Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 90/100

Failure Rate

28.6%

6 terminated/withdrawn out of 21 trials

Success Rate

66.7%

-19.8% vs industry average

Late-Stage Pipeline

5%

1 trials in Phase 3/4

Results Transparency

42%

5 of 12 completed trials have results

Key Signals

3 recruiting5 with results

Enrollment Performance

Analytics

Phase 1
12(60.0%)
Phase 2
7(35.0%)
Phase 3
1(5.0%)
20Total
Phase 1(12)
Phase 2(7)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (21)

Showing 20 of 21 trials
NCT06285890Phase 1Recruiting

Phase I Study of HC-7366 for Acute Myeloid Leukemia

Role: collaborator

NCT07401875Phase 1Recruiting

A Phase 1b Study of HC-7366, an Agonist of ISR With Immunotherapy in Kidney Cancer (SHARK)

Role: collaborator

NCT03003468Phase 1Completed

Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017

Role: collaborator

NCT06234605Phase 1Recruiting

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

Role: lead

NCT00545545Phase 1Completed

Safety/Efficacy Study of Imprime PGG With Cetuximab in Patients With Recurrent/Progressive Colorectal Carcinoma

Role: lead

NCT02981303Phase 2Completed

Study of Imprime PGG and Pembrolizumab in Advanced Melanoma and Triple Negative Breast Cancer

Role: lead

NCT05484011Phase 1Terminated

A Maintenance Therapy Study of Odetiglucan With CDX-1140 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Role: lead

NCT02086175Phase 2Completed

A Phase 2 Clinical Trial of Rituxan and B-Glucan PGG in Relapsed Indolent Non-Hodgkin Lymphoma

Role: collaborator

NCT04834778Phase 1Completed

A Study of HC-5404-FU to Establish the Maximum Tolerated Dose (MTD)

Role: lead

NCT05121948Phase 1Terminated

A Study of HC-7366 to Establish the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D)

Role: lead

NCT05159778Phase 2Completed

Phase 2 Study of Imprime PGG and Pembrolizumab in Patients With HR+/HER2- Metastatic Breast Cancer (mBCA)

Role: lead

NCT04995094Phase 2Withdrawn

Study of Neoadjuvant Imprime PGG and Pembrolizumab for Stage III, Resectable Melanoma

Role: lead

NCT03246685Phase 2Terminated

Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro Monotherapy or Experiencing SD

Role: lead

NCT01309126Phase 3Terminated

Study of Imprime PGG® in Combination With Cetuximab in Subjects With Recurrent or Progressive KRAS Wild Type Colorectal Cancer

Role: lead

NCT00874107Phase 2Completed

Efficacy/Safety of Imprime PGG® Injection With Bevacizumab and Paclitaxel/Carboplatin in Patients With Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)

Role: lead

NCT00874848Phase 2Completed

Efficacy/Safety of Imprime PGG With Cetuximab & Paclitaxel/Carboplatin Therapy in Pts With Untreated Advanced Non-Small Cell Lung Cancer

Role: lead

NCT02132403Phase 1Terminated

(PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer

Role: collaborator

NCT00912327Completed

Efficacy and Safety Study of Imprime PGG With Cetuximab in Subjects With Stage IV KRAS-Mutated Colorectal Cancer

Role: lead

NCT00542464Phase 1Completed

Multiple-Dose, Dose-Escalation Safety, Pharmacodynamics, and Pharmacokinetics Study of Imprime PGG™ Injection

Role: lead

NCT00542529Phase 1Completed

Phase I/II, Randomized, Double-Blind, Study of the Progenitor Cell Mobilizing Effects of Imprime PGG™ Injection Administered at Varied Dosing Regimens With G-CSF Versus G-CSF Alone

Role: lead