Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

27.8%

5 terminated/withdrawn out of 18 trials

Success Rate

64.3%

-22.2% vs industry average

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

56%

5 of 9 completed trials have results

Key Signals

2 recruiting5 with results

Enrollment Performance

Analytics

Phase 1
11(68.8%)
Phase 2
4(25.0%)
Phase 3
1(6.3%)
16Total
Phase 1(11)
Phase 2(4)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (18)

Showing 18 of 18 trials
NCT05001269Phase 2Completed

Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function

Role: lead

NCT05845398Phase 1Completed

Phase 1b Study of DCR-AUD in Healthy Volunteers

Role: lead

NCT04580420Phase 2Recruiting

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

Role: lead

NCT06504368Phase 1Recruiting

Safety, Tolerability, and Pharmacokinetics of DCR-PDL1 in Adults With Solid Tumors

Role: lead

NCT06098651Phase 1Completed

A Study of DCR-STAT3 in Adults With Solid Tumors

Role: lead

NCT05993416Unknown

Treatment of Primary Hyperoxaluria Type 1 With Nedosiran

Role: lead

NCT04042402Phase 3Active Not Recruiting

Long Term Extension Study in Patients With Primary Hyperoxaluria

Role: lead

NCT04764448Phase 2Terminated

A Study of Belcesiran in Patients With AATLD

Role: lead

NCT05021640Phase 1Completed

Study of DCR-AUD in Healthy Volunteers

Role: lead

NCT04542590Completed

Natural History of Patients With PH3 and a History of Stone Events

Role: lead

NCT04174118Phase 1Completed

Study of DCR-A1AT in Healthy Adult Volunteers

Role: lead

NCT04555486Phase 1Completed

Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients

Role: lead

NCT05146882Phase 2Withdrawn

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Role: lead

NCT03392896Phase 1Completed

Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria

Role: lead

NCT03772249Phase 1Completed

Study of Safety and Tolerability of DCR HBVS

Role: lead

NCT02110563Phase 1Terminated

Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma

Role: lead

NCT02314052Phase 1Terminated

Phase Ib/2, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Hepatocellular Carcinoma

Role: lead

NCT02795325Phase 1Terminated

A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)

Role: lead

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