Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

21.7%

5 terminated/withdrawn out of 23 trials

Success Rate

76.2%

-10.3% vs industry average

Late-Stage Pipeline

9%

2 trials in Phase 3/4

Results Transparency

56%

9 of 16 completed trials have results

Key Signals

1 recruiting9 with results

Enrollment Performance

Analytics

Phase 1
16(69.6%)
Phase 2
5(21.7%)
Phase 3
2(8.7%)
23Total
Phase 1(16)
Phase 2(5)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (23)

Showing 20 of 23 trials
NCT03832361Phase 2Recruiting

Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer

Role: collaborator

NCT03835819Phase 2Active Not Recruiting

A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

Role: collaborator

NCT03552471Phase 1Completed

Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Role: collaborator

NCT04622774Phase 1Completed

First-in-Human Study of IMGC936 in Participants With Advanced Solid Tumors

Role: lead

NCT04296890Phase 3Completed

A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression

Role: lead

NCT02606305Phase 1Completed

Study of Mirvetuximab Soravtansine in Combination With Bevacizumab, Carboplatin, Pegylated Liposomal Doxorubicin, Pembrolizumab, or Bevacizumab + Carboplatin in Participants With Folate Receptor Alpha (FRα) Positive Advanced Epithelial Ovarian Cancer, Primary Peritoneal, or Fallopian Tube Cancer

Role: lead

NCT05320380Phase 1Withdrawn

A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat

Role: collaborator

NCT03102320Phase 1Completed

Phase 1b Multi-indication Study of Anetumab Ravtansine in Mesothelin Expressing Advanced Solid Tumors

Role: collaborator

NCT01609556Phase 1Completed

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Mirvetuximab Soravtansine in Adults With Ovarian Cancer and Other Folate Receptor 1 (FOLR1)-Positive Solid Tumors

Role: lead

NCT02631876Phase 3Completed

A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer

Role: lead

NCT02674763Phase 1Completed

Open-label Study of IMGN779 in Adult Patients With Relapsed/Refractory CD33-positive Acute Myeloid Leukemia

Role: lead

NCT03836157Phase 2Withdrawn

Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer

Role: collaborator

NCT02420873Phase 2Completed

An Open-label Phase II Study of Lorvotuzumab Mertansine

Role: collaborator

NCT01237678Phase 1Terminated

A Study of IMGN901 for Patients With Advanced Solid Tumors and Extensive Stage Small Cell Lung Cancer

Role: lead

NCT01534715Phase 1Completed

IMGN529 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Role: lead

NCT01963715Phase 1Terminated

A Phase 1 Study of IMGN289 in Adult Patients With EGFR-positive Solid Tumors

Role: lead

NCT00620607Phase 2Withdrawn

huC242-DM4 Treating Patients With Metastatic Gastric or Gastroesophageal Junction Carcinomas

Role: lead

NCT00346385Phase 1Completed

BB-10901 in Treating Patients With Relapsed or Refractory Solid Tumors

Role: lead

NCT00991562Phase 1Completed

IMGN901 in Combination With Lenalidomide and Dexamethasone

Role: lead

NCT00721669Phase 1Completed

A Phase I Dose-Escalation Study of IMGN388 in Patients With Solid Tumors

Role: lead