Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 40/100

Failure Rate

9.8%

4 terminated/withdrawn out of 41 trials

Success Rate

84.6%

-1.9% vs industry average

Late-Stage Pipeline

17%

7 trials in Phase 3/4

Results Transparency

73%

16 of 22 completed trials have results

Key Signals

10 recruiting16 with results

Enrollment Performance

Analytics

Phase 2
24(61.5%)
Phase 1
8(20.5%)
Phase 3
6(15.4%)
Phase 4
1(2.6%)
39Total
Phase 2(24)
Phase 1(8)
Phase 3(6)
Phase 4(1)

Activity Timeline

Global Presence

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Clinical Trials (41)

Showing 20 of 41 trials
NCT05848258Phase 2Active Not Recruiting

An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis

Role: collaborator

NCT06782542Phase 2Recruiting

Olutasidenib, Venetoclax, and Azacitidine in IDH1 Mutated Newly Diagnosed Acute Myeloid Leukemia Patients Eligible for Intensive Induction Chemotherapy

Role: collaborator

NCT07032727Phase 2Recruiting

Olutasidenib Combined With Co-targeted Therapy in Relapsed or Refractory IDH1-mutated Myeloid Malignancies Harboring Activated Signaling Pathway Mutations

Role: collaborator

NCT06597734Phase 2Recruiting

A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm

Role: collaborator

NCT07486713Phase 4Recruiting

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

Role: lead

NCT07471841Phase 2Not Yet Recruiting

Olutasidenib in Relapsed IDH1 Mutated AML Patients Who Have Previously Received Venetoclax

Role: collaborator

NCT06566742Phase 2Recruiting

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

Role: collaborator

NCT07130695Phase 1Recruiting

Olutasidenib Single Plus Combo Therapy in IDH1mut AML After Induction and Consolidation

Role: collaborator

NCT06564207Phase 2Not Yet Recruiting

Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults

Role: collaborator

NCT06233110Phase 1Recruiting

Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

Role: collaborator

NCT04581954Phase 1Completed

Inflammatory Signal Inhibitors for COVID-19 (MATIS)

Role: collaborator

NCT05308264Phase 1Recruiting

Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

Role: lead

NCT06161974Phase 2Recruiting

Study of Olutasidenib and Temozolomide in HGG

Role: lead

NCT06639724Phase 1Recruiting

Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer

Role: collaborator

NCT03246074Phase 1Completed

Clinical Trial of Combined Fostamatinib and Paclitaxel in Ovarian Cancer

Role: collaborator

NCT04904276Terminated

Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy

Role: lead

NCT04543279Phase 2Terminated

Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia

Role: collaborator

NCT02077192Phase 3Completed

Open Label Study of R788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)

Role: lead

NCT04629703Phase 3Completed

Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects

Role: lead

NCT03764618Phase 3Completed

A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA

Role: lead