Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 85/100

Failure Rate

18.2%

2 terminated/withdrawn out of 11 trials

Success Rate

60.0%

-26.5% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

0%

0 of 3 completed trials have results

Key Signals

2 recruiting

Enrollment Performance

Analytics

Phase 1
6(54.5%)
Phase 2
5(45.5%)
11Total
Phase 1(6)
Phase 2(5)

Activity Timeline

Global Presence

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Clinical Trials (11)

Showing 11 of 11 trials
NCT07085091Phase 1Recruiting

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

Role: lead

NCT07007559Phase 2Recruiting

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

Role: lead

NCT05027139Phase 1Completed

A Study of Zanidatamab (ZW25) With Evorpacept (ALX148) in Patients With Advanced HER2-expressing Cancer

Role: collaborator

NCT05002127Phase 2Active Not Recruiting

A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)

Role: lead

NCT04675333Phase 2Active Not Recruiting

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

Role: lead

NCT04675294Phase 2Active Not Recruiting

Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

Role: lead

NCT03013218Phase 1Completed

A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)

Role: lead

NCT05524545Phase 1Completed

A Study of Evorpacept (ALX148) With Enfortumab Vedotin for Subjects With Urothelial Carcinoma (ASPEN-07)

Role: lead

NCT04417517Phase 1Terminated

A Study of Evorpacept (ALX148) With Azacitidine for Higher Risk Myelodysplastic Syndrome (ASPEN-02)

Role: lead

NCT05167409Phase 2Active Not Recruiting

A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer

Role: collaborator

NCT04755244Phase 1Terminated

A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)

Role: lead

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