Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia

NCT00001323 | Completed

• 2 other identifiers: 92026292-M-0262
• Study Type: observational
• Target: 810
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers. Participants in this study will undergo cognitive tests of attention, memory, attention. Participants with attention deficit hyperactivity disorder (ADHD), traumatic brain injury (TBI), bipolar disorder, and Alzheimer's disease (AD) will be compared with participants with schizophrenia. A group of healthy adults and children will undergo cognitive tests to further delineate the degree of impairment in schizophrenia and neurological disorder participants.

Conditions

Brain Injury; Dementia; Healthy; Mental Disorder; Schizophrenia

Keywords

Cognition; Neuropsychology; Neuropsychological Tests; Neurological Exam; Psychiatric; Attention; Schizophrenic; Schizoaffective; Working Memory; Memory

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse.
• Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections.
• Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public.

You may not qualify if:

• Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID.
• Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Goldberg TE, Weinberger DR, Berman KF, Pliskin NH, Podd MH. Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Arch Gen Psychiatry. 1987 Nov;44(11):1008-14. doi: 10.1001/archpsyc.1987.01800230088014.

  PMID: 3675128 BACKGROUND

• Seidman LJ. Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychol Bull. 1983 Sep;94(2):195-238. No abstract available.

  PMID: 6356196 BACKGROUND

• Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry. 1986 Feb;43(2):114-24. doi: 10.1001/archpsyc.1986.01800020020004.

  PMID: 3947207 BACKGROUND

MeSH Terms

Conditions

Brain Injuries; Dementia; Mental Disorders; Schizophrenia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Neurocognitive Disorders; Schizophrenia Spectrum and Other Psychotic Disorders

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: August 1, 1992
• Study Completion: August 1, 2005
• Last Updated: March 4, 2008

Record last verified: 2005-08

Locations

US (1)