Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

15.8%

6 terminated/withdrawn out of 38 trials

Success Rate

81.3%

-5.3% vs industry average

Late-Stage Pipeline

11%

4 trials in Phase 3/4

Results Transparency

8%

2 of 26 completed trials have results

Key Signals

3 recruiting2 with results

Enrollment Performance

Analytics

Phase 1
24(63.2%)
Phase 2
9(23.7%)
Phase 3
4(10.5%)
Early Phase 1
1(2.6%)
38Total
Phase 1(24)
Phase 2(9)
Phase 3(4)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (38)

Showing 20 of 38 trials
NCT07526506Phase 1Recruiting

Study of TRX-100 Tablets Evaluating the Safety, Pharmacokinetics, and Food Effect in Healthy Volunteers

Role: lead

NCT07503405Phase 2Not Yet Recruiting

Phase 2a Study of the Efficacy and Safety of TRX-100 in a Human Influenza A Challenge Model

Role: lead

NCT07371650Phase 2Active Not Recruiting

This is an Early-stage Clinical Trial to Determine a Safe and Effective Dose for Tivoxavir Marboxil in Patients With Mild to Moderate Influenza

Role: lead

NCT06402136Phase 1Completed

Evaluation Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of 83-0060 in Healthy Volunteers

Role: lead

NCT06757738Phase 1Completed

A Clinical Study Aiming to Assess Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of TRX-100 in Healthy Volunteers

Role: lead

NCT07157007Phase 2Recruiting

Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19

Role: lead

NCT04177498Early Phase 1Completed

Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC

Role: collaborator

NCT04263090Phase 1Completed

Rigosertib Plus Nivolumab for KRAS+ NSCLC Patients Who Progressed on First-Line Treatment

Role: collaborator

NCT05705505Phase 1Recruiting

Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies

Role: lead

NCT04739293Phase 1Unknown

Study of ON 123300 in Patients With Advanced Cancer

Role: lead

NCT02562443Phase 3Terminated

Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA

Role: lead

NCT02168725Phase 1Terminated

Dose-escalation, Safety and Pharmacokinetic Study of Briciclib in Advanced Solid Tumors

Role: lead

NCT01926587Phase 1Completed

Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine

Role: lead

NCT01904682Phase 2Completed

Oral Rigosertib in Low Risk MDS Patients Refractory to ESAs

Role: lead

NCT02730884Phase 2Terminated

Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia

Role: collaborator

NCT02075034Phase 1Withdrawn

Three Dosing Schedules of Oral Rigosertib in MDS Patients

Role: lead

NCT01241500Phase 3Completed

Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts

Role: lead

NCT01928537Phase 3Completed

Efficacy and Safety of IV Rigosertib in MDS Patients With Excess Blasts Progressing After Azacitidine or Decitabine

Role: lead

NCT00854646Phase 1Completed

Phase I Study of ON 01910.Na in Refractory Leukemia or Myelodysplastic Syndrome (MDS)

Role: lead

NCT00856791Phase 2Completed

Effect of 2-h Infusion of ON 01910.Na in Ovarian Cancer Patients

Role: lead