Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 50/100

Failure Rate

13.3%

4 terminated/withdrawn out of 30 trials

Success Rate

63.6%

-22.9% vs industry average

Late-Stage Pipeline

23%

7 trials in Phase 3/4

Results Transparency

0%

0 of 7 completed trials have results

Key Signals

10 recruiting

Enrollment Performance

Analytics

Phase 1
15(50.0%)
Phase 3
7(23.3%)
Phase 2
7(23.3%)
N/A
1(3.3%)
30Total
Phase 1(15)
Phase 3(7)
Phase 2(7)
N/A(1)

Activity Timeline

Global Presence

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Clinical Trials (30)

Showing 20 of 30 trials
NCT05194995Phase 1Active Not Recruiting

JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutation

Role: lead

NCT06008288Phase 2Recruiting

A Phase II Study Evaluating JAB-21822 Monotherapy in Adult Patients With Pancreatic Cancer and Other Solid Tumors Harboring the KRAS p.G12C Mutation.

Role: lead

NCT05009329Phase 1Active Not Recruiting

A Study of JAB-21822 in Adult Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation in China

Role: lead

NCT06955988Phase 1Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AST2303 Tablets (ABK3376 Tablets) in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer

Role: lead

NCT06956001Phase 3Recruiting

Firmonertinib Versus Platinum Based Chemotherapy as First-line Treatment for NSCLC With EGFR PACC or EGFR l861q Mutation

Role: lead

NCT06970639Phase 3Recruiting

A Study Evaluating Furmonertinib Plus Platinum-based Doublet Chemotherapy Versus Osimertinib in Patients With Epidermal Growth Factor Receptor (EGFR) Sensitizing Mutation-Positive Non-squamous Non-Small Cell Lung Cancer (NSCLC) and Brain Metastases

Role: lead

NCT04858958Phase 1Active Not Recruiting

Study of FURMONERTINIB in Patients With NSCLC Having Exon 20 Insertion Mutation

Role: lead

NCT05466149Phase 2Active Not Recruiting

Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion

Role: lead

NCT05607550Phase 3Active Not Recruiting

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

Role: collaborator

NCT07010419Phase 3Recruiting

A Study to Assess the Efficacy and Safety of Firmonertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB - IIIB NSCLC With Uncommon Epidermal Growth Factor Receptor (EGFR) Mutations, Following Complete Surgical Resection With or Without Adjuvant Chemotherapy(FIRMOST)

Role: lead

NCT04121286Phase 1Completed

A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China

Role: lead

NCT03787992Phase 3Active Not Recruiting

Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLAG)

Role: lead

NCT04720976Phase 1Completed

JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors

Role: lead

NCT05875493Phase 1Completed

A Food Effect Study of JAB-21822 in Healthy Subjects

Role: lead

NCT04853342Phase 3Recruiting

To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy

Role: lead

NCT05276726Phase 1Recruiting

A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

Role: lead

NCT05920941Phase 1Completed

Mass Balance Study of [14C]JAB-21822

Role: lead

NCT05288205Phase 1Recruiting

Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation

Role: lead

NCT06416410Phase 3Recruiting

JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

Role: lead

NCT06162169Phase 1Completed

A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects

Role: lead