The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study

NCT00000155 | Unknown

• 1 other identifier: NEI-57
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 14

Brief Summary

To describe the clinical course of keratoconus and to describe the relationships among its visual and physiological manifestations, including high- and low-contrast visual acuity, corneal curvature, slit lamp biomicroscopic findings, corneal scarring, and quality of life. To identify risk factors and protective factors that influence the severity and progression of keratoconus.

Conditions

Keratoconus

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Patients with keratoconus were eligible if they were at least 12 years old; had an irregular cornea as determined by keratometry, retinoscopy, or direct ophthalmoscopy in at least one eye; had Vogt's striae, Fleischer's ring, or corneal scarring characteristic of keratoconus in at least one eye; and planned to stay in the area for at least 3 years. They were ineligible if they had bilateral corneal transplants or bilateral nonkeratoconic eye disease (cataract, intraocular lenses, macular disease, or optic nerve disease other than glaucoma).

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Eye Institute (NEI): lead

Study Sites (14)

University of California, Berkeley, School of Optometry

Berkeley, California, 94720-2020, United States

Location

Southern California College of Optometry

Fullerton, California, 92831, United States

Location

Jules Stein Eye Institute, University of California at Los Angeles

Los Angeles, California, 90095-7003, United States

Location

Nova Southeastern University, Health Professions Division, College of Optometry

Fort Lauderdale, Florida, 33328, United States

Location

University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences

Chicago, Illinois, 60612, United States

Location

Indiana University, School of Optometry

Bloomington, Indiana, 47405-3680, United States

Location

University of Missouri-St. Louis, School of Optometry

St Louis, Missouri, 63121, United States

Location

SUNY State College of Optometry

New York, New York, 10036-8003, United States

Location

University Hospitals of Cleveland, Department of Ophthalmology

Cleveland, Ohio, 44106, United States

Location

The Ohio State University, College of Optometry

Columbus, Ohio, 43210-1240, United States

Location

Pennsylvania College of Optometry, The Eye Institute

Philadelphia, Pennsylvania, 19141, United States

Location

Northeastern Eye Institute

Scranton, Pennsylvania, 18503, United States

Location

University of Utah, John Moran Eye Center

Salt Lake City, Utah, 84132, United States

Location

Gundersen Lutheran

La Crosse, Wisconsin, 54601, United States

Location

Related Publications (4)

• Barr JT, Gordon MO, Zadnik K, Pellican K, Edrington TB. Photodocumentation of corneal scarring. Collaborative Longitudinal Evaluation of Keratoconus Study Group. J Refract Surg. 1996 May-Jun;12(4):492-500. doi: 10.3928/1081-597X-19960501-13.

  PMID: 8771545 BACKGROUND

• Edrington TB, Barr JT, Zadnik K, Davis LJ, Gundel RE, Libassi DP, McMahon TT, Gordon MO. Standardized rigid contact lens fitting protocol for keratoconus. Optom Vis Sci. 1996 Jun;73(6):369-75. doi: 10.1097/00006324-199606000-00003.

  PMID: 8807647 BACKGROUND

• Gundel RE, Libassi DP, Zadnik K, Barr JT, Davis L, McMahon TT, Edrington TB, Gordon MO. Feasibility of fitting contact lenses with apical clearance in keratoconus. Optom Vis Sci. 1996 Dec;73(12):729-32. doi: 10.1097/00006324-199612000-00002.

  PMID: 9002088 BACKGROUND

• Zadnik K, Barr JT, Gordon MO, Edrington TB. Biomicroscopic signs and disease severity in keratoconus. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group. Cornea. 1996 Mar;15(2):139-46. doi: 10.1097/00003226-199603000-00006.

  PMID: 8925661 BACKGROUND

MeSH Terms

Conditions

Keratoconus

Condition Hierarchy (Ancestors)

Corneal Diseases; Eye Diseases

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: September 23, 1999
• First Posted: September 24, 1999
• Study Start: June 1, 1995
• Last Updated: June 24, 2005

Record last verified: 2001-11

Locations

US (14)