Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

11.5%

6 terminated/withdrawn out of 52 trials

Success Rate

87.5%

+1.0% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

79%

33 of 42 completed trials have results

Key Signals

2 recruiting33 with results

Enrollment Performance

Analytics

N/A
42(100.0%)
42Total
N/A(42)

Activity Timeline

Global Presence

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Clinical Trials (52)

Showing 20 of 52 trials
NCT05385055Completed

Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking

Role: lead

NCT07108166Not ApplicableActive Not Recruiting

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

Role: lead

NCT07408180Not ApplicableCompleted

Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nicotine Tablet (NICOTINE TABLET) on Attention

Role: lead

NCT07459712Not ApplicableCompleted

Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes

Role: lead

NCT07443631Not ApplicableRecruiting

Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

Role: lead

NCT03837704Not ApplicableCompleted

Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue Smoking, or Quit Smoking.

Role: lead

NCT07135648Not ApplicableActive Not Recruiting

Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Current Smokers

Role: lead

NCT01959607Not ApplicableCompleted

Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)

Role: lead

NCT01780298Completed

Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study

Role: lead

NCT05859451Not ApplicableRecruiting

Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing

Role: collaborator

NCT05789420Not ApplicableCompleted

Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG

Role: lead

NCT05566678Not ApplicableWithdrawn

Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease

Role: lead

NCT05317195Not ApplicableCompleted

Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Cool Mint Mini Dry in Healthy Smokers

Role: lead

NCT05569005Not ApplicableTerminated

Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

Role: lead

NCT05599451Not ApplicableCompleted

Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS

Role: lead

NCT03020667Terminated

Japanese Post-Market Cohort Study

Role: lead

NCT06171490Not ApplicableCompleted

Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)

Role: lead

NCT05383508Not ApplicableCompleted

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Role: lead

NCT05487456Not ApplicableCompleted

Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence

Role: lead

NCT03527030Terminated

Cross-Sectional Survey on the Use of Tobacco Products - London (UK)

Role: lead