Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

15.4%

2 terminated/withdrawn out of 13 trials

Success Rate

75.0%

-11.5% vs industry average

Late-Stage Pipeline

54%

7 trials in Phase 3/4

Results Transparency

67%

4 of 6 completed trials have results

Key Signals

2 recruiting4 with results

Enrollment Performance

Analytics

Phase 3
7(53.8%)
N/A
2(15.4%)
Phase 1
2(15.4%)
Phase 2
2(15.4%)
13Total
Phase 3(7)
N/A(2)
Phase 1(2)
Phase 2(2)

Activity Timeline

Global Presence

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Clinical Trials (13)

Showing 13 of 13 trials
NCT04622046Phase 3Completed

A Phase 3 Study of ALXN2060 in Japanese Participants With Symptomatic ATTR-CM

Role: collaborator

NCT06563895Phase 3Recruiting

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

Role: lead

NCT06469372Not ApplicableCompleted

Cardiac Amyloidosis Discovery Trial

Role: collaborator

NCT04988386Phase 3Active Not Recruiting

Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Role: lead

NCT07116473Phase 3Not Yet Recruiting

To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Role: lead

NCT03536767Phase 2Active Not Recruiting

Open-Label Study of AG10 in Patients with Cardiomyopathy

Role: lead

NCT05577819Not ApplicableRecruiting

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Role: collaborator

NCT04882735Phase 3Withdrawn

Efficacy and Safety of Acoramidis (AG10) in Subjects with Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Role: lead

NCT03294707Phase 1Completed

Single and Multiple Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of AG10

Role: lead

NCT04769479Phase 1Completed

A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects

Role: lead

NCT04418024Phase 3Withdrawn

Efficacy and Safety of AG10 in Subjects with Transthyretin Amyloid Polyneurophathy

Role: lead

NCT03860935Phase 3Completed

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy

Role: lead

NCT03458130Phase 2Completed

Study of AG10 in Amyloid Cardiomyopathy

Role: lead

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