Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 70/100

Failure Rate

31.3%

5 terminated/withdrawn out of 16 trials

Success Rate

66.7%

-19.8% vs industry average

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

110%

11 of 10 completed trials have results

Key Signals

11 with results

Enrollment Performance

Analytics

Phase 1
9(60.0%)
Phase 2
5(33.3%)
Phase 3
1(6.7%)
15Total
Phase 1(9)
Phase 2(5)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (16)

Showing 16 of 16 trials
NCT01147965Phase 1Completed

QUILT-3.038: Active Immunotherapy CEA Vaccine in Patients With Malignancies Expressing CEA

Role: lead

NCT00630552Phase 1Completed

QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer

Role: lead

NCT00807612Phase 1Terminated

QUILT-2.017: Phase 1b/2 Study of AMG 479 in Combination With Paclitaxel and Carboplatin for 1st Line Treatment of Advanced Squamous Non-Small Cell Lung Cancer

Role: lead

NCT00626106Phase 2Completed

QUILT-2.015: A Study of AMG 479 With Exemestane or Fulvestrant in Postmenopausal Women With Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer

Role: lead

NCT00791154Phase 1Terminated

QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer

Role: lead

NCT00819169Phase 1Terminated

QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors

Role: lead

NCT03127098Phase 1Terminated

QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer

Role: lead

NCT01231347Phase 3Completed

QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas

Role: lead

NCT01856920Phase 2Completed

QUILT-3.006 for Recurrent Medullary Thyroid Cancer

Role: lead

NCT02383498Phase 2Completed

QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma

Role: lead

NCT01061788Phase 1Completed

A Trial of AMG 479, Everolimus (RAD001) and Panitumumab in Patients With Advanced Cancer - QUILT-3.007

Role: collaborator

NCT03029481Unknown

Single Patient Expanded Access to Ganitumab for Metastatic Ewing Sarcoma

Role: collaborator

NCT01708161Phase 1Terminated

A Phase Ib/II Study of the Combination of BYL719 Plus AMG 479 in Adult Patients With Selected Solid Tumors

Role: collaborator

NCT00563680Phase 2Completed

QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors

Role: lead

NCT00974896Phase 1Completed

QUILT-2.016: Study of AMG 479 With Biologics or Chemotherapy for Subjects With Advanced Solid Tumors

Role: lead

NCT00813605Phase 2Completed

QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma

Role: lead

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