Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

23.5%

4 terminated/withdrawn out of 17 trials

Success Rate

76.5%

-10.0% vs industry average

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

62%

8 of 13 completed trials have results

Key Signals

8 with results

Enrollment Performance

Analytics

Phase 1
11(64.7%)
Phase 2
5(29.4%)
Phase 3
1(5.9%)
17Total
Phase 1(11)
Phase 2(5)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (17)

Showing 17 of 17 trials
NCT04698915Phase 2Terminated

Phase 2b Study of GC4711 in Combination With SBRT for Nonmetastatic Pancreatic Cancer

Role: lead

NCT04476797Phase 1Terminated

Phase I/II Study of SBRT and GC4711 for Centrally Located or Large NSCLC

Role: lead

NCT03340974Phase 1Completed

Pilot Dose Escalation Trial of Stereotactic Body Radiation Therapy (SBRT) in Combination With GC4419 in Pancreatic Cancer

Role: lead

NCT03689712Phase 3Completed

ROMAN: Phase 3 Trial Investigating the Effects of GC4419 on Radiation Induced Oral Mucositis in Head/Neck Cancer Patients

Role: lead

NCT04225026Phase 2Terminated

Effects of Intravenous GC4419 on the Incidence and Severity of Esophagitis Due to Chemoradiotherapy for Lung Cancer

Role: lead

NCT04529850Phase 2Completed

Ph 2 Open Label Study of GC4419 to Reduce SOM Associated With Chemoradiotherapy for Head and Neck Cancer

Role: lead

NCT05412472Phase 1Completed

Study to Evaluate the Effects of Renal Impairment on the Pharmacokinetics, Safety and Tolerability of GC4419

Role: lead

NCT04555096Phase 2Terminated

A Trial of GC4419 in Patients With Critical Illness Due to COVID-19

Role: lead

NCT02508389Phase 2Completed

A Study of the Effects of GC4419 on Radiation Induced Oral Mucositis in Patients With Head/Neck Cancer

Role: lead

NCT03099824Phase 1Completed

A Phase 1 Study of the Safety and Pharmacokinetics of GC4711 (Oral Capsule) Compared to GC4419 (IV Infusion) and GC4711 (IV Infusion) in Healthy Volunteers

Role: lead

NCT03762031Phase 1Completed

A Study Designed to Evaluate the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 in Healthy Volunteers

Role: lead

NCT03792971Phase 1Completed

Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects

Role: lead

NCT03194139Phase 1Completed

A Study Designed to Compare the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 and GC4419 in Healthy Volunteers

Role: lead

NCT03164109Phase 1Completed

A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers

Role: lead

NCT03163173Phase 1Completed

A Study to Investigate the Absorption, Metabolism, Excretion, and Mass Balance of GC4419 in Healthy Adult Subjects

Role: lead

NCT03096756Phase 1Completed

A Study of the Safety, Tolerability and Pharmacokinetics of Orally-administered GC4702 in Healthy Volunteers

Role: lead

NCT01921426Phase 1Completed

A Phase 1 Dose Escalation Study of GC4419 in Combination With Chemoradiation for Squamous Cell Cancer of the Head & Neck

Role: lead

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