NCT00001414

Brief Summary

Previous research involving families, twins, and adoption all support the idea that there is a substantial heritable aspect to personality. The goal of this research study is to determine how genetics influence heritable personality traits. The work will focus on how genetics affect the chemical messengers which brain cells use to communicate with each other (neurotransmitters). The study involves collecting personality data and DNA samples from related individuals, primarily male siblings and female siblings, but also including parents. Genetic tests performed on these samples will continue to focus on variations in genes, which potentially effect brain neurotransmission. This research has the potential to advance knowledge of genetic influences on human behavior that may be relevant both to normal personality and to psychopathology.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,400

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 1994

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1994

Completed
5.6 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 4, 1999

Completed
2.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2002

Completed
Last Updated

March 4, 2008

Status Verified

June 1, 2002

First QC Date

November 3, 1999

Last Update Submit

March 3, 2008

Conditions

Mental Disorder

Keywords

Behavior GeneticsNormal PersonalityIntelligenceSiblingsSixteen Personality Factor QuestionnaireNEO-Personality Inventory (Revised)X-Chromosome

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Personality data and DNA samples will be collected from related individuals, primarily pairs of male and pairs of female siblings, but also including parents.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Ahern FM, Johnson RC, Wilson JR, McClearn GE, Vandenberg SG. Family resemblances in personality. Behav Genet. 1982 May;12(3):261-80. doi: 10.1007/BF01067847. No abstract available.

    PMID: 6889860BACKGROUND

  • Amos CI, Elston RC, Wilson AF, Bailey-Wilson JE. A more powerful robust sib-pair test of linkage for quantitative traits. Genet Epidemiol. 1989;6(3):435-49. doi: 10.1002/gepi.1370060306.

    PMID: 2753353BACKGROUND

  • Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet. 1996 Jan;12(1):81-4. doi: 10.1038/ng0196-81. No abstract available.

    PMID: 8528258BACKGROUND

MeSH Terms

Conditions

Mental Disorders

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

November 4, 1999

Study Start

April 1, 1994

Study Completion

June 1, 2002

Last Updated

March 4, 2008

Record last verified: 2002-06

Locations

US(1)