NCT00000167|CompletedPhase 3DMC
Complications of Age-Related Macular Degeneration Prevention Trial
CAPT
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Sponsor study identifier
interventional
1,052
1 country
24
Study Start
May 1999
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
June 2006
Actual (reported)To determine whether application of low-intensity laser treatment of eyes with drusen in the macula can prevent later complications of age-related macular degeneration and thereby preserve visual function.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2006
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1999
Date type not reportedThis date has not been verified as actual or estimated.
September 23, 1999
Actual (reported)September 24, 1999
Actual (reported)June 2006
Actual (reported)Change in visual acuity (3-line loss)
5 years
Incidence of complications of AMD such as neovascularization, serous detachment of the pigment epithelium, and geographic atrophy
5 years
Changes in contrast threshold and critical print size for reading
5 years
Laser treatment
Initial: 60 barely visible burns, grid pattern. Re-treatment at 12 months: 30 barely visible burns, focal treatment.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Retinal Consultants of Arizona, Ltd.
Mesa, Arizona, 85201, United States
Retinal Consultants of Arizona, Ltd.
Peoria, Arizona, 85351, United States
West Coast Retina Medical Group, Inc.
San Francisco, California, 94107, United States
University of South Florida Eye Institute
Tampa, Florida, 33612-4766, United States
Emory Eye Center
Atlanta, Georgia, 30322, United States
Northwestern University
Chicago, Illinois, 60611, United States
Illinois Retina Associates, S.C.
Harvey, Illinois, 60426, United States
Brader HS, Ying GS, Martin ER, Maguire MG; Complications of Age-Related Macular Degeneration Prevention Trial-CAPT Research Group. New grading criteria allow for earlier detection of geographic atrophy in clinical trials. Invest Ophthalmol Vis Sci. 2011 Nov 29;52(12):9218-25. doi: 10.1167/iovs.11-7493.
Stuart L Fine, MD
Scheie Eye Institute, The University of Pennsylvania School of Medicine
1,052 participants (actual enrollment reported by the registry).
First Submitted
September 23, 1999
First Posted
September 24, 1999
Study Start
May 1999
Date type not reportedThis date has not been verified as actual or estimated.
A Study of rhuFab V2 (Ranibizumab) in Subjects With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration (AMD)
University of Iowa
Iowa City, Iowa, 55242-1091, United States
Ophthalmology & Visual Sciences at the University of Louisville, School of Medicine
Louisville, Kentucky, 40202-1594, United States
The Johns Hopkins University
Baltimore, Maryland, 21287-9223, United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, 02114, United States
Associate Retinal Consultants, P.C.
Royal Oak, Michigan, 48073, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Barnes Retina Institute
St Louis, Missouri, 63110, United States
Retina-Vitreous Center, P.A.
Edison, New Jersey, 08820, United States
Retina-Vitreous Center, P.A.
Lakewood, New Jersey, 08701, United States
Southeast Clinical Research Associates
Charlotte, North Carolina, 28204, United States
Retina Associates of Cleveland
Cleveland, Ohio, 44122, United States
The Ohio State University, Department of Ophthalmology
Columbus, Ohio, 43210, United States
Casey Eye Institute
Portland, Oregon, 97201-4197, United States
Retina Northwest, P.C.
Portland, Oregon, 97210, United States
Scheie Eye Institute
Philadelphia, Pennsylvania, 19104, United States
Texas Retina Associates
Dallas, Texas, 75231, United States
University of Wisconsin - Madison, Department of Ophthalmology and Visual Sciences
Madison, Wisconsin, 53705, United States
Study Completion
June 2006
Actual (reported)Last Updated
March 24, 2010
Record last verified: 2007-12
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Source: ClinicalTrials.gov.
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