NCT00001553

Brief Summary

Researchers have been interested in the changes associated with motor function in humans after suffering a stroke. Presently, the mechanism by which a person recovers motor function following a stroke is poorly understood. There is little information available about the areas of the brain involved in the recovery of limb function. Recently, a new set of techniques have been developed that may be useful for reducing the physical impairment often associated with strokes. The best way to identify the areas of the brain associated with regaining function is to test patients before, during, and after function is regained. This study will compare two therapies and determine which is better at improving recovery of motor function. The first technique involves immobilizing the functional limb and actively training the affected dysfunctional limb. The second technique involves no immobilization, and passive movement of the affected limb. Results from this study will indicate which of the two therapies is better at improving motor function. Additional diagnostic tests will help to identify changes in brain function associated with recovered use of affected limbs.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started May 1996

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 1996

Completed
3.5 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
1.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2001

Completed
1.8 years until next milestone

First Posted

Study publicly available on registry

December 10, 2002

Completed
Last Updated

March 4, 2008

Status Verified

April 1, 2000

First QC Date

November 3, 1999

Last Update Submit

March 3, 2008

Conditions

Cerebrovascular Accident

Keywords

PlasticityRecoveryStrokeUseCortico-subcortical Stroke

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Patients with stroke more than 1 year before testing. Patients with right cortico-subcortical strokes will be included.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Aram DM, Rose DF, Rekate HL, Whitaker HA. Acquired capsular/striatal aphasia in childhood. Arch Neurol. 1983 Oct;40(10):614-7. doi: 10.1001/archneur.1983.04050090050007.

    PMID: 6193770BACKGROUND

  • Bowers D, Heilman KM, Satz P, Altman A. Simultaneous performance on verbal, nonverbal and motor tasks by right-handed adults. Cortex. 1978 Dec;14(4):540-56. doi: 10.1016/s0010-9452(78)80029-x.

    PMID: 738063BACKGROUND

  • Brown JW, Leader BJ, Blum CS. Hemiplegic writing in severe aphasia. Brain Lang. 1983 Jul;19(2):204-15. doi: 10.1016/0093-934x(83)90065-2.

    PMID: 6192867BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

December 10, 2002

Study Start

May 1, 1996

Study Completion

March 1, 2001

Last Updated

March 4, 2008

Record last verified: 2000-04

Locations

US(1)