Ultrasound Evaluation of Tongue Movements in Speech and Swallowing

NCT00001167 | Completed

• 2 other identifiers: 79010179-CC-0101
• Study Type: observational
• Target: 570
• Locations: 1 country
• Sites: 1

Brief Summary

This study will assess the use of ultrasound-a test that uses sound waves to produce images-as a diagnostic tool for evaluating speech and swallowing. The following categories of individuals may be eligible for this study: 1) healthy volunteers between 20 and 85 years old with normal speech and hearing, 2) patients 6 to 85 years old with developmental neurological deficits in speech or swallowing, and 3) patients with tumors of the oral cavity, pharynx or larynx being treated at the Greater Baltimore Medical Center. Participants will undergo a 30-minute speech and oral motion evaluation, in which they imitate sounds, words and oral movements while a speech pathologist evaluates their lip, tongue and palate movements. They may also be asked to drink a small amount of water for examination of swallowing function. For the ultrasound examination, a 3/4-inch transducer (device for transmitting and receiving sound waves) is placed under the participant's chin. While the transducer is in place, the subject 1) repeats sounds and a series of syllables in several sequences, 2) swallows three times with and without a small amount of water, and 3) swallows 3 teaspoons of non-fat pudding. The ultrasound images are recorded on tape for later analysis.

Conditions

Otorhinolaryngologic Disease; Otorhinolaryngologic Neoplasm; Pharyngeal Neoplasm; Polymyositis; Speech Disorder

Keywords

Dysphagia; Dysarthria; Tongue Motion; Xerostomia; Swallowing; Speech; Polymyositis; Speech Disorders; Oral-Facial Paralysis; Ultrasound

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Normal volunteers:
• Normal volunteers ages 21 to 85 may be asked to participate in a study of speech and swallowing utilizing a traditional clinical examination of oral-motor performance. If the subjects are without deficits in dental occlusion, speech articulation, tongue and lip strength, tongue and lip mobility, palatal function and oral sensation they will be asked to participate in an ultrasonic evaluation of tongue/hyoid interaction during swallowing and speech.
• Children will be included if they are referred with a medical condition that affects the oral pharyngeal phase of swallowing, voice production or laryngeal function and the investigator needs to evaluate functional performance and safety for oral feeding.
• Neurological Group:
• Subjects aged 6 to 85 with diagnosed developmental, neuromotor, systemic, genetic, neurologic, structural and post surgical dysfunction who have deficits in speech (dysarthria) and/or swallow (dysphagia) may be asked to participate in this study of ultrasonic imaging. Aging patients with and without dementia may also be studied. Patients with Post Polio Syndrome, Polymyositis, Dermatomyositis, Toricollis, Cerebellar Degeneration, Parkinson's disease, Progressive Supranuclear Palsy, ALS, Cystinosis, are among the conditions of interest. Subjects with complaints of oral dryness, and patients who have undergone mandibular and oral surgery may also be studied during swallowing.
• Oropharyngeal/Laryngeal Tumors:
• Patients will be seen who are enrolled in NCI and NIDCD protocols for head and neck tumors.

You may not qualify if:

• Normal Subjects:
• Hearing impairment reported (above 40 db, bilaterally)
• Dentures
• Oral Prosthesis
• Palatal surgery or other restorative dental surgery
• Radial neck dissection, glossectomy
• Tumor or masses in neck or tongue
• Cerebral vascular attack
• Stuttering
• Non-English speaker
• Childhood articulation impairment

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead

Study Sites (1)

Warren G. Magnuson Clinical Center (CC)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Sonies BC, Dalakas MC. Dysphagia in patients with the post-polio syndrome. N Engl J Med. 1991 Apr 25;324(17):1162-7. doi: 10.1056/NEJM199104253241703.

  PMID: 2011159 BACKGROUND

• Sonies BC, Ekman EF, Andersson HC, Adamson MD, Kaler SG, Markello TC, Gahl WA. Swallowing dysfunction in nephropathic cystinosis. N Engl J Med. 1990 Aug 30;323(9):565-70. doi: 10.1056/NEJM199008303230903.

  PMID: 2381441 BACKGROUND

• Shawker TH, Sonies B, Hall TE, Baum BF. Ultrasound analysis of tongue, hyoid, and larynx activity during swallowing. Invest Radiol. 1984 Mar-Apr;19(2):82-6. doi: 10.1097/00004424-198403000-00003.

  PMID: 6398320 BACKGROUND

MeSH Terms

Conditions

Otorhinolaryngologic Diseases; Otorhinolaryngologic Neoplasms; Pharyngeal Neoplasms; Polymyositis; Speech Disorders; Deglutition Disorders; Dysarthria; Xerostomia; Speech

Condition Hierarchy (Ancestors)

Head and Neck Neoplasms; Neoplasms by Site; Neoplasms; Pharyngeal Diseases; Stomatognathic Diseases; Myositis; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Articulation Disorders; Salivary Gland Diseases; Mouth Diseases; Verbal Behavior; Communication; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: August 1, 1979
• Study Completion: November 1, 2004
• Last Updated: March 4, 2008

Record last verified: 2004-11

Locations

US (1)