NCT00001552

Completed

Characteristics of Idiopathic Familial Voice Disorders

National Institute of Neurological Disorders and Stroke (NINDS)Source

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Other study identifiers

Sponsor study identifier

960089

Secondary identifiers

96-N-0089

Study Type

observational

Reported enrollment (type unavailable)

270

Locations

2 countries

Sites

4

Timeline

Study Start

May 22, 1996

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

November 13, 2009

Actual (reported)

Study Completion

Not reported

Date not reported

Brief Summary

The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions;

1.Spasmodic dysphonia
2.Vocal fold paralysis

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Reported enrollment (type unavailable): 270 participants
Study completion date: Not reported
Date not reported
Listed locations: 2 countries · 4 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
May 22, 1996
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
November 3, 1999
Actual (reported)
First Posted
November 4, 1999
Actual (reported)
Primary Completion
November 13, 2009
Actual (reported)

Last Updated: July 2, 2017
Status Verified: November 13, 2009
Last Update Submitted: June 30, 2017

Conditions

Laryngeal Disease Spastic Dysphonia Voice Disorder

Keywords

Spasmodic DysphoniaPedigreeVocal Fold ParalysisVoice Disorder

Eligibility Criteria

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

Symptoms present during speech and not apparent at rest,
Symptoms less evident during whisper, singing or falsetto.
Symptoms become worse with prolonged speaking, practice or anxiety.
Reflexive and emotional aspects of voice function are unaffected, such as coughing, laughter or crying.

You may not qualify if:

Sponsors & Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)
NIHlead

Study Sites (4)

University of Iowa

Iowa City, Iowa, 52242, United States

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Kennedy-Galton Centre Medical & Community Genetics

Harrow, United Kingdom

Institute of Cancer Research

Sutton, United Kingdom

Related Publications (3)

Conway D, Bain PG, Warner TT, Davis MB, Findley LJ, Thompson PD, Marsden CD, Harding AE. Linkage analysis with chromosome 9 markers in hereditary essential tremor. Mov Disord. 1993 Jul;8(3):374-6. doi: 10.1002/mds.870080324.
PMID: 8341306BACKGROUND
Durr A, Stevanin G, Jedynak CP, Penet C, Agid Y, Brice A. Familial essential tremor and idiopathic torsion dystonia are different genetic entities. Neurology. 1993 Nov;43(11):2212-4. doi: 10.1212/wnl.43.11.2212.
PMID: 8232931BACKGROUND

MeSH Terms

Conditions

Laryngeal DiseasesDysphoniaVoice Disorders

Condition Hierarchy (Ancestors)

Respiratory Tract DiseasesOtorhinolaryngologic DiseasesNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type: observational
Sponsor Type: NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

November 4, 1999

Study Start

May 22, 1996

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

November 13, 2009

Actual (reported)

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Any patient with a history of airway obstruction will be excluded from the study.

Structural abnormalities affecting the larynx such as vocal fold nodules, polyps, carcinoma, cysts, contact ulcers, or inflammation (laryngitis).

Reduction in vocal fold movement range during non-speech tasks such as whistling which would suggest either paralysis or paresis, joint abnormality or neoplasm.

No smokers or tobacco users will be included in the study.

Subjects with history of a psychiatric disorder, under the care of a psychiatrist, or on medications for treatment of a psychiatric disorder will be excluded from the study. Examples of psychiatric disorders to be excluded are: somatoform disorders, conversion disorders, currently under treatment for a major depression, or a history of schizophrenia or a bipolar disorder. However, a history of a previous episode of a minor reactive depression would not exclude a person from participation.

Contact the study team to confirm eligibility.

Dyck PJ, Litchy WJ, Minnerath S, Bird TD, Chance PF, Schaid DJ, Aronson AE. Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis. Ann Neurol. 1994 May;35(5):608-15. doi: 10.1002/ana.410350515.

PMID: 8179305BACKGROUND

Last Updated

July 2, 2017

Record last verified: 2009-11-13

Source record

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Source: ClinicalTrials.gov.

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Registry identifier: NCT00001552
Data provider: ClinicalTrials.gov
Source updated: 2017-07-02
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:29:30 UTC

Locations

GB(2)US(2)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Conditions

Keywords

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (4)

Related Publications (3)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

Source record

Locations