Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers

NCT00001459 | Completed

• 2 other identifiers: 95004895-H-0048
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart (microvascular heart disease), or damage to the heart muscle (hypertrophic cardiomyopathy) can cause myocardial ischemia. Any of theses three conditions can cause patients to experience chest pain and other symptoms as well as cause the heart to function improperly. In order to detect myocardial ischemia researchers can use tests to measure the movement of the walls of the heart. Walls receiving inadequate supplies of blood often move less and occasionally move in the opposite direction. Some of the tests may require patients to receive injections of radioactive tracers. The radioactive material acts to enhance 3 dimensional pictures of the heart and helps to identify areas of ischemia. The purpose of this study is to determine whether 3-dimensional imaging (tomography) with radioactive tracers can provide more important information about heart wall function than routine diagnostic tests.

Conditions

Cardiomyopathy, Hypertrophic; Coronary Disease; Healthy; Myocardial Ischemia; Syndrome X

Keywords

Gated Blood Pool; SPECT Scan; Coronary Artery Disease; Hypertrophic Cardiomyopathy; Microvascular Angina

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Patients with known coronary artery disease (obstruction of greater than or equal to 50% in at least one major coronary artery). Patients with hypertrophic cardiomyopathy. Patients with microvascular angina. No unstable angina. No hepatic or renal failure. Infective endocarditis No primary valvular disease. No congenital heart disease. No pregnant or breast feeding women.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

National Heart, Lung and Blood Institute (NHLBI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Faber TL, Stokely EM, Templeton GH, Akers MS, Parkey RW, Corbett JR. Quantification of three-dimensional left ventricular segmental wall motion and volumes from gated tomographic radionuclide ventriculograms. J Nucl Med. 1989 May;30(5):638-49.

  PMID: 2785584 BACKGROUND

• Corbett JR, Jansen DE, Lewis SE, Gabliani GI, Nicod P, Filipchuk NG, Redish GA, Akers MS, Wolfe CL, Rellas JS, et al. Tomographic gated blood pool radionuclide ventriculography: analysis of wall motion and left ventricular volumes in patients with coronary artery disease. J Am Coll Cardiol. 1985 Aug;6(2):349-58. doi: 10.1016/s0735-1097(85)80171-6.

  PMID: 2991357 BACKGROUND

• Borer JS, Kent KM, Bacharach SL, Green MV, Rosing DR, Seides SF, Epstein SE, Johnston GS. Sensitivity, specificity and predictive accuracy of radionuclide cineangiography during exercise in patients with coronary artery disease. Comparison with exercise electrocardiography. Circulation. 1979 Sep;60(3):572-80. doi: 10.1161/01.cir.60.3.572. No abstract available.

  PMID: 455620 BACKGROUND

MeSH Terms

Conditions

Cardiomyopathy, Hypertrophic; Coronary Disease; Myocardial Ischemia; Microvascular Angina; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Cardiomyopathies; Heart Diseases; Cardiovascular Diseases; Aortic Stenosis, Subvalvular; Aortic Valve Stenosis; Aortic Valve Disease; Heart Valve Diseases; Vascular Diseases; Angina Pectoris; Arteriosclerosis; Arterial Occlusive Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: December 10, 2002
• Study Start: January 1, 1995
• Study Completion: March 1, 2001
• Last Updated: March 4, 2008

Record last verified: 2000-01

Locations

US (1)