Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease

NCT00001528 | Completed

• 2 other identifiers: 96003196-H-0031
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart. The lowered blood supply to the heart muscle may not cause symptoms immediately. However, as the heart pumps faster and harder the blood supply demand is increased. If blood flow is unable supply enough oxygen and nutrition to heart muscle patients can experience symptoms of chest pain and shortness of breath. Even after the heart slows down and demand for oxygen and nutrition is reduced, patients can still experience pain and abnormal heart function. The purpose of this study is to determine the changes in blood flow and the beating function of the heart during periods of increased demands (such as exercise) and shortly after stopping exercise. Blood flow to the heart will be measured by positron emission tomography (PET scan). The PET scan is a test where a small amount of radioactive water is injected into the bloodstream and pictures of the heart are taken by the special camera. This procedure allows researchers to measure blood flow to heart muscle. In order to measure nutrition (metabolism) of the heart muscle, researchers will use a radioactive substance similar to sugar (Fluorodeoxyglucose). Results of this study may provide important information about the activity and function of heart muscle after exercise in patients suffering from coronary artery disease.

Conditions

Healthy

Keywords

Coronary Artery Disease; Gated Blood Pool Tomography; Myocardial Blood Flow; Myocardial Stunning; Positron Emission Tomography

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Adult patients with greater than 50% stenosis in at least one major coronary artery. No significant valvular heart disease. No congenital heart disease. No myocardial disease unrelated to co-existing coronary artery disease. No severe angina where withdrawal of therapy would be dangerous. No recent unstable angina or myocardial infarction (less than 1 month). Not pregnant or breast feeding. No history of ventricular tachycardia or malignant arrhythmias. No history of active bronchospastic disease.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

National Heart, Lung and Blood Institute (NHLBI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (2)

• Kloner RA, Allen J, Cox TA, Zheng Y, Ruiz CE. Stunned left ventricular myocardium after exercise treadmill testing in coronary artery disease. Am J Cardiol. 1991 Aug 1;68(4):329-34. doi: 10.1016/0002-9149(91)90827-8.

  PMID: 1858675 BACKGROUND

• Camici P, Araujo LI, Spinks T, Lammertsma AA, Kaski JC, Shea MJ, Selwyn AP, Jones T, Maseri A. Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina. Circulation. 1986 Jul;74(1):81-8. doi: 10.1161/01.cir.74.1.81.

  PMID: 3486725 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease; Myocardial Stunning

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: December 10, 2002
• Study Start: February 1, 1996
• Study Completion: March 1, 2001
• Last Updated: March 4, 2008

Record last verified: 2000-04

Locations

US (1)