Immune System Related Kidney Disease

NCT00001979 | Recruiting

• 2 other identifiers: 92015692-DK-0156
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders. This study will allow researchers to admit and follow patients suffering from autoimmune diseases of the kidney. It will attempt to provide information about the causes and specific abnormalities associated with autoimmune kidney disease. Patients with kidney disease as a result of their immune system, and patients with diseases of the immune system who may later develop kidney disease, will be potential subjects for this study. Patients will undergo a history and physical examination, and standard laboratory test to more closely understand the causes, signs, symptoms, and responses to medication of these diseases. Based on these evaluations the patients may qualify as candidates for other experimental studies. At any time these patients may be asked to submit blood or urine samples for further research.

Conditions

Kidney Disease; Nephrotic Syndrome

Keywords

Kidney Disease; Chronic Kidney Disease; Natural History

Outcome Measures

Primary Outcomes (1)

• Provision of biospecimens

  Patients with autoimmune diseases for whom there are no current experimental treatment protocols can be admitted for study and follow-up; they will provide a ready pool of candidates who can be asked to provide blood specimens for ongoing laboratory studies.

  ongoing

Study Arms (1)

Patients

Patients with known or suspected immunologically-mediated kidney diseases or immunologically-mediated diseases with potential for kidney disease.

Eligibility Criteria

• Age: 10 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with known or suspected immunologically-mediated kidney diseases, including but not limited to, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with other systemic or connective tissue disorders, or immunologically-mediated diseases with the potential for kidney disease.@@@

You may qualify if:

• In order to be eligible to participate in this study, a participant must meet all of the following criteria:
• Adults \>= 18 years of age and children 10-17 years of age
• Participants with
• known, proven, or suspected immunologically-mediated kidney diseases, including but not limited to nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with other systemic or connective tissue disorders, OR
• immunologically-mediated diseases with the potential for kidney disease.
• Ability of the participant or guardian to understand and the willingness of the participant or guardian to provide written informed consent.

You may not qualify if:

• An individual who meets any of the following criteria will be excluded from participation in this study:
• Concomitant medical problems which would confound the interpretation of studies of the immunologic kidney disorder.
• Concomitant medical, surgical, or other conditions for which inadequate facilities or funds are available to support their care at the NIH.

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

RECRUITING

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Conditions

Kidney Diseases; Nephrotic Syndrome; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Nephrosis; Renal Insufficiency; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Meryl A Waldman, M.D.

  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Meryl A Waldman, M.D.

CONTACT

(301) 451-6990; waldmanm@mail.nih.gov

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2000
• First Posted: January 21, 2000
• Study Start: June 25, 1992
• Last Updated: April 29, 2026

Record last verified: 2026-04-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)