Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

43.3%

13 terminated/withdrawn out of 30 trials

Success Rate

48.0%

-38.5% vs industry average

Late-Stage Pipeline

33%

10 trials in Phase 3/4

Results Transparency

83%

10 of 12 completed trials have results

Key Signals

10 with results9 terminated4 withdrawn

Enrollment Performance

Analytics

Phase 3
9(60.0%)
Phase 2
4(26.7%)
Phase 1
1(6.7%)
Phase 4
1(6.7%)
15Total
Phase 3(9)
Phase 2(4)
Phase 1(1)
Phase 4(1)

Activity Timeline

Global Presence

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Clinical Trials (30)

Showing 20 of 30 trials
NCT02032823Phase 3Active Not Recruiting

Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer

Role: collaborator

NCT02000622Phase 3Completed

Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.

Role: collaborator

NCT01844986Phase 3Active Not Recruiting

Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.

Role: collaborator

NCT01874353Phase 3Active Not Recruiting

Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

Role: collaborator

NCT04404894Active Not Recruiting

Long-Term Prospective Registry in Prostate Cancer Patients From Diverse Urology Practice Settings Following Prolaris® Testing

Role: lead

NCT03737643Phase 3Active Not Recruiting

Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

Role: collaborator

NCT02184195Phase 3Completed

Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy

Role: collaborator

NCT01468623Phase 4Terminated

Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer Patients Treated With mFOLFOX6

Role: lead

NCT01905592Phase 3Terminated

A Phase III Trial of Niraparib Versus Physician's Choice in HER2 Negative, Germline BRCA Mutation-positive Breast Cancer Patients

Role: collaborator

NCT02282020Phase 3Completed

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Role: collaborator

NCT03290508Terminated

Long-term Study to Evaluate and Clinical Outcomes in Patients With Favorable Intermediate Risk Localized Prostate Cancer

Role: lead

NCT03152448Terminated

Prospective Prolaris Value and Efficacy

Role: lead

NCT04016935Terminated

EndoPredict® Extended Endocrine Trial (EXET)

Role: lead

NCT02889900Phase 2Completed

Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer

Role: collaborator

NCT02660034Phase 1Completed

The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors

Role: collaborator

NCT04015102Completed

A Registry for Hereditary Cancer Risk Assessment and Genetic Testing

Role: lead

NCT03511235Completed

Clinical Outcomes in Men With Prostate Cancer Who Selected Active Surveillance Using Prolaris® Testing

Role: lead

NCT02746367Completed

Bipolar Proteomic Assay Validation Study

Role: lead

NCT02034916Phase 2Terminated

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

Role: collaborator

NCT00960544Phase 2Withdrawn

Correlation of Genomic Variation in Enzymes Responsible for Metabolism of Capecitabine With Drug Metabolism

Role: collaborator