Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

19.5%

8 terminated/withdrawn out of 41 trials

Success Rate

70.4%

-16.1% vs industry average

Late-Stage Pipeline

5%

2 trials in Phase 3/4

Results Transparency

53%

10 of 19 completed trials have results

Key Signals

1 recruiting10 with results7 terminated

Enrollment Performance

Analytics

Phase 1
29(76.3%)
Phase 2
7(18.4%)
Phase 3
2(5.3%)
38Total
Phase 1(29)
Phase 2(7)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (41)

Showing 20 of 41 trials
NCT01492036Recruiting

Long-Term Follow-Up of Recipient of Gene Transfer Research

Role: collaborator

NCT05194735Phase 1Terminated

Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors

Role: lead

NCT01397708Phase 1Completed

Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma

Role: lead

NCT03679754Phase 1Completed

Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102

Role: lead

NCT02423902Phase 1Terminated

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Breast Cancer

Role: lead

NCT01703754Phase 2Terminated

Adenoviral Vector Monotherapy or Combination With Chemotherapy in Subjects With Recurrent/Metastatic Breast Cancer.

Role: lead

NCT03636477Phase 1Completed

A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102

Role: lead

NCT03330197Phase 1Terminated

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

Role: lead

NCT05124743Terminated

HLA Typing & Tumor Neoantigen Identification for Phase I/II Study of Autologous TCR-T Cells in Subjects With Solid Tumors

Role: lead

NCT05292859Completed

Long-Term Follow-up Study of Subjects Treated With Autologous T Cells Using the Sleeping Beauty System to Express TCRs

Role: lead

NCT04006119Phase 2Terminated

Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma

Role: lead

NCT02026271Phase 1Completed

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

Role: lead

NCT00968760Phase 1Completed

CD19-specific T Cell Infusion in Patients With B-Lineage Lymphoid Malignancies

Role: collaborator

NCT01808534Phase 2Terminated

Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors

Role: collaborator

NCT00439686Phase 1Completed

Study of ZIO-201 in Advanced Sarcoma

Role: lead

NCT00718484Phase 2Unknown

A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-tissue Sarcoma

Role: lead

NCT00423306Phase 2Unknown

A Phase-II Trial of ZIO 101 in Advanced Hepatocellular Carcinoma

Role: lead

NCT00423644Phase 2Unknown

A Phase II Trial of ZIO-101 in Advanced Multiple Myeloma: Protocol SGL2001b

Role: lead

NCT00815607Phase 1Completed

Trial of an Intratumoral Injections of INXN-3001 in Subjects With Stage III or IV Melanoma

Role: lead

NCT01168791Phase 3Completed

Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue Sarcoma

Role: lead