Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 100/100

Failure Rate

41.7%

5 terminated/withdrawn out of 12 trials

Success Rate

50.0%

-36.6% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

40%

2 of 5 completed trials have results

Key Signals

1 recruiting2 with results

Enrollment Performance

Analytics

Phase 2
6(50.0%)
Phase 1
6(50.0%)
12Total
Phase 2(6)
Phase 1(6)

Activity Timeline

Global Presence

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Clinical Trials (12)

Showing 12 of 12 trials
NCT05744739Phase 1Terminated

Tomivosertib in Relapsed or Refractory Acute Myeloid Leukemia (AML)

Role: collaborator

NCT05101564Phase 2Completed

Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast Cancer

Role: collaborator

NCT03690141Phase 2Terminated

An Open-label Study of the Effect of Tomivosertib (eFT508) in Patients With Advanced Castrate-resistant Prostate Cancer

Role: lead

NCT04092673Phase 1Recruiting

Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies

Role: lead

NCT04622007Phase 2Active Not Recruiting

Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)

Role: lead

NCT04632381Phase 1Completed

Intravenous Zotatifin in Adults With Mild or Moderate COVID-19

Role: lead

NCT03616834Phase 2Completed

Tomivosertib (eFT-508) in Combination With PD-1/PD-L1 Inhibitor Therapy

Role: lead

NCT04261218Phase 1Completed

Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of Tomivosertib Combined With Paclitaxel in Advanced Breast Cancer

Role: collaborator

NCT02937675Phase 1Terminated

A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies

Role: lead

NCT02605083Phase 1Terminated

A Dose Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Advanced Solid Tumors

Role: lead

NCT03318562Phase 2Terminated

A PD Study of Oral eFT508 in Subjects With Advanced TNBC and HCC

Role: lead

NCT03258398Phase 2Completed

A Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer

Role: lead

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