Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

6.7%

1 terminated/withdrawn out of 15 trials

Success Rate

88.9%

+2.4% vs industry average

Late-Stage Pipeline

7%

1 trials in Phase 3/4

Results Transparency

25%

2 of 8 completed trials have results

Key Signals

3 recruiting2 with results

Enrollment Performance

Analytics

Phase 2
2(33.3%)
N/A
1(16.7%)
Phase 4
1(16.7%)
Early Phase 1
1(16.7%)
Phase 1
1(16.7%)
6Total
Phase 2(2)
N/A(1)
Phase 4(1)
Early Phase 1(1)
+1 more

Activity Timeline

Global Presence

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Clinical Trials (15)

Showing 15 of 15 trials
NCT02014415Active Not Recruiting

Alpha-1 Antitrypsin Deficiency Adult Liver Study

Role: collaborator

NCT06505603Recruiting

PiMZ Longitudinal Cohort (PiMZ Logic)

Role: collaborator

NCT05297812Active Not Recruiting

Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease

Role: collaborator

NCT00884455Enrolling By Invitation

Alpha-1 Foundation DNA and Tissue Bank

Role: collaborator

NCT07135427Phase 4Recruiting

Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

Role: collaborator

NCT03823443Terminated

COPD Exacerbation Blood and Urine Biomarkers Study

Role: collaborator

NCT04157049Recruiting

Alpha-1 Research Registry

Role: lead

NCT00499941Completed

Alpha-1 Foundation Research Registry

Role: collaborator

NCT03008915Phase 2Completed

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Role: collaborator

NCT00377416Early Phase 1Completed

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency

Role: collaborator

NCT00532805Completed

The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency

Role: collaborator

NCT00430768Phase 1Completed

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency

Role: collaborator

NCT00067756Phase 2Completed

4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?

Role: collaborator

NCT01380626Not ApplicableCompleted

Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Role: collaborator

NCT01419158Completed

Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD)

Role: lead

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