Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

16.1%

5 terminated/withdrawn out of 31 trials

Success Rate

83.3%

-3.2% vs industry average

Late-Stage Pipeline

10%

3 trials in Phase 3/4

Results Transparency

40%

10 of 25 completed trials have results

Key Signals

10 with results

Enrollment Performance

Analytics

Phase 2
19(70.4%)
Phase 1
5(18.5%)
Phase 3
3(11.1%)
27Total
Phase 2(19)
Phase 1(5)
Phase 3(3)

Activity Timeline

Global Presence

Loading network data...

Clinical Trials (31)

Showing 20 of 31 trials
NCT04300881Phase 2Terminated

Treatment of Post-Ocriplasmin Therapy Vitreolysis Induced Subretinal Fluid With Eplerenone (Mineralocorticoid Antagonists)

Role: collaborator

NCT02681809Phase 2Terminated

A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR

Role: lead

NCT03669393Phase 2Completed

A Study to Evaluate THR-317 Treatment for Macular Telangiectasia Type 1 (MacTel 1)

Role: lead

NCT03666923Phase 1Completed

A Study to Evaluate the Safety of THR-687 in Subjects With Diabetic Macular Edema (DME)

Role: lead

NCT03511898Phase 1Completed

A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME)

Role: lead

NCT03071068Phase 2Completed

A Study to Evaluate the Safety and Efficacy of THR-317 for the Treatment of Diabetic Macular Oedema (DME)

Role: lead

NCT02160340Completed

Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older

Role: collaborator

NCT01287988Completed

Follow-up Study to Assess Visual Function in Subset of Patients Who Have Previously Participated in the TG-MV-006 and TG-MV-007 Ocriplasmin Studies

Role: lead

NCT02079883Completed

Ocriplasmin Research to Better Inform Treatment (ORBIT)

Role: lead

NCT01429441Phase 3Completed

Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole

Role: lead

NCT02193945Completed

A Retrospective Chart Review of Patients Treated With Ocriplasmin for Symptomatic VMA

Role: lead

NCT00435539Phase 2Completed

A Study to Compare Multiple Doses Intravitreal Microplasmin for Treatment of Patients With Vitreomacular Traction (MIVI-IIt)

Role: lead

NCT00781859Phase 3Completed

Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial.

Role: lead

NCT00986362Phase 2Completed

Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy

Role: lead

NCT00913744Phase 2Completed

Safety and Efficacy Study of Intravitreal Ocriplasmin in Subjects With AMD With Focal Vitreomacular Adhesion

Role: lead

NCT01159665Phase 2Completed

The Purpose of This Study is to Evaluate the Pharmacokinetic Properties of Intravitreal Ocriplasmin Prior to Planned Primary Pars Plana Vitrectomy (PPV)

Role: lead

NCT00798317Phase 3Completed

Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial.

Role: lead

NCT00412958Phase 2Completed

A Study of the Safety and Efficacy of Microplasmin to Induce a Posterior Vitreous Detachment (MIVI III)

Role: lead

NCT00412451Phase 2Completed

A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME)

Role: lead

NCT00123305Phase 2Completed

Intravenous Administration of Microplasmin for Treatment of Acute Ischemic Stroke

Role: lead