NCT00001413|Completed
Bone Mineral Density in Women With Major Depression
Bone Mineral Density in Patients With Major Depression With Melancholic and Atypical Features: Relation to Stress-System Neurohormonal Function
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Bone Mineral Density in Patients With Major Depression With Melancholic and Atypical Features: Relation to Stress-System Neurohormonal Function
Sponsor study identifier
Secondary identifiers
observational
585
1 country
1
Study Start
April 6, 1994
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
January 19, 2007
Date type not reportedThis date has not been verified as actual or estimated.
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than pre-menopausal women without depression. Although the mechanisms of BMD loss are unclear, researchers believe that individuals with depression have impaired calcium absorption. However, it is unknown whether the abnormal absorption is a result of depression or a side effect of the drugs used to treat it. This study will compare calcium absorption in women with depression and in healthy women without depression. Participants in this study will be given two non-radioactive calcium isotopes. One can be taken by mouth and the other must be injected. Participants will have the level of isotopes in their urine measured to estimate true fractional calcium absorption (TFCA). Participants may also have a dual X-ray absorptiometry (DEXA) scan to measure total body adiposity and lean body mass.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 19, 2007
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 6, 1994
Date type not reportedThis date has not been verified as actual or estimated.
November 3, 1999
Actual (reported)November 4, 1999
Actual (reported)January 19, 2007
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Mazess RB, Barden H, Ettinger M, Schultz E. Bone density of the radius, spine, and proximal femur in osteoporosis. J Bone Miner Res. 1988 Feb;3(1):13-8. doi: 10.1002/jbmr.5650030104.
First Submitted
November 3, 1999
First Posted
November 4, 1999
Study Start
April 6, 1994
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
January 19, 2007
Date type not reportedThis date has not been verified as actual or estimated.
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
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Last Updated
July 2, 2017
Record last verified: 2007-01-19
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Source: ClinicalTrials.gov.
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