Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

25.0%

5 terminated/withdrawn out of 20 trials

Success Rate

68.8%

-17.8% vs industry average

Late-Stage Pipeline

20%

4 trials in Phase 3/4

Results Transparency

91%

10 of 11 completed trials have results

Key Signals

3 recruiting10 with results

Enrollment Performance

Analytics

Phase 2
10(58.8%)
Phase 3
4(23.5%)
Phase 1
3(17.6%)
17Total
Phase 2(10)
Phase 3(4)
Phase 1(3)

Activity Timeline

Global Presence

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Clinical Trials (20)

Showing 20 of 20 trials
NCT05369975Phase 3Completed

Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts

Role: lead

NCT04935177Phase 3Completed

Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx

Role: lead

NCT05937750Phase 3Recruiting

A Long-term Follow-up Trial of Patients Previously Treated With Imlifidase Prior to Kidney Transplantation and a Non-comparative Transplanted Patient Group

Role: lead

NCT05753930Phase 2Recruiting

Imlifidase Prior to Kidney Transplant in Highly Sensitised Children

Role: lead

NCT05679401Phase 3Terminated

A Study With Imlifidase in Anti-GBM Disease

Role: lead

NCT06241950Phase 1Terminated

A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) Following Imlifidase Infusion in Participants With Duchenne Muscular Dystrophy (DMD) Determined to Have Pre-existing Antibodies to Recombinant Adeno-Associated Virus Serotype (rAAVrh74)

Role: collaborator

NCT05714514Active Not Recruiting

Survival and Dialysis Independency in Highly Sensitized Patients After Desensitization With Imlifidase and Tx of Kidneys

Role: lead

NCT05049850Phase 2Terminated

A Study to Investigate DSA Rebound in Patients Treated With Imlifidase Prior to Transplantation

Role: lead

NCT04711850Terminated

An Long-term Follow-up Trial of Kidney Tx Patients Treated With Imlifidase or PE After an AMR

Role: lead

NCT03943589Phase 2Completed

A Study of Imlifidase in Patients With Guillain-Barré Syndrome

Role: lead

NCT03611621Completed

A Follow up Study of Patients Treated With Imlifidase Prior to Kidney Transplantation

Role: lead

NCT06518005Phase 2Recruiting

Efficacy and Safety of GNT0003 Following Imlifidase Pre-treatment in Severe Crigler-Najjar Syndrome

Role: collaborator

NCT03897205Phase 2Completed

An Efficacy and Safety Study of Imlifidase in Treatment of Antibody-Mediated Rejection in Kidney Transplant Patients

Role: lead

NCT02426684Phase 1Completed

Ides in Highly Sensitized (HS) Patients Awaiting Kidney Transplantation

Role: collaborator

NCT03157037Phase 2Completed

Open-Label Phase II Study to Evaluate the Efficacy and Safety of IdeS in Anti-GBM Disease

Role: collaborator

NCT02790437Phase 2Completed

A Phase II Study to Evaluate the Efficacy of IdeS to Desensitize Transplant Patients With a Positive Crossmatch Test

Role: lead

NCT02854059Phase 2Terminated

IdeS in Asymptomatic Antibody-Mediated Thrombotic Thrombocytopenic Purpura (TTP) Patients

Role: lead

NCT02475551Phase 2Completed

Study to Evaluate the Safety, Tolerability, Efficacy and PK of IdeS in Kidney Transplantation

Role: lead

NCT02224820Phase 2Completed

Phase II Study, Evaluation of Safety and Efficacy of IdeS in Chronic Kidney Disease

Role: lead

NCT01802697Phase 1Completed

Safety Study on IdeS in Healthy Volounteers

Role: lead

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