Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

14.3%

2 terminated/withdrawn out of 14 trials

Success Rate

85.7%

-0.8% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

17%

2 of 12 completed trials have results

Key Signals

2 with results

Enrollment Performance

Analytics

Phase 1
9(64.3%)
Phase 2
5(35.7%)
14Total
Phase 1(9)
Phase 2(5)

Activity Timeline

Global Presence

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Clinical Trials (14)

Showing 14 of 14 trials
NCT05146284Phase 2Withdrawn

Study to Assess PXL770 in Subjects With Adrenomyeloneuropathy (AMN) Form of X-linked Adrenoleukodystrophy (X-ALD or ALD)

Role: lead

NCT05200104Phase 2Withdrawn

Study to Assess PXL065 in Subjects With Adrenomyeloneuropathy (AMN) Form of X-linked Adrenoleukodystrophy (X-ALD or ALD)

Role: lead

NCT04321343Phase 2Completed

Study of PXL065 in Patients With Nonalcoholic Steatohepatitis (NASH)

Role: lead

NCT05441904Phase 1Completed

Study to Assess the Safety, Tolerability, and Pharmacokinetics of PXL770 in Healthy Subjects.

Role: lead

NCT03763877Phase 2Completed

A Study of the Efficacy and Safety of PXL770 Versus Placebo After 12 Weeks of Treatment in Patients With NAFLD

Role: lead

NCT03950882Phase 1Completed

A Study to Assess the Pharmacokinetics of PXL770 After 4 Weeks of Treatment in Subjects With NAFLD

Role: lead

NCT03802786Phase 1Completed

Pharmacokinetics of Imeglimin in Hepatic Impaired Subjects

Role: lead

NCT03886103Phase 1Completed

Pharmacokinetics and Metabolism of (14C)-Labelled PXL770

Role: lead

NCT03646331Phase 1Completed

Bioequivalence of Imeglimin Tablet Formulations

Role: lead

NCT03618316Phase 1Completed

Effect of Cimetidine on the PK of Imeglimin

Role: lead

NCT03395470Phase 1Completed

Safety, Tolerability and PK of PXL770 in Healthy Male Subjects

Role: lead

NCT02924337Phase 1Completed

Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects

Role: lead

NCT02373150Phase 1Completed

Safety, Tolerability and PK of Imeglimin in Japanese Volunteers

Role: lead

NCT01951235Phase 2Completed

A Study of the Efficacy and Safety of 4 Doses of Imeglimin After 24 Weeks of Treatment in Subjects With Type 2 Diabetes

Role: lead

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