
Honesdale, Pennsylvania, 18431-1498, United States
UPCI @ UPMC Lee Hospital
Johnstown, Pennsylvania, 15901, United States
Conemaugh Memorial Hospital
Johnstown, Pennsylvania, 15905, United States
Armstrong County Memorial Hospital
Kittanning, Pennsylvania, 16201-8808, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604-3555, United States
Saint Mary Regional Center
Langhorne, Pennsylvania, 19047, United States
Latrobe Area Hospital
Latrobe, Pennsylvania, 15650, United States
Central Pennsylvania Hematology and Medical Oncology Associates
Lemoyne, Pennsylvania, 17043, United States
Hahnemann University Hospital
Philadelphia, Pennsylvania, 19102-1192, United States
University of Pennsylvania Cancer Center
Philadelphia, Pennsylvania, 19104-4283, United States
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, 19141, United States
Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213-3180, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
UPMC/Passavant Hospital
Pittsburgh, Pennsylvania, 15237, United States
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, 19464, United States
Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052, United States
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, 18501, United States
Moses Taylor Hospital
Scranton, Pennsylvania, 18510, United States
Scranton Hematology-Oncology
Scranton, Pennsylvania, 18510, United States
Geisinger Medical Group
State College, Pennsylvania, 16801, United States
Chester County Hospital
West Chester, Pennsylvania, 19380, United States
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57709, United States
Sioux Valley Clinic
Sioux Falls, South Dakota, 57104, United States
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, 57105-1080, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Sioux Valley Hospital
Sioux Falls, South Dakota, 57117, United States
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, 38103, United States
Veterans Affairs Medical Center - Memphis
Memphis, Tennessee, 38104, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
University of Texas Medical Branch
Galveston, Texas, 77555-0209, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78284-7811, United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78284, United States
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148, United States
Vermont Cancer Center
Burlington, Vermont, 05401-3498, United States
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009, United States
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, 23249, United States
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037, United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101, United States
Swedish Cancer Institute
Seattle, Washington, 98104, United States
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108, United States
CCOP - Northwest
Tacoma, Washington, 98405-0986, United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000, United States
Fox Valley Hematology and Oncology
Appleton, Wisconsin, 54911, United States
Memorial Medical Center
Ashland, Wisconsin, 54806, United States
Luther Hospital
Eau Claire, Wisconsin, 54703, United States
Midelfort Clinic
Eau Claire, Wisconsin, 54703, United States
St. Vincent Hospital
Green Bay, Wisconsin, 54307-3508, United States
Franciscan Skemp Healthcare
La Crosse, Wisconsin, 54601-4796, United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
Veterans Affairs Medical Center - Madison
Madison, Wisconsin, 53705, United States
Dean Medical Center
Madison, Wisconsin, 53715, United States
Meriter Hospital
Madison, Wisconsin, 53715, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164, United States
CCOP - Marshfield Medical Research and Education Foundation
Marshfield, Wisconsin, 54449, United States
Aurora Sinai Samaritan Medical Center
Milwaukee, Wisconsin, 53201-0342, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, 53295, United States
Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066, United States
Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188, United States
UW Cancer Center Wausau Hospital
Wausau, Wisconsin, 54401, United States
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Cancer Agency - Centre for the Southern Interior
Kelowna, British Columbia, V1Y 5L3, Canada
Nanaimo Cancer Clinic
Nanaimo, British Columbia, V9S 2B7, Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2, Canada
British Columbia Cancer Agency
Vancouver, British Columbia, V5Z 4E6, Canada
British Columbia Cancer Agency - Vancouver Island Cancer Centre
Victoria, British Columbia, V8R 6V5, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
Nova Scotia Cancer Centre
Halifax, Nova Scotia, B3H 1V7, Canada
William Osler Health Centre
Brampton, Ontario, L6W 2Z8, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury
Greater Sudbury, Ontario, P3E 5J1, Canada
Cancer Care Ontario-London Regional Cancer Centre
London, Ontario, N6A 4L6, Canada
Trillium Health Centre
Mississauga, Ontario, L5B 1B8, Canada
Credit Valley Hospital
Mississauga, Ontario, L5M 2N1, Canada
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P9, Canada
Peterborough Oncology Clinic
Peterborough, Ontario, K9H 7B6, Canada
Algoma District Medical Group
Sault Ste. Marie, Ontario, P6B 1Y5, Canada
Hotel Dieu Health Sciences Hospital - Niagara
St. Catharines, Ontario, L2R 5K3, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, P7A 7T1, Canada
Mount Sinai Hospital - Toronto
Toronto, Ontario, M5G 1X5, Canada
Saint Joseph's Health Centre - Toronto
Toronto, Ontario, M6R 1B5, Canada
Humber River Regional Hospital
Weston, Ontario, M9N 1N8, Canada
Queen Elizabeth Hospital, PEI
Charlottetown, Prince Edward Island, C1A 8T5, Canada
Hopital Charles Lemoyne
Greenfield Park, Quebec, J4V 2H1, Canada
Maisonneuve-Rosemont Hospital
Montreal, Quebec, H1T 2M4, Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2L-4M1, Canada
CHUM Hopital Saint-Luc
Montreal, Quebec, H2X 3J4, Canada
L'Hopital Laval
Ste-Foy, Quebec, G1V 4G5, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
Pasqua Hospital
Regina, Saskatchewan, S4T 7T1, Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
Lions Gate Hospital
North Vancouver, V7L 2P9, Canada
Centro Mamografia Hospital Oncologico
Hato Rey, 00919-1811, Puerto Rico
Veterans Affairs Medical Center - San Juan
San Juan, 00927-5800, Puerto Rico
San Juan City Hospital
San Juan, 00936-7344, Puerto Rico
Medical Oncology Centre of Rosebank
Johannesburg, 2193, South Africa
Pretoria Academic Hospitals
Pretoria, 0001, South Africa
Related Publications (28)
Franko J, Shi Q, Goldman CD, Pockaj BA, Nelson GD, Goldberg RM, Pitot HC, Grothey A, Alberts SR, Sargent DJ. Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase III trials N9741 and N9841. J Clin Oncol. 2012 Jan 20;30(3):263-7. doi: 10.1200/JCO.2011.37.1039. Epub 2011 Dec 12.
PMID: 22162570BACKGROUNDAn MW, Mandrekar SJ, Branda ME, Hillman SL, Adjei AA, Pitot HC, Goldberg RM, Sargent DJ. Comparison of continuous versus categorical tumor measurement-based metrics to predict overall survival in cancer treatment trials. Clin Cancer Res. 2011 Oct 15;17(20):6592-9. doi: 10.1158/1078-0432.CCR-11-0822. Epub 2011 Aug 31.
PMID: 21880789BACKGROUNDCampbell ME, Mandrekar SJ, Hillman SL, et al.: What is the added value of actual tumor measurements (TM) in predicting overall survival (OS)? The North Central Cancer Treatment Group (NCCTG) findings. [Abstract] J Clin Oncol 26 (Suppl 15): A-6520, 2008.
BACKGROUNDGrothey A, Hedrick EE, Mass RD, Sarkar S, Suzuki S, Ramanathan RK, Hurwitz HI, Goldberg RM, Sargent DJ. Response-independent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107. J Clin Oncol. 2008 Jan 10;26(2):183-9. doi: 10.1200/JCO.2007.13.8099.
PMID: 18182660BACKGROUNDGrothey A, Hedrick EE, Mass RD, et al.: Response rate using conventional criteria is a poor surrogate for clinical benefit on progression-free (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC): a comparative analysis of N9741 and AVF2107. [Abstract] J Clin Oncol 24 (Suppl 18): A-3516, 2006.
BACKGROUNDGoldberg R. Oxaliplatin in colorectal cancer: current studies. Oncology (Williston Park). 2000 Dec;14(12 Suppl 11):42-7.
PMID: 11204663BACKGROUNDHeun JM, Grothey A, Branda ME, Goldberg RM, Sargent DJ. Tumor status at 12 weeks predicts survival in advanced colorectal cancer: findings from NCCTG N9741. Oncologist. 2011;16(6):859-67. doi: 10.1634/theoncologist.2011-0064. Epub 2011 May 31.
PMID: 21632455RESULTNg K, Sargent DJ, Goldberg RM, Meyerhardt JA, Green EM, Pitot HC, Hollis BW, Pollak MN, Fuchs CS. Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741. J Clin Oncol. 2011 Apr 20;29(12):1599-606. doi: 10.1200/JCO.2010.31.7255. Epub 2011 Mar 21.
PMID: 21422438RESULTGoldberg RM, Sargent DJ, McLeod H. Leveraging learning from a phase III colorectal cancer clinical trial: outcomes, methodology, meta-analysis and pharmacogenetics. Trans Am Clin Climatol Assoc. 2010;121:21-32; discussion 32-3.
PMID: 20697547RESULTMcLeod HL, Sargent DJ, Marsh S, Green EM, King CR, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Thibodeau SN, Grothey A, Morton RF, Goldberg RM. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. J Clin Oncol. 2010 Jul 10;28(20):3227-33. doi: 10.1200/JCO.2009.21.7943. Epub 2010 Jun 7.
PMID: 20530282RESULTGoldberg RM, Sargent DJ, Morton RF, Green E, Sanoff HK, McLeod H, Buckner J. NCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial. Oncologist. 2009 Oct;14(10):970-8. doi: 10.1634/theoncologist.2009-0175. Epub 2009 Oct 14.
PMID: 19828593RESULTSanoff HK, Sargent DJ, Green EM, McLeod HL, Goldberg RM. Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial. J Clin Oncol. 2009 Sep 1;27(25):4109-15. doi: 10.1200/JCO.2009.21.9527. Epub 2009 Jul 27.
PMID: 19636001RESULTFuchs CS, Goldberg RM, Sargent DJ, Meyerhardt JA, Wolpin BM, Green EM, Pitot HC, Pollak M. Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. Clin Cancer Res. 2008 Dec 15;14(24):8263-9. doi: 10.1158/1078-0432.CCR-08-0480. Epub 2008 Dec 10.
PMID: 19073970RESULTSanoff HK, Sargent DJ, Campbell ME, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Goldberg RM. Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. J Clin Oncol. 2008 Dec 10;26(35):5721-7. doi: 10.1200/JCO.2008.17.7147. Epub 2008 Nov 10.
PMID: 19001325RESULTSargent DJ, Campbell M, Grothey A, et al.: Overall and 12 week tumor response versus actual tumor measurements as predictors of overall survival (OS) in advanced colorectal cancer (ACRC): findings from NCCTG N9741. [Abstract] American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium, 25-27 January 2008, Orlando, FL. A-446, 2008.
RESULTDy GK, Krook JE, Green EM, Sargent DJ, Delaunoit T, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pockaj BA, Sticca RP, Alberts SR, Pitot HC 4th, Goldberg RM; Intergroup N9741. Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741. J Clin Oncol. 2007 Aug 10;25(23):3469-74. doi: 10.1200/JCO.2007.10.7128.
PMID: 17687151RESULTGrothey A, Sargent DJ, Campbell ME, et al.: Waterfall plots provide detailed information on magnitude of response to conventional chemotherapy in colorectal cancer: lessons learned from N9741. [Abstract] American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium, 19 -21 January 2007, Orlando, Florida A-337, 2007.
RESULTGoldberg RM, McLeod HL, Sargent DJ, et al.: Genetic polymorphisms, toxicity, and response rate in African Americans (AA) with metastatic colorectal cancer (MCRC) compared to Caucasians (C) when treated with IFL, FOLFOX or IROX in Intergroup N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3503, 2006.
RESULTGoldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Alberts S. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Trial. J Clin Oncol. 2006 Jul 20;24(21):3347-53. doi: 10.1200/JCO.2006.06.1317.
PMID: 16849748RESULTMcLeod HL, Parodi L, Sargent DJ, et al.: UGT1A1*28, toxicity and outcome in advanced colorectal cancer: results from trial N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3520, 2006.
RESULTDelaunoit T, Alberts SR, Sargent DJ, Green E, Goldberg RM, Krook J, Fuchs C, Ramanathan RK, Williamson SK, Morton RF, Findlay BP. Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741. Ann Oncol. 2005 Mar;16(3):425-9. doi: 10.1093/annonc/mdi092. Epub 2005 Jan 27.
PMID: 15677624RESULTDy GK, Krook J, Green E, et al.: Impact of complete response to chemotherapy on overall survival (OS) in advanced colorectal cancer (CRC): results from Intergroup N9741. [Abstract] American Society of Clinical Oncology 2005 Gastrointestinal Cancers Symposium, 27-29 January 2005, Miami, Florida. A-185, 2005.
RESULTDelaunoit T, Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Findlay BP, Thomas SP, Salim M, Schaefer PL, Stella PJ, Green E, Mailliard JA. Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin: results from Intergroup Trial N9741. Cancer. 2004 Nov 15;101(10):2170-6. doi: 10.1002/cncr.20594.
PMID: 15470715RESULTGoldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Alberts SR. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004 Jan 1;22(1):23-30. doi: 10.1200/JCO.2004.09.046. Epub 2003 Dec 9.
PMID: 14665611RESULTGoldberg RM, Morton RF, Sargent DJ, et al.: N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-1009, 252, 2003.
RESULTGoldberg RM, Morton RF, Sargent D, et al.: N9741: oxaliplatin (oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Initial toxicity and response data from a GI Intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-511, 2002.
RESULTMorton RF, Goldberg RM, Sargent DJ, et al.: Oxaliplatin (OXAL) or CPT-11 Combined with 5FU/Leucovorin (LV) in Advanced Colorectal Cancer (CRC): an NCCTG/CALGB Study. [Abstract] Proceedings of the American Society of Clinical Oncology 20: A-495, 2001.
RESULTYuan C, Renfro L, Ambadwar PB, Ou FS, McLeod HL, Innocenti F, Meyerhardt JA, Wolpin BM, Goldberg RM, Grothey A, Fuchs CS, Ng K. Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D3 levels and survival among patients with metastatic colorectal cancer. Cancer Causes Control. 2019 Jul;30(7):757-765. doi: 10.1007/s10552-019-01183-1. Epub 2019 May 18.
PMID: 31104167DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Henry C. Pitot, MD
Mayo Clinic
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 1, 1999
First Posted
September 25, 2003
Study Start
October 1, 1998
Primary Completion
October 1, 2004
Study Completion
October 1, 2004
Last Updated
April 29, 2020
Record last verified: 2020-04