Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

30.0%

3 terminated/withdrawn out of 10 trials

Success Rate

70.0%

-16.5% vs industry average

Late-Stage Pipeline

10%

1 trials in Phase 3/4

Results Transparency

71%

5 of 7 completed trials have results

Key Signals

5 with results

Enrollment Performance

Analytics

Phase 2
5(55.6%)
Phase 1
3(33.3%)
Phase 3
1(11.1%)
9Total
Phase 2(5)
Phase 1(3)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (10)

Showing 10 of 10 trials
NCT05039515Phase 2Terminated

A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).

Role: lead

NCT02279095Phase 2Completed

An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP)

Role: lead

NCT03312634Phase 3Completed

An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva.

Role: lead

NCT03442985Phase 2Terminated

An Efficacy and Safety Study of Palovarotene for the Treatment of MO

Role: lead

NCT04829773Phase 1Completed

Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects

Role: lead

NCT04829786Phase 1Completed

Study to Compare the Pharmacokinetics, Safety, and Tolerability Following Administration of Palovarotene in Healthy Japanese and Non-Asian Subjects

Role: lead

NCT04762355Phase 1Completed

Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects

Role: lead

NCT02190747Phase 2Completed

An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects

Role: lead

NCT02521792Phase 2Terminated

In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects

Role: lead

NCT02322255Completed

A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP)

Role: lead

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