Dietary Effects on Lipoproteins and Thrombogenic Activity
DELTA
2 other identifiers
interventional
189
0 countries
N/A
Brief Summary
To evaluate the effects of carefully controlled diets on lipoproteins and clotting factors in different demographic groups.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_3 cardiovascular-diseases
Started Sep 1992
Shorter than P25 for phase_3 cardiovascular-diseases
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 1992
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 1995
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 1995
CompletedFirst Submitted
Initial submission to the registry
October 27, 1999
CompletedFirst Posted
Study publicly available on registry
October 28, 1999
CompletedFebruary 22, 2024
August 1, 2014
2.7 years
October 27, 1999
February 20, 2024
Conditions
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (12)
Ginsberg HN. New directions in dietary studies and heart disease: the National Heart, Lung and Blood Institute sponsored Multicenter Study of Diet Effects on Lipoproteins and Thrombogenic Activity. Adv Exp Med Biol. 1995;369:241-7. doi: 10.1007/978-1-4615-1957-7_23.
PMID: 7598013BACKGROUNDDennis BH, Stewart P, Wang CH, Champagne C, Windhauser M, Ershow A, Karmally W, Phillips K, Stewart K, Van Heel N, Farhat-Wood A, Kris-Etherton PM. Diet design for a multicenter controlled feeding trial: the DELTA program. Delta Research Group. J Am Diet Assoc. 1998 Jul;98(7):766-76. doi: 10.1016/s0002-8223(98)00173-4.
PMID: 9664917BACKGROUNDLefevre M, Ginsberg HN, Kris-Etherton PM, Elmer PJ, Stewart PW, Ershow A, Pearson TA, Roheim PS, Ramakrishnan R, Derr J, Gordon DJ, Reed R. ApoE genotype does not predict lipid response to changes in dietary saturated fatty acids in a heterogeneous normolipidemic population. The DELTA Research Group. Dietary Effects on Lipoproteins and Thrombogenic Activity. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2914-23. doi: 10.1161/01.atv.17.11.2914.
PMID: 9409276BACKGROUNDReed RG, Kris-Etherton P, Stewart PW, Pearson TA. Variation of lipids and lipoproteins in premenopausal women compared with men and postmenopausal women. DELTA (Dietary Effects on Lipoproteins and Thrombogenic Activity) Investigators. Metabolism. 2000 Sep;49(9):1101-5. doi: 10.1053/meta.2000.8603.
PMID: 11016887BACKGROUNDGinsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed R, Stewart K, Stewart P, Phillips K, Anderson N. Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1. Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):441-9. doi: 10.1161/01.atv.18.3.441.
PMID: 9514413BACKGROUNDPhillips KM, Tarrago-Trani MT, Grove TM, Grun I, Lugogo R, Harris RF, Stewart KK. Simplified gravimetric determination of total fat in food composites after chloroform-methanol extraction. Journal of American Oil Chemists' Society 74(2): 137-142, 1997.
BACKGROUNDMustad VA, Etherton TD, Cooper AD, Mastro AM, Pearson TA, Jonnalagadda SS, Kris-Etherton PM. Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women. J Lipid Res. 1997 Mar;38(3):459-68.
PMID: 9101427BACKGROUNDPhillips KM, Tarrago-Trani MT, Stewart KK. Phytosterol content of experimental diets differing in fatty acid composition. Food Chemistry 64(3): 415-422, 1999. https://www.sciencedirect.com/science/article/pii/S0308814698000909
BACKGROUNDBerglund L, Oliver EH, Fontanez N, Holleran S, Matthews K, Roheim PS, Ginsberg HN, Ramakrishnan R, Lefevre M. HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects. Am J Clin Nutr. 1999 Dec;70(6):992-1000. doi: 10.1093/ajcn/70.6.992.
PMID: 10584043BACKGROUNDKris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD. High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr. 1999 Dec;70(6):1009-15. doi: 10.1093/ajcn/70.6.1009.
PMID: 10584045BACKGROUNDAussel C, Fehlmann M. Effect of alpha-fetoprotein on arachidonic acid metabolism in a human T-cell line. Immunol Lett. 1987 Jan;14(2):133-7. doi: 10.1016/0165-2478(87)90092-7.
PMID: 2438210BACKGROUNDKris-Etherton PM, Stewart PW, Ginsberg HN, Tracy RP, Lefevre M, Elmer PJ, Berglund L, Ershow AG, Pearson TA, Ramakrishnan R, Holleran SF, Dennis BH, Champagne CM, Karmally W; DELTA Investigators. The Type and Amount of Dietary Fat Affect Plasma Factor VIIc, Fibrinogen, and PAI-1 in Healthy Individuals and Individuals at High Cardiovascular Disease Risk: 2 Randomized Controlled Trials. J Nutr. 2020 Aug 1;150(8):2089-2100. doi: 10.1093/jn/nxaa137.
PMID: 32492148DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
Patricia Elmer
University of Minnesota
Penny Kris-Etherton
Penn State University
Paul Roheim
Louisiana State University Medical Center
Henry Ginsberg
Columbia University
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Purpose
- TREATMENT
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 27, 1999
First Posted
October 28, 1999
Study Start
September 1, 1992
Primary Completion
May 1, 1995
Study Completion
May 1, 1995
Last Updated
February 22, 2024
Record last verified: 2014-08