Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 15/100

Failure Rate

8.7%

10 terminated/withdrawn out of 115 trials

Success Rate

89.7%

+3.2% vs industry average

Late-Stage Pipeline

32%

37 trials in Phase 3/4

Results Transparency

67%

58 of 87 completed trials have results

Key Signals

4 recruiting58 with results10 terminated

Enrollment Performance

Analytics

Phase 3
34(31.5%)
Phase 1
33(30.6%)
Phase 2
29(26.9%)
N/A
8(7.4%)
Phase 4
3(2.8%)
Early Phase 1
1(0.9%)
108Total
Phase 3(34)
Phase 1(33)
Phase 2(29)
N/A(8)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (115)

Showing 20 of 115 trials
NCT06989112Phase 3Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Role: collaborator

NCT02732275Phase 1Active Not Recruiting

DS-3201b in Participants With Lymphomas

Role: lead

NCT07303387Phase 2Recruiting

Efficacy and Safety of the Valemetostat in Patients With Selected Solid Tumors.

Role: collaborator

NCT04482309Phase 2Active Not Recruiting

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Role: collaborator

NCT05034887Phase 2Active Not Recruiting

Phase 2 Study of Trastuzumab Deruxtecan in the Neoadjuvant Treatment, or Trastuzumab Deruxtecan Plus Capecitabine Plus Durvalumab(MEDI4736) in the Preoperative and Postoperative Adjuvant Treatment for Patients With HER2 Positive Gastric and Gastroesophageal Junction Adenocarcinoma

Role: collaborator

NCT04639219Phase 2Active Not Recruiting

A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

Role: collaborator

NCT04458272Phase 2Active Not Recruiting

A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma

Role: lead

NCT04703322Phase 2Active Not Recruiting

A Study of Pexidartinib in Tenosynovial Giant Cell Tumor in Japan

Role: lead

NCT03523585Phase 3Completed

DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02]

Role: collaborator

NCT04619004Phase 2Active Not Recruiting

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

Role: collaborator

NCT02975700Not ApplicableCompleted

A Study of PLX3397 in Patients With Unresectable or Metastatic KIT-mutated Melanoma

Role: lead

NCT04556773Phase 1Active Not Recruiting

A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer

Role: collaborator

NCT04553770Phase 2Recruiting

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Role: collaborator

NCT06271837Phase 2Recruiting

A Study of T-DXd as Monotherapy or in Combination With Anti-cancer Agents in Patients With Selected HER2-expressing Tumors

Role: collaborator

NCT03401385Phase 1Active Not Recruiting

First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

Role: lead

NCT03529110Phase 3Active Not Recruiting

DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]

Role: collaborator

NCT03734029Phase 3Active Not Recruiting

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Role: collaborator

NCT04433234Phase 2Active Not Recruiting

Long-term, Extension Study of DS-5141b in Patients With Duchenne Muscular Dystrophy

Role: lead

NCT04488822Phase 3Active Not Recruiting

A Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With TGCT

Role: lead

NCT06074705Phase 1Terminated

A Study of DS-1471a In Subjects With Advanced Solid Tumors

Role: lead