Bone Mineral Density in Women With Major Depression

NCT00001413 | Completed

• 2 other identifiers: 94012194-M-0121
• Study Type: observational
• Target: 585
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than pre-menopausal women without depression. Although the mechanisms of BMD loss are unclear, researchers believe that individuals with depression have impaired calcium absorption. However, it is unknown whether the abnormal absorption is a result of depression or a side effect of the drugs used to treat it. This study will compare calcium absorption in women with depression and in healthy women without depression. Participants in this study will be given two non-radioactive calcium isotopes. One can be taken by mouth and the other must be injected. Participants will have the level of isotopes in their urine measured to estimate true fractional calcium absorption (TFCA). Participants may also have a dual X-ray absorptiometry (DEXA) scan to measure total body adiposity and lean body mass.

Conditions

Healthy; Involutional Depression; Osteoporosis

Keywords

Corticosteroids; Osteoporosis; Depression; DEXA Scan; Body Mass; Dual X-Ray; Energy Absorptiometry; Normal Volunteer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with Bipolar Disorder will be eligible if they meet the depressive episode criterion.

You may not qualify if:

• DEPRESSED SUBJECTS:
• Pregnant women will not be eligible to participate.
• Known medical causes of osteoporosis, other than depression.
• Current or past history of eating disorders, or schizophrenia, as per DSM-IV.
• Chronic use of oral or parenteral steroids (daily use for 3 months or longer).
• HEALTHY SUBJECTS:
• Pregnant women will not be eligible to participate.
• Known medical causes of osteoporosis.
• Any history of DSM-IV diagnosis, including depression, eating disorders, and alcohol or drug abuse.
• History or current evidence of any significant clinical or laboratory abnormalities.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Mazess RB, Barden H, Ettinger M, Schultz E. Bone density of the radius, spine, and proximal femur in osteoporosis. J Bone Miner Res. 1988 Feb;3(1):13-8. doi: 10.1002/jbmr.5650030104.

  PMID: 3213603 BACKGROUND

MeSH Terms

Conditions

Depressive Disorder, Major; Osteoporosis; Depression

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: April 6, 1994
• Study Completion: January 19, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-01-19

Locations

US (1)