Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

44.4%

8 terminated/withdrawn out of 18 trials

Success Rate

27.3%

-59.2% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

133%

4 of 3 completed trials have results

Key Signals

3 recruiting4 with results6 terminated

Enrollment Performance

Analytics

Phase 1
13(72.2%)
Phase 2
4(22.2%)
Early Phase 1
1(5.6%)
18Total
Phase 1(13)
Phase 2(4)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (18)

Showing 18 of 18 trials
NCT07052305Phase 1Recruiting

NT-I7 (Efineptakin Alfa), a Long-acting Human IL-7, Post-Axicabtagene Ciloleucel or Post-Lisocabtagene Maraleucel in Subjects With Relapsed/Refractory Large B-cell Lymphoma

Role: collaborator

NCT07200089Phase 1Not Yet Recruiting

Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel)

Role: collaborator

NCT05600920Phase 1Recruiting

A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia

Role: collaborator

NCT04332653Phase 1Completed

NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

Role: lead

NCT05286060Phase 2Active Not Recruiting

Trial of the Combination of GX-188E Vaccination, GX-I7 and Pembrolizumab in Patients With Advanced, Resectable HPV Type 16 and/or 18 Positive Head and Neck Cancer

Role: collaborator

NCT05465954Phase 2Recruiting

Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma

Role: collaborator

NCT03687957Phase 1Active Not Recruiting

rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide

Role: collaborator

NCT04781309Early Phase 1Completed

NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy

Role: collaborator

NCT05075603Phase 1Completed

Relapsed/Refractory Large B-cell Lymphoma With NT-I7 Post-CD19 CAR T-cell Therapy

Role: lead

NCT03901573Phase 1Terminated

High-Risk Skin Cancers With Atezolizumab Plus NT-I7

Role: lead

NCT04588038Phase 1Terminated

NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery

Role: collaborator

NCT04594811Phase 1Terminated

NT-I7 in Combination With Nivolumab in Advanced Gastric, Gastro-Esophageal Junction or Esophageal Adenocarcinoma

Role: lead

NCT04984811Phase 2Active Not Recruiting

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

Role: lead

NCT04054752Phase 1Withdrawn

Vaccine Response With NT-I7

Role: collaborator

NCT02659800Phase 1Terminated

Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas

Role: collaborator

NCT04501796Phase 1Terminated

A Trial of NT-I7 in COVID-19 (SPESELPIS)

Role: lead

NCT02124902Phase 2Terminated

Neoadjuvant Treatment of Triple Negative Breast Cancer Patients With Docetaxel and Carboplatin to Assess Anti-tumor Activity

Role: collaborator

NCT04498325Phase 1Withdrawn

Evaluating the Effect of NT-I7, a Long Acting Interleukin-7, to Increase Lymphocyte Counts and Enhance Immune Clearance of SARS-CoV-2 (COVID-19)

Role: collaborator

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