Characteristics of Idiopathic Familial Voice Disorders
2 other identifiers
observational
270
2 countries
4
Brief Summary
The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions;
- 1.Spasmodic dysphonia
- 2.Vocal fold paralysis
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 22, 1996
CompletedFirst Submitted
Initial submission to the registry
November 3, 1999
CompletedFirst Posted
Study publicly available on registry
November 4, 1999
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 13, 2009
CompletedJuly 2, 2017
November 13, 2009
13.5 years
November 3, 1999
June 30, 2017
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- Symptoms present during speech and not apparent at rest,
- Symptoms less evident during whisper, singing or falsetto.
- Symptoms become worse with prolonged speaking, practice or anxiety.
- Reflexive and emotional aspects of voice function are unaffected, such as coughing, laughter or crying.
You may not qualify if:
- Any patient with a history of airway obstruction will be excluded from the study.
- Structural abnormalities affecting the larynx such as vocal fold nodules, polyps, carcinoma, cysts, contact ulcers, or inflammation (laryngitis).
- Reduction in vocal fold movement range during non-speech tasks such as whistling which would suggest either paralysis or paresis, joint abnormality or neoplasm.
- No smokers or tobacco users will be included in the study.
- Subjects with history of a psychiatric disorder, under the care of a psychiatrist, or on medications for treatment of a psychiatric disorder will be excluded from the study. Examples of psychiatric disorders to be excluded are: somatoform disorders, conversion disorders, currently under treatment for a major depression, or a history of schizophrenia or a bipolar disorder. However, a history of a previous episode of a minor reactive depression would not exclude a person from participation.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (4)
University of Iowa
Iowa City, Iowa, 52242, United States
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Kennedy-Galton Centre Medical & Community Genetics
Harrow, United Kingdom
Institute of Cancer Research
Sutton, United Kingdom
Related Publications (3)
Conway D, Bain PG, Warner TT, Davis MB, Findley LJ, Thompson PD, Marsden CD, Harding AE. Linkage analysis with chromosome 9 markers in hereditary essential tremor. Mov Disord. 1993 Jul;8(3):374-6. doi: 10.1002/mds.870080324.
PMID: 8341306BACKGROUNDDurr A, Stevanin G, Jedynak CP, Penet C, Agid Y, Brice A. Familial essential tremor and idiopathic torsion dystonia are different genetic entities. Neurology. 1993 Nov;43(11):2212-4. doi: 10.1212/wnl.43.11.2212.
PMID: 8232931BACKGROUNDDyck PJ, Litchy WJ, Minnerath S, Bird TD, Chance PF, Schaid DJ, Aronson AE. Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis. Ann Neurol. 1994 May;35(5):608-15. doi: 10.1002/ana.410350515.
PMID: 8179305BACKGROUND